SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oe5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 342
ALA A 350
SER A 352
HIS A 321
 None
 1.32A 1errA-4oe5A:
undetectable
1errB-4oe5A:
undetectable		 1errA-4oe5A:
17.70
1errB-4oe5A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PRO A 209
THR A 290
PRO A 289
PHE A 284
GLY A 316
 None
 1.32A 1h4oA-4oe5A:
undetectable
1h4oB-4oe5A:
undetectable		 1h4oA-4oe5A:
16.86
1h4oB-4oe5A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 367
THR A 336
VAL A 333
 None
 0.63A 1hxbA-4oe5A:
undetectable		 1hxbA-4oe5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 140
LEU A 144
ALA A 241
GLY A 216
GLY A 217
 None
 0.95A 1k6cA-4oe5A:
undetectable		 1k6cA-4oe5A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP A 460
ASP A 486
THR A 466
TYR A 463
 None
 0.99A 1rmtD-4oe5A:
2.3		 1rmtD-4oe5A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 140
LEU A 144
ALA A 241
GLY A 216
GLY A 217
 None
 0.93A 1sdvA-4oe5A:
undetectable		 1sdvA-4oe5A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 483
SER A 331
GLY A 335
THR A 336
 None
 1.15A 2f7fA-4oe5A:
2.7		 2f7fA-4oe5A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 412
ASP A 438
PRO A 442
SER A 410
 None
 1.32A 2hdnA-4oe5A:
undetectable
2hdnB-4oe5A:
2.1
2hdnD-4oe5A:
undetectable		 2hdnA-4oe5A:
5.92
2hdnB-4oe5A:
20.71
2hdnD-4oe5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 SER A 410
SER A 412
ASP A 438
PRO A 442
 None
 1.39A 2hdnB-4oe5A:
2.0
2hdnC-4oe5A:
undetectable
2hdnD-4oe5A:
2.1		 2hdnB-4oe5A:
20.71
2hdnC-4oe5A:
5.92
2hdnD-4oe5A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  50
ALA A 158
ASP A 161
ILE A 143
ILE A 215
 None
 0.93A 2o4nA-4oe5A:
undetectable		 2o4nA-4oe5A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE A 248
LEU A 249
GLY A 217
ARG A 171
ALA A 132
ALA A 131
 None
 1.28A 2oc8A-4oe5A:
undetectable		 2oc8A-4oe5A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 ILE A 248
LEU A 249
PHE A 170
ARG A 171
ALA A 132
ALA A 131
 None
 1.45A 2oc8A-4oe5A:
undetectable		 2oc8A-4oe5A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 367
THR A 336
VAL A 333
 None
 0.73A 2qakA-4oe5A:
undetectable		 2qakA-4oe5A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X08_A_ASCA1253_0
(CYTOCHROME C
PEROXIDASE,
MITOCHONDRIAL)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ALA A 394
ASP A 393
ILE A 392
PRO A  84
VAL A  82
 None
 1.34A 2x08A-4oe5A:
undetectable		 2x08A-4oe5A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 THR A 290
SER A 208
LYS A 233
 None
 1.02A 3aocC-4oe5A:
undetectable		 3aocC-4oe5A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 THR A 285
ASN A 319
LEU A 478
GLY A 317
PHE A 212
 None
 1.17A 3h9uB-4oe5A:
3.2		 3h9uB-4oe5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ILE A 415
SER A 454
SER A 436
 None
 0.40A 3iltH-4oe5A:
undetectable		 3iltH-4oe5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 404
PHE A 341
GLY A 418
ILE A 415
CYH A 351
 None
 1.47A 3qpsA-4oe5A:
undetectable		 3qpsA-4oe5A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 453
PHE A 320
GLY A 335
ALA A 350
SER A 510
 None
 1.00A 3tbgB-4oe5A:
undetectable		 3tbgB-4oe5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 453
PHE A 320
GLY A 335
ALA A 350
SER A 510
 None
 1.02A 3tbgD-4oe5A:
undetectable		 3tbgD-4oe5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 222
PRO A 223
ARG A 310
ALA A 312
 None
 0.74A 3twpA-4oe5A:
2.8		 3twpA-4oe5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 237
ASN A 211
GLY A 266
GLY A 216
ASN A 283
 None
 1.05A 3v3oA-4oe5A:
3.1		 3v3oA-4oe5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASP A 508
ARG A 338
LYS A 509
 None
 0.95A 3wipG-4oe5A:
undetectable		 3wipG-4oe5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A 438
PRO A 442
SER A 410
SER A 412
 None
 1.06A 4k7gB-4oe5A:
undetectable		 4k7gB-4oe5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER A 331
GLU A 330
ASP A 328
ARG A 367
ILE A 364
 None
 1.35A 4uroD-4oe5A:
undetectable		 4uroD-4oe5A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 453
PHE A 320
GLY A 335
ALA A 350
SER A 510
 None
 1.02A 4wnuA-4oe5A:
1.1		 4wnuA-4oe5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 453
PHE A 320
GLY A 335
ALA A 350
SER A 510
 None
 0.98A 4wnuC-4oe5A:
undetectable		 4wnuC-4oe5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 388
GLY A 344
GLY A 450
LEU A 404
THR A 414
 None
 1.05A 5eqbA-4oe5A:
undetectable		 5eqbA-4oe5A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 285
ASN A 319
LEU A 478
GLY A 317
PHE A 212
 None
 1.15A 6exiA-4oe5A:
undetectable		 6exiA-4oe5A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR A 285
ASN A 319
LEU A 478
GLY A 317
PHE A 212
 None
 1.06A 6exiD-4oe5A:
2.5		 6exiD-4oe5A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PHE A 449
ARG A 399
GLN A 346
 None
 1.10A 6g1pB-4oe5A:
undetectable		 6g1pB-4oe5A:
23.27