SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4odi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4odi PHOSPHOGLYCERATE
MUTASE PGMII
(Toxoplasma
gondii) 		4 / 4 SER A 187
ILE A 188
VAL A 196
THR A  89
 None
 1.14A 1u70A-4odiA:
1.7		 1u70A-4odiA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4odi PHOSPHOGLYCERATE
MUTASE PGMII
(Toxoplasma
gondii) 		5 / 11 GLY A 200
SER A 202
ALA A  78
LEU A  75
VAL A 196
 None
 1.02A 1ukbA-4odiA:
undetectable		 1ukbA-4odiA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4odi PHOSPHOGLYCERATE
MUTASE PGMII
(Toxoplasma
gondii) 		5 / 12 LEU A 251
GLY A 226
TYR A 244
ALA A  56
ALA A  57
 None
 1.24A 2br4B-4odiA:
undetectable		 2br4B-4odiA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 4odi PHOSPHOGLYCERATE
MUTASE PGMII
(Toxoplasma
gondii) 		4 / 7 PHE A  67
ILE A  94
THR A  20
GLY A  64
 None
 0.86A 2v0mB-4odiA:
undetectable		 2v0mB-4odiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4odi PHOSPHOGLYCERATE
MUTASE PGMII
(Toxoplasma
gondii) 		5 / 12 ALA A  78
GLY A  39
SER A  73
LEU A 102
SER A 202
 None
 0.98A 3gyqA-4odiA:
undetectable
3gyqB-4odiA:
undetectable		 3gyqA-4odiA:
25.66
3gyqB-4odiA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 4odi PHOSPHOGLYCERATE
MUTASE PGMII
(Toxoplasma
gondii) 		3 / 3 ARG A  36
PHE A  37
GLY A 112
 None
 0.79A 6fgdA-4odiA:
undetectable		 6fgdA-4odiA:
21.86