SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4obu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 9 LEU E 167
ILE E 164
ASN E 163
VAL E 156
GLY E 158
 None
None
PLP  E 501 ( 4.4A)
None
PLP  E 501 ( 4.3A)
 1.27A 1e7aA-4obuE:
undetectable		 1e7aA-4obuE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 ARG E 210
ALA E 185
ASP E 232
GLY E 183
 None
 1.07A 1e7bA-4obuE:
undetectable		 1e7bA-4obuE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 THR E 248
ILE E 273
ILE E 300
ILE E 209
ALA E 196
 None
 1.15A 1jtxA-4obuE:
undetectable		 1jtxA-4obuE:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 ALA E 443
LEU E 394
GLY E 440
TYR E 441
LEU E 476
 None
 1.14A 1qabF-4obuE:
undetectable		 1qabF-4obuE:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 THR E 485
TYR E 484
TYR E 415
LEU E 428
 None
 1.10A 1qzrA-4obuE:
undetectable		 1qzrA-4obuE:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 THR E 485
TYR E 484
TYR E 415
LEU E 428
 None
 1.10A 1qzrB-4obuE:
undetectable		 1qzrB-4obuE:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 GLY E 275
SER E 301
ILE E 243
HIS E 272
 None
 0.89A 1yajF-4obuE:
undetectable		 1yajF-4obuE:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 4 GLY E 275
SER E 301
ILE E 243
HIS E 272
 None
 0.89A 1yajJ-4obuE:
undetectable		 1yajJ-4obuE:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 ILE E 164
ASN E 163
VAL E 156
GLY E 158
SER E 299
 None
PLP  E 501 ( 4.4A)
None
PLP  E 501 ( 4.3A)
None
 1.32A 2bxeA-4obuE:
undetectable		 2bxeA-4obuE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 LEU E 167
ILE E 164
ASN E 163
VAL E 156
GLY E 158
 None
None
PLP  E 501 ( 4.4A)
None
PLP  E 501 ( 4.3A)
 1.32A 2bxeA-4obuE:
undetectable		 2bxeA-4obuE:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.38A 2dysA-4obuE:
undetectable
2dysC-4obuE:
undetectable		 2dysA-4obuE:
22.90
2dysC-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.38A 2eikA-4obuE:
undetectable
2eikC-4obuE:
undetectable		 2eikA-4obuE:
22.90
2eikC-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.39A 2eilA-4obuE:
undetectable
2eilC-4obuE:
undetectable		 2eilA-4obuE:
22.90
2eilC-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.37A 2eimA-4obuE:
undetectable
2eimC-4obuE:
undetectable		 2eimA-4obuE:
22.90
2eimC-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.46A 2eimN-4obuE:
undetectable
2eimP-4obuE:
undetectable		 2eimN-4obuE:
22.90
2eimP-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 8 ILE E 254
TRP E 307
PHE E  98
GLY E 275
 None
None
PLP  E 501 (-4.7A)
None
 0.92A 2qwxA-4obuE:
undetectable
2qwxB-4obuE:
undetectable		 2qwxA-4obuE:
20.21
2qwxB-4obuE:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 10 ILE E 300
MET E 408
LEU E 282
VAL E 281
LEU E 291
 None
 1.49A 2w98A-4obuE:
undetectable		 2w98A-4obuE:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 ILE E 273
MET E 408
LEU E 282
LEU E 291
 None
 1.18A 2zb7A-4obuE:
undetectable		 2zb7A-4obuE:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.35A 3abkA-4obuE:
undetectable
3abkC-4obuE:
undetectable		 3abkA-4obuE:
22.90
3abkC-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.39A 3abkN-4obuE:
undetectable
3abkP-4obuE:
undetectable		 3abkN-4obuE:
22.90
3abkP-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.38A 3ag1A-4obuE:
undetectable
3ag1C-4obuE:
undetectable		 3ag1A-4obuE:
22.90
3ag1C-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.34A 3ag2A-4obuE:
undetectable
3ag2C-4obuE:
undetectable		 3ag2A-4obuE:
22.90
3ag2C-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.36A 3ag3A-4obuE:
undetectable
3ag3C-4obuE:
undetectable		 3ag3A-4obuE:
22.90
3ag3C-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.37A 3ag3N-4obuE:
undetectable
3ag3P-4obuE:
undetectable		 3ag3N-4obuE:
22.90
3ag3P-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 HIS E  92
ASP E 474
THR E 472
HIS E  44
 None
 1.36A 3ag4A-4obuE:
undetectable
3ag4C-4obuE:
undetectable		 3ag4A-4obuE:
22.90
3ag4C-4obuE:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		3 / 3 GLY E 252
GLY E 278
GLY E 247
 None
 0.38A 3bogD-4obuE:
undetectable		 3bogD-4obuE:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 MET E 316
ALA E 279
LEU E 283
LEU E 282
LEU E 308
 None
 1.20A 3erdA-4obuE:
undetectable		 3erdA-4obuE:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 10 MET E 316
ALA E 279
LEU E 283
LEU E 282
LEU E 308
 None
 1.24A 3erdB-4obuE:
undetectable		 3erdB-4obuE:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 GLY E 244
THR E 248
ASP E 298
ALA E 297
ASP E 255
 None
 1.32A 3id5B-4obuE:
undetectable		 3id5B-4obuE:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 GLY E 244
THR E 248
ASP E 298
ALA E 297
ASP E 255
 None
 1.32A 3id5F-4obuE:
undetectable		 3id5F-4obuE:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 TRP E 307
PHE E 384
GLY E 377
PHE E 309
LEU E 283
 None
 1.24A 3iv6B-4obuE:
2.1		 3iv6B-4obuE:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 9 ALA E 169
ASP E 172
GLY E 352
LEU E 318
VAL E 319
 None
 1.06A 3u7sB-4obuE:
undetectable		 3u7sB-4obuE:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 GLN E 190
GLY E 247
PHE E 218
ALA E 279
ALA E 246
 None
 1.17A 4pclA-4obuE:
4.0		 4pclA-4obuE:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 GLN E 190
GLY E 247
PHE E 218
ALA E 279
ALA E 246
 None
 1.17A 4pclB-4obuE:
3.5		 4pclB-4obuE:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 8 ILE E 254
TRP E 307
PHE E  98
GLY E 275
 None
None
PLP  E 501 (-4.7A)
None
 0.93A 4qogA-4obuE:
2.3
4qogB-4obuE:
undetectable		 4qogA-4obuE:
20.21
4qogB-4obuE:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 8 TRP E 307
PHE E  98
GLY E 275
ILE E 273
 None
PLP  E 501 (-4.7A)
None
None
 0.97A 4qoiA-4obuE:
undetectable
4qoiB-4obuE:
undetectable		 4qoiA-4obuE:
20.21
4qoiB-4obuE:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 4 GLY E 159
VAL E 317
PHE E 271
ILE E 273
 PLP  E 501 (-3.5A)
None
None
None
 1.13A 4xv2B-4obuE:
1.8		 4xv2B-4obuE:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 MET E 316
ALA E 279
LEU E 283
LEU E 282
LEU E 308
 None
 1.16A 4zn7B-4obuE:
undetectable		 4zn7B-4obuE:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		3 / 3 THR E 251
SER E 253
ASP E 274
 None
None
PLP  E 501 (-2.4A)
 0.67A 5kvaA-4obuE:
undetectable		 5kvaA-4obuE:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		3 / 3 THR E 251
SER E 253
ASP E 274
 None
None
PLP  E 501 (-2.4A)
 0.67A 5kvaB-4obuE:
undetectable		 5kvaB-4obuE:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 ILE E 212
THR E 214
LEU E 263
VAL E 242
GLU E 259
 None
 1.05A 5l8oB-4obuE:
undetectable		 5l8oB-4obuE:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 8 GLY E 153
LEU E 318
SER E 301
ALA E 162
 None
 0.78A 5xu8A-4obuE:
undetectable		 5xu8A-4obuE:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4obu PYRIDOXAL-DEPENDENT
DECARBOXYLASE DOMAIN
PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 HIS E 120
ALA E 127
SER E 124
GLY E 123
 None
 1.27A 5yodB-4obuE:
undetectable		 5yodB-4obuE:
15.92