SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 THR A  99
PHE A 113
PHE A  68
GLY A 115
 None
 1.17A 1kqbA-4oemA:
undetectable
1kqbB-4oemA:
undetectable		 1kqbA-4oemA:
21.24
1kqbB-4oemA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA A   4
TYR A  83
TYR A 235
PHE A  80
 None
 1.17A 2ajvH-4oemA:
undetectable
2ajvL-4oemA:
undetectable		 2ajvH-4oemA:
20.21
2ajvL-4oemA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ARG A 226
GLN A 262
PRO A 261
 None
 0.91A 2qhfA-4oemA:
undetectable		 2qhfA-4oemA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN
(Homo
sapiens) 		4 / 5 PHE A 113
SER A 268
PHE A  68
ILE A 282
 None
EDO  A 509 (-4.1A)
None
None
 1.05A 2v0mD-4oemA:
undetectable		 2v0mD-4oemA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN
(Homo
sapiens) 		5 / 12 PHE A  80
SER A 268
THR A  97
ILE A 282
ALA A 287
 None
EDO  A 509 (-4.1A)
None
None
None
 1.17A 3nxuB-4oemA:
undetectable		 3nxuB-4oemA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN
(Homo
sapiens) 		4 / 5 ILE A 249
ILE A 219
HIS A 217
VAL A 216
 None
 0.94A 5jmnA-4oemA:
undetectable		 5jmnA-4oemA:
16.46