SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		4 / 8 TYR A  82
PHE A  80
ARG A  87
THR A 127
 None
 0.98A 1ea1A-4oc8A:
undetectable		 1ea1A-4oc8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		4 / 7 PHE A 125
LEU A  57
VAL A  40
GLY A  39
 None
None
None
PO4  A 403 ( 4.4A)
 0.95A 1t88A-4oc8A:
undetectable		 1t88A-4oc8A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		5 / 12 LEU A 263
ALA A 304
LEU A 321
ARG A 324
LEU A 356
 None
 1.29A 1ya3B-4oc8A:
undetectable		 1ya3B-4oc8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		4 / 8 PHE A 125
LEU A  57
VAL A  40
GLY A  39
 None
None
None
PO4  A 403 ( 4.4A)
 0.90A 2a1oA-4oc8A:
undetectable		 2a1oA-4oc8A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		4 / 7 LEU A  37
PRO A 198
VAL A 185
TRP A 184
 None
 1.21A 2hrcA-4oc8A:
undetectable		 2hrcA-4oc8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		4 / 8 ALA A 170
PHE A  80
THR A 173
ASP A  71
 None
 1.17A 2kotB-4oc8A:
undetectable		 2kotB-4oc8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		5 / 12 LEU A 263
ALA A 304
LEU A 321
ARG A 324
LEU A 356
 None
 1.40A 2oaxC-4oc8A:
undetectable		 2oaxC-4oc8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		5 / 12 LEU A 263
ALA A 304
LEU A 321
ARG A 324
LEU A 356
 None
 1.37A 2oaxD-4oc8A:
undetectable		 2oaxD-4oc8A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		5 / 12 LEU A 263
ALA A 304
LEU A 321
ARG A 324
LEU A 356
 None
 1.37A 3vhuA-4oc8A:
undetectable		 3vhuA-4oc8A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		3 / 3 ARG A 324
ARG A 274
TRP A 276
 None
 1.49A 4cpzC-4oc8A:
undetectable		 4cpzC-4oc8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		3 / 3 ARG A 324
ARG A 274
TRP A 276
 None
 1.47A 4cpzH-4oc8A:
undetectable		 4cpzH-4oc8A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		4 / 5 PRO A 229
ASP A 234
ILE A 362
VAL A 377
 None
 0.98A 4hytA-4oc8A:
undetectable		 4hytA-4oc8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		3 / 3 ARG A 324
ASP A 282
TRP A 276
 None
 0.75A 4xdqA-4oc8A:
undetectable		 4xdqA-4oc8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		5 / 12 GLY A 331
THR A 260
PRO A 353
ILE A 322
LEU A 302
 None
 1.05A 5bw4A-4oc8A:
undetectable		 5bw4A-4oc8A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4oc8 RESTRICTION
ENDONUCLEASE ASPBHI
(Azoarcus
sp.
BH72) 		4 / 8 ARG A 217
ALA A 215
GLY A  78
LEU A 213
 None
 0.79A 6mdqA-4oc8A:
undetectable		 6mdqA-4oc8A:
11.02