SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4od5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 9 GLY A 173
ASN A 261
ILE A 242
ALA A 214
VAL A 215
 None
 1.31A 2drdA-4od5A:
undetectable		 2drdA-4od5A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 12 VAL A 137
PHE A  15
SER A  12
VAL A 171
GLY A 130
 None
None
GST  A 301 ( 4.1A)
None
None
 1.19A 2x2iA-4od5A:
undetectable		 2x2iA-4od5A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 10 VAL A 137
PHE A  15
SER A  12
VAL A 171
GLY A 130
 None
None
GST  A 301 ( 4.1A)
None
None
 1.22A 2x2iD-4od5A:
undetectable		 2x2iD-4od5A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 12 GLY A 140
GLY A  19
ALA A 101
PHE A  27
LEU A  97
 None
 1.24A 3vywB-4od5A:
undetectable		 3vywB-4od5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 12 VAL A 171
GLY A 130
VAL A 132
SER A  12
PRO A 265
 None
None
PHB  A 302 (-4.6A)
GST  A 301 ( 4.1A)
None
 1.42A 4bvaA-4od5A:
undetectable		 4bvaA-4od5A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 6 HIS A 128
VAL A 132
LEU A 113
THR A 114
 None
PHB  A 302 (-4.6A)
None
None
 1.19A 5ogjA-4od5A:
undetectable		 5ogjA-4od5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 6 HIS A 128
VAL A 132
LEU A 113
THR A 114
 None
PHB  A 302 (-4.6A)
None
None
 1.19A 5ogjB-4od5A:
undetectable		 5ogjB-4od5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 5 HIS A 128
VAL A 132
LEU A 113
THR A 114
 None
PHB  A 302 (-4.6A)
None
None
 1.19A 5ohhA-4od5A:
undetectable		 5ohhA-4od5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 8 ALA A 231
THR A 235
THR A 238
ALA A 166
 None
 0.89A 5x2tI-4od5A:
undetectable
5x2tJ-4od5A:
undetectable
5x2tK-4od5A:
undetectable
5x2tL-4od5A:
undetectable		 5x2tI-4od5A:
19.93
5x2tJ-4od5A:
18.69
5x2tK-4od5A:
19.93
5x2tL-4od5A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		5 / 8 PRO A  14
VAL A 137
LEU A  22
TYR A 163
ILE A 268
 None
 1.10A 5y1yA-4od5A:
undetectable		 5y1yA-4od5A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E
(Aeropyrum
pernix) 		4 / 8 HIS A 126
PHE A 174
HIS A   8
PHE A 258
 None
None
GST  A 301 ( 4.9A)
None
 0.95A 5y2tB-4od5A:
undetectable		 5y2tB-4od5A:
undetectable