SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oe7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		3 / 3 THR A  36
GLU A  59
HIS A 283
 None
 0.91A 1xwfD-4oe7A:
undetectable		 1xwfD-4oe7A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 11 LEU A 306
LEU A 308
ILE A 255
ALA A 272
PHE A 225
 None
 1.19A 2qjuA-4oe7A:
undetectable		 2qjuA-4oe7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QPU_B_QPSB3000_1
(ALPHA-AMYLASE TYPE A
ISOZYME)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 9 ASP A 110
VAL A  85
HIS A 103
ASP A  77
ALA A  72
 None
None
EDO  A 405 ( 3.9A)
None
EDO  A 405 (-3.5A)
 1.40A 2qpuB-4oe7A:
8.8		 2qpuB-4oe7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		4 / 5 PHE A 265
PHE A  52
PHE A 147
ILE A  71
 None
PYR  A 410 (-4.6A)
GXT  A 409 (-4.1A)
None
 1.36A 2v0mD-4oe7A:
undetectable		 2v0mD-4oe7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		4 / 8 GLY A  55
ILE A 269
ASN A 224
GLU A  59
 PYR  A 410 (-3.2A)
None
None
None
 0.82A 2x0pA-4oe7A:
undetectable		 2x0pA-4oe7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 12 SER A  22
PHE A  53
GLY A  55
LEU A  86
VAL A 113
 None
None
PYR  A 410 (-3.2A)
None
None
 1.24A 2zifA-4oe7A:
undetectable		 2zifA-4oe7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 12 SER A  22
PHE A  53
GLY A  55
LEU A  86
VAL A 113
 None
None
PYR  A 410 (-3.2A)
None
None
 1.20A 2zifB-4oe7A:
undetectable		 2zifB-4oe7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 12 THR A  15
GLY A 217
ASP A  49
GLY A 172
LEU A 211
 None
None
EDO  A 403 (-3.8A)
None
None
 1.14A 3eeyF-4oe7A:
2.0		 3eeyF-4oe7A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		4 / 8 ILE A  17
ALA A 218
THR A 210
LEU A 211
 None
 0.64A 3hrdA-4oe7A:
undetectable
3hrdB-4oe7A:
undetectable		 3hrdA-4oe7A:
20.27
3hrdB-4oe7A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		4 / 5 PRO A  19
SER A 220
LEU A  39
SER A  22
 None
 1.27A 3ijxH-4oe7A:
undetectable		 3ijxH-4oe7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		4 / 5 VAL A  21
LEU A  39
ILE A  40
VAL A  48
 None
 0.88A 4a9kB-4oe7A:
undetectable		 4a9kB-4oe7A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		6 / 12 ASN A 224
ILE A 269
GLY A 202
ALA A 218
SER A 220
GLY A 223
 None
None
PYR  A 410 (-4.6A)
None
None
None
 1.45A 4e1gA-4oe7A:
undetectable		 4e1gA-4oe7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		4 / 8 ILE A 115
GLY A  88
VAL A 138
SER A 137
 EDO  A 401 (-3.7A)
EDO  A 401 (-3.2A)
None
None
 0.86A 4r20A-4oe7A:
undetectable		 4r20A-4oe7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 12 GLY A  57
GLU A  59
LEU A 299
LEU A 303
ALA A 226
 PYR  A 410 ( 3.4A)
None
None
None
None
 1.08A 4wcxC-4oe7A:
12.3		 4wcxC-4oe7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		4 / 5 GLU A  99
ALA A  65
GLU A  96
ASN A  93
 None
 1.16A 5dwkC-4oe7A:
undetectable		 5dwkC-4oe7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 11 ASP A 110
ARG A  81
ILE A  18
PHE A  53
PHE A  14
 None
 1.29A 5hwcA-4oe7A:
undetectable		 5hwcA-4oe7A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 12 GLY A 240
VAL A 242
PHE A 208
GLY A 214
GLY A 215
 None
 1.15A 6brdB-4oe7A:
undetectable		 6brdB-4oe7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE
(Escherichia
coli) 		5 / 10 VAL A 134
SER A 137
GLY A  90
GLY A 111
VAL A 142
 None
None
EDO  A 401 (-3.0A)
None
None
 1.12A 6eu9B-4oe7A:
undetectable		 6eu9B-4oe7A:
11.18