SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 138
ALA A 141
ALA A 142
LEU A 434
HIS A 366
 None
 1.07A 1fbyB-4obyA:
undetectable		 1fbyB-4obyA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		4 / 5 GLU A 396
LEU A 394
LEU A 393
LEU A 398
 None
 1.11A 1np1A-4obyA:
undetectable		 1np1A-4obyA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		4 / 6 TYR A 323
TYR A 261
HIS A 158
VAL A 116
 None
None
ARG  A 601 (-3.7A)
None
 1.11A 1q13A-4obyA:
undetectable		 1q13A-4obyA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		3 / 3 ARG A 324
VAL A 352
TRP A 349
 ARG  A 601 ( 4.6A)
None
None
 1.25A 1qwcA-4obyA:
1.8		 1qwcA-4obyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		5 / 10 ALA A  59
LEU A  66
LYS A  10
ILE A  85
LEU A   7
 None
 1.46A 1tdrB-4obyA:
undetectable		 1tdrB-4obyA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		3 / 3 ARG A 324
VAL A 352
TRP A 349
 ARG  A 601 ( 4.6A)
None
None
 1.27A 1vagA-4obyA:
undetectable		 1vagA-4obyA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		5 / 12 ARG A 245
THR A 249
VAL A 248
LEU A 133
ILE A 137
 None
 1.36A 2fj1A-4obyA:
undetectable		 2fj1A-4obyA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		5 / 12 GLY A 427
GLY A 425
LEU A 450
ASN A 455
GLU A 572
 None
 1.18A 2zw9B-4obyA:
undetectable		 2zw9B-4obyA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		4 / 8 ASN A 239
THR A 242
LEU A 246
HIS A 132
 None
None
None
ARG  A 601 (-4.0A)
 0.86A 3kp2A-4obyA:
undetectable
3kp2B-4obyA:
undetectable		 3kp2A-4obyA:
14.36
3kp2B-4obyA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		4 / 8 TYR A 442
PHE A 380
ARG A 383
ASP A 392
 None
 1.06A 3mjrD-4obyA:
undetectable		 3mjrD-4obyA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		5 / 10 SER A 135
ARG A 324
ASP A 317
TYR A 335
LEU A 345
 None
ARG  A 601 ( 4.6A)
ARG  A 601 (-2.6A)
ARG  A 601 (-4.8A)
None
 1.38A 3n2oC-4obyA:
4.7
3n2oD-4obyA:
5.3		 3n2oC-4obyA:
23.06
3n2oD-4obyA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		4 / 8 ASP A  88
ILE A  71
LYS A  10
ILE A  85
 None
 0.92A 4ndnB-4obyA:
undetectable		 4ndnB-4obyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		5 / 12 ALA A 397
LEU A 393
THR A 136
LYS A 430
ALA A 432
 None
 1.23A 4x1kA-4obyA:
undetectable
4x1kB-4obyA:
undetectable		 4x1kA-4obyA:
21.55
4x1kB-4obyA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		5 / 11 ASP A 271
ALA A 350
TYR A 357
GLY A 276
VAL A 287
 None
 1.09A 4xnxA-4obyA:
3.6		 4xnxA-4obyA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		3 / 3 ARG A 324
VAL A 352
TRP A 349
 ARG  A 601 ( 4.6A)
None
None
 1.23A 5fvoA-4obyA:
1.9		 5fvoA-4obyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		4 / 7 ASP A 567
THR A 568
LEU A 566
VAL A 574
 None
 1.10A 5ov9A-4obyA:
2.9		 5ov9A-4obyA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		3 / 3 GLU A 147
HIS A 151
VAL A 153
 None
 0.89A 5trqB-4obyA:
undetectable		 5trqB-4obyA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		4 / 6 MET A 449
VAL A 424
LEU A 450
GLN A 461
 None
 1.47A 5xdhA-4obyA:
undetectable
5xdhC-4obyA:
undetectable		 5xdhA-4obyA:
8.52
5xdhC-4obyA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4oby ARGININE--TRNA
LIGASE
(Escherichia
coli) 		5 / 10 VAL A  11
LEU A   7
GLY A  37
GLN A  40
VAL A  75
 None
 1.32A 6czmE-4obyA:
undetectable
6czmF-4obyA:
3.1		 6czmE-4obyA:
22.88
6czmF-4obyA:
22.88