SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		4 / 4 THR A 190
LEU A 194
VAL A 197
LEU A 202
 None
 0.83A 1fbmD-4oecA:
undetectable		 1fbmD-4oecA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 ALA A 101
VAL A 128
TRP A   2
 None
 0.92A 1jo3A-4oecA:
undetectable		 1jo3A-4oecA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 ALA A 101
VAL A 128
TRP A   2
 None
 0.92A 1jo3B-4oecA:
undetectable		 1jo3B-4oecA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		4 / 5 LEU A  44
VAL A  51
ARG A  49
THR A  45
 None
 1.20A 1nw3A-4oecA:
undetectable		 1nw3A-4oecA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 ASP A  47
LYS A  69
ARG A  67
 None
 1.15A 1ra8A-4oecA:
undetectable		 1ra8A-4oecA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A  38
ILE A   8
ARG A   4
ALA A  35
VAL A  31
 None
 1.16A 2qhfA-4oecA:
undetectable		 2qhfA-4oecA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 11 PHE A  27
LEU A  44
ALA A 117
GLU A  39
LEU A  90
 None
None
None
MG  A 401 (-2.6A)
None
 1.43A 2v0mA-4oecA:
undetectable		 2v0mA-4oecA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 106
HIS A  12
GLU A  39
 MG  A 401 (-2.8A)
None
MG  A 401 (-2.6A)
 0.76A 2x45B-4oecA:
undetectable		 2x45B-4oecA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A 106
HIS A  12
GLU A  39
 MG  A 401 (-2.8A)
None
MG  A 401 (-2.6A)
 0.77A 2x45C-4oecA:
undetectable		 2x45C-4oecA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  93
THR A 149
THR A 148
ASN A 104
ILE A 130
 None
 1.22A 3a35A-4oecA:
undetectable		 3a35A-4oecA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 130
ALA A 137
GLU A  39
ASN A  22
LEU A  40
 None
None
MG  A 401 (-2.6A)
None
None
 1.37A 3eigA-4oecA:
undetectable		 3eigA-4oecA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  50
LEU A 107
VAL A  42
ILE A 130
THR A 148
 None
 1.37A 3frqA-4oecA:
undetectable		 3frqA-4oecA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 10 GLU A  91
LEU A  90
VAL A  50
ILE A 130
LEU A 107
 None
 1.20A 3jw5B-4oecA:
undetectable		 3jw5B-4oecA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		4 / 6 VAL A  93
VAL A 128
ILE A 119
ARG A  13
 None
 1.13A 3mssC-4oecA:
undetectable		 3mssC-4oecA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  14
GLY A  11
GLU A  21
ALA A  26
TYR A  19
 None
 1.44A 3t7sC-4oecA:
undetectable		 3t7sC-4oecA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 ARG A  99
GLU A  95
ASN A 123
 None
 0.86A 4imaD-4oecA:
13.0		 4imaD-4oecA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 ARG A  99
GLU A  95
ASN A 123
 None
 0.89A 4ip7D-4oecA:
5.4		 4ip7D-4oecA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 9 ALA A 101
ILE A 231
GLY A  14
ALA A  30
VAL A   9
 None
 1.28A 4r1zA-4oecA:
undetectable		 4r1zA-4oecA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		4 / 7 PRO A 178
GLU A 180
TRP A  43
THR A  61
 None
 1.17A 4uacA-4oecA:
undetectable		 4uacA-4oecA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 GLU A  39
TRP A 207
ASN A 233
 MG  A 401 (-2.6A)
None
None
 0.81A 5dv4A-4oecA:
undetectable		 5dv4A-4oecA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		4 / 4 LEU A 153
ILE A 154
GLY A 151
ILE A 163
 None
 0.81A 5dzk3-4oecA:
undetectable
5dzkm-4oecA:
3.1		 5dzk3-4oecA:
1.31
5dzkm-4oecA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		4 / 5 ILE A 154
GLY A 151
ILE A 163
LEU A 153
 None
 0.84A 5dzkB-4oecA:
3.2
5dzkI-4oecA:
1.5
5dzkW-4oecA:
undetectable		 5dzkB-4oecA:
21.11
5dzkI-4oecA:
19.84
5dzkW-4oecA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		4 / 5 ILE A 154
GLY A 151
ILE A 163
LEU A 153
 None
 0.83A 5dzki-4oecA:
undetectable
5dzkj-4oecA:
undetectable
5dzkx-4oecA:
undetectable		 5dzki-4oecA:
19.84
5dzkj-4oecA:
19.84
5dzkx-4oecA:
1.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		4 / 7 PHE A 214
ASP A 211
GLY A  11
HIS A  12
 None
 0.83A 5n9xA-4oecA:
undetectable		 5n9xA-4oecA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 ASP A 155
ARG A 156
ASP A 134
 None
 0.90A 5zvgB-4oecA:
undetectable		 5zvgB-4oecA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 232
VAL A 230
PHE A 227
ALA A 221
LEU A 242
 None
 1.00A 6h1lA-4oecA:
undetectable		 6h1lA-4oecA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE
(Thermococcus
kodakarensis) 		3 / 3 TRP A 207
ILE A 154
ASP A 155
 None
 0.79A 6i0y7-4oecA:
undetectable		 6i0y7-4oecA:
6.72