SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4odb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 4odb OUTER CAPSID PROTEIN
SIGMA-1
JUNCTIONAL ADHESION
MOLECULE A
(Mammalian
orthoreovirus;
Homo
sapiens) 		4 / 8 GLN A 396
VAL A 469
GLY D 116
GLY D 115
 None
 0.91A 1ekjE-4odbA:
undetectable
1ekjF-4odbA:
undetectable		 1ekjE-4odbA:
17.47
1ekjF-4odbA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 4odb JUNCTIONAL ADHESION
MOLECULE A
OUTER CAPSID PROTEIN
SIGMA-1
(Homo
sapiens;
Mammalian
orthoreovirus) 		4 / 7 ASN D  76
GLY A 398
THR A 397
SER D 112
 None
 1.20A 2o5yH-4odbD:
13.6
2o5yL-4odbD:
14.4		 2o5yH-4odbD:
19.47
2o5yL-4odbD:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4odb OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 7 ILE A 463
LEU A 367
PHE A 369
ARG A 429
 None
 1.13A 2zxwN-4odbA:
undetectable
2zxwW-4odbA:
undetectable		 2zxwN-4odbA:
13.36
2zxwW-4odbA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4odb OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 5 GLN A 344
PHE A 383
LEU A 441
PHE A 387
 None
 1.44A 3ablC-4odbA:
undetectable
3ablJ-4odbA:
undetectable		 3ablC-4odbA:
19.22
3ablJ-4odbA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4odb OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 TYR A 343
VAL A 456
HIS A 453
THR A 374
 None
 0.88A 3tj7A-4odbA:
undetectable
3tj7B-4odbA:
undetectable		 3tj7A-4odbA:
19.81
3tj7B-4odbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4odb OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 TYR A 343
VAL A 456
HIS A 453
THR A 374
 None
 0.88A 3tj7C-4odbA:
undetectable
3tj7D-4odbA:
undetectable		 3tj7C-4odbA:
19.81
3tj7D-4odbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4odb OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 6 VAL A 456
HIS A 453
THR A 374
TYR A 343
 None
 0.86A 3tj7C-4odbA:
undetectable
3tj7D-4odbA:
undetectable		 3tj7C-4odbA:
19.81
3tj7D-4odbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4odb OUTER CAPSID PROTEIN
SIGMA-1
JUNCTIONAL ADHESION
MOLECULE A
(Mammalian
orthoreovirus;
Homo
sapiens) 		3 / 3 ARG A 333
GLY D 116
GLU D 113
 None
 0.58A 6fgdA-4odbA:
undetectable		 6fgdA-4odbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4odb OUTER CAPSID PROTEIN
SIGMA-1
(Mammalian
orthoreovirus) 		4 / 7 ILE A 463
LEU A 367
ARG A 429
LEU A 341
 None
 0.95A 6nmfA-4odbA:
undetectable
6nmfJ-4odbA:
undetectable		 6nmfA-4odbA:
13.36
6nmfJ-4odbA:
13.25