SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4obw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
5 / 10 ASP A 117
GLY A 128
ILE A 193
LEU A 101
ALA A 103
None
1.17A 1x7pA-4obwA:
2.8
1x7pB-4obwA:
2.8
1x7pA-4obwA:
21.50
1x7pB-4obwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
5 / 12 ALA A 161
LEU A 130
GLY A 128
PHE A 127
MET A 144
None
1.15A 3k2hA-4obwA:
undetectable
3k2hA-4obwA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
5 / 12 ALA A 161
LEU A 130
GLY A 128
PHE A 127
MET A 144
None
1.14A 3k2hB-4obwA:
undetectable
3k2hB-4obwA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
5 / 11 ASP A 117
GLY A 121
ILE A 125
ASP A 148
ASN A 179
None
None
None
SAM  A 602 (-2.9A)
SAM  A 602 (-3.7A)
0.78A 4dcmA-4obwA:
18.3
4dcmA-4obwA:
21.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
12 / 12 TYR A  78
ASN A  82
LYS A  94
ALA A 119
GLY A 120
SER A 122
ILE A 149
ASN A 150
MET A 153
GLY A 180
ASN A 202
PHE A 203
SAM  A 602 (-3.9A)
SAM  A 602 ( 4.2A)
SAM  A 602 (-3.3A)
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
SAM  A 602 (-3.1A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.04A 4obwA-4obwA:
43.8
4obwA-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
7 / 12 TYR A  78
GLY A 121
SER A 122
ILE A 149
ASN A 150
GLY A 180
ASN A 202
SAM  A 602 (-3.9A)
None
SAM  A 602 (-3.1A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
1.10A 4obwA-4obwA:
43.8
4obwA-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
9 / 12 ALA A 119
GLY A 120
GLY A 121
ASP A 124
ILE A 149
ASN A 150
GLY A 180
ASN A 202
PHE A 203
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
None
None
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.75A 4obwB-4obwA:
39.2
4obwB-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
9 / 12 ALA A 119
GLY A 120
GLY A 121
ILE A 149
ASN A 150
MET A 153
GLY A 180
ASN A 202
PHE A 203
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
None
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.85A 4obwB-4obwA:
39.2
4obwB-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
8 / 12 TYR A  78
ASN A  82
ALA A 119
GLY A 120
ASP A 124
ILE A 149
ASN A 150
ASN A 202
SAM  A 602 (-3.9A)
SAM  A 602 ( 4.2A)
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
None
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 ( 4.9A)
1.09A 4obwB-4obwA:
39.2
4obwB-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
10 / 12 TYR A  78
ASN A  82
ALA A 119
GLY A 120
ASP A 124
ILE A 149
ASN A 150
GLY A 180
ASN A 202
PHE A 203
SAM  A 602 (-3.9A)
SAM  A 602 ( 4.2A)
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
None
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.59A 4obwB-4obwA:
39.2
4obwB-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
10 / 12 TYR A  78
ASN A  82
ALA A 119
GLY A 120
ILE A 149
ASN A 150
MET A 153
GLY A 180
ASN A 202
PHE A 203
SAM  A 602 (-3.9A)
SAM  A 602 ( 4.2A)
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.69A 4obwB-4obwA:
39.2
4obwB-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
7 / 12 TYR A  78
ASN A  82
GLY A 121
ASP A 124
ILE A 149
GLY A 180
ASN A 202
SAM  A 602 (-3.9A)
SAM  A 602 ( 4.2A)
None
None
SAM  A 602 (-3.8A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
1.06A 4obwB-4obwA:
39.2
4obwB-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_B_SAMB601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
4 / 4 LYS A  94
ASP A 148
ASN A 179
SER A 197
SAM  A 602 (-3.3A)
SAM  A 602 (-2.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-2.9A)
0.27A 4obwB-4obwA:
39.2
4obwB-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
12 / 12 TYR A  78
ASN A  82
GLY A 120
SER A 122
ASP A 124
ILE A 149
ASN A 150
GLY A 180
SER A 197
ARG A 201
ASN A 202
PHE A 203
SAM  A 602 (-3.9A)
SAM  A 602 ( 4.2A)
SAM  A 602 (-3.4A)
SAM  A 602 (-3.1A)
None
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.5A)
SAM  A 602 (-2.9A)
None
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.40A 4obwC-4obwA:
40.4
4obwC-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
8 / 12 TYR A  78
ASN A  82
GLY A 121
SER A 122
ASP A 124
ILE A 149
GLY A 180
ASN A 202
SAM  A 602 (-3.9A)
SAM  A 602 ( 4.2A)
None
SAM  A 602 (-3.1A)
None
SAM  A 602 (-3.8A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
1.19A 4obwC-4obwA:
40.4
4obwC-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_C_SAMC601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
5 / 5 LYS A  94
ALA A 119
ASP A 148
MET A 153
ASN A 179
SAM  A 602 (-3.3A)
SAM  A 602 (-3.2A)
SAM  A 602 (-2.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.7A)
0.34A 4obwC-4obwA:
40.4
4obwC-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
6 / 12 TYR A  78
GLY A 121
ILE A 149
ASN A 179
GLY A 180
ASN A 202
SAM  A 602 (-3.9A)
None
SAM  A 602 (-3.8A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.5A)
SAM  A 602 ( 4.9A)
0.97A 4obwD-4obwA:
41.0
4obwD-4obwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
12 / 12 TYR A  78
LYS A  94
ALA A 119
GLY A 120
ILE A 149
ASN A 150
MET A 153
ASN A 179
GLY A 180
ARG A 201
ASN A 202
PHE A 203
SAM  A 602 (-3.9A)
SAM  A 602 (-3.3A)
SAM  A 602 (-3.2A)
SAM  A 602 (-3.4A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.7A)
SAM  A 602 (-3.5A)
None
SAM  A 602 ( 4.9A)
SAM  A 602 (-3.9A)
0.26A 4obwD-4obwA:
41.0
4obwD-4obwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
5 / 12 GLY A 121
ILE A 149
MET A 153
ILE A 125
SER A 197
None
SAM  A 602 (-3.8A)
SAM  A 602 (-3.7A)
None
SAM  A 602 (-2.9A)
0.74A 4qtuD-4obwA:
18.5
4qtuD-4obwA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
5 / 12 GLY A 121
ASP A 148
ILE A 149
ASN A 150
ASP A 117
None
SAM  A 602 (-2.9A)
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
None
1.14A 4rtsA-4obwA:
11.3
4rtsA-4obwA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
5 / 12 GLY A 121
ILE A 125
ILE A 149
ASN A 150
ASN A 179
None
None
SAM  A 602 (-3.8A)
SAM  A 602 (-4.9A)
SAM  A 602 (-3.7A)
0.99A 5fa8A-4obwA:
14.4
5fa8A-4obwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
4 / 4 PHE A 115
ASP A 145
LEU A 113
LYS A 191
None
1.30A 6awvA-4obwA:
undetectable
6awvA-4obwA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)
4obw 2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae)
4 / 7 VAL A 173
LEU A 154
GLY A 123
GLY A 165
None
0.77A 6eu9D-4obwA:
undetectable
6eu9D-4obwA:
20.37