SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		5 / 12 PHE A 277
ASN A 354
GLY A 447
SER A 335
ILE A 446
 ACT  A 507 (-3.4A)
None
None
ACT  A 506 (-3.4A)
None
 1.31A 2e7fB-4oenA:
undetectable		 2e7fB-4oenA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		5 / 12 PHE A 277
ASN A 354
GLY A 447
SER A 335
ILE A 446
 ACT  A 507 (-3.4A)
None
None
ACT  A 506 (-3.4A)
None
 1.34A 2ogyA-4oenA:
undetectable		 2ogyA-4oenA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		5 / 10 ILE A 297
ALA A 332
ILE A 271
PHE A 451
TYR A 350
 None
ACT  A 507 (-4.3A)
None
None
None
 1.18A 2w9sC-4oenA:
undetectable		 2w9sC-4oenA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		5 / 12 PHE A 277
ASN A 354
GLY A 447
SER A 335
ILE A 446
 ACT  A 507 (-3.4A)
None
None
ACT  A 506 (-3.4A)
None
 1.29A 2ycjA-4oenA:
undetectable		 2ycjA-4oenA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		5 / 10 TYR A 350
ILE A 481
ILE A 292
GLY A 333
LEU A 469
 None
None
None
ACT  A 507 (-4.7A)
None
 1.18A 3elzB-4oenA:
undetectable		 3elzB-4oenA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		5 / 10 TYR A 350
ILE A 481
ILE A 292
GLY A 333
LEU A 469
 None
None
None
ACT  A 507 (-4.7A)
None
 1.31A 3em0A-4oenA:
undetectable		 3em0A-4oenA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		4 / 5 LEU A 437
GLY A 358
ILE A 417
VAL A 376
 None
 0.88A 3wrkA-4oenA:
undetectable		 3wrkA-4oenA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		4 / 7 PHE A 306
ASN A 466
GLY A 468
ILE A 297
 None
 0.88A 4ejjA-4oenA:
undetectable		 4ejjA-4oenA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		5 / 12 LEU A 357
ILE A 417
TYR A 409
LEU A 437
GLY A 415
 None
 1.24A 4l9qA-4oenA:
undetectable		 4l9qA-4oenA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		5 / 12 GLY A 329
ILE A 310
ILE A 462
ASN A 466
PHE A 465
 None
 1.05A 5fa8A-4oenA:
undetectable		 5fa8A-4oenA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		3 / 3 THR A 337
ASP A 338
ALA A 339
 ACT  A 505 (-4.2A)
ACT  A 505 (-4.0A)
ACT  A 505 (-3.6A)
 0.10A 5g5gB-4oenA:
undetectable		 5g5gB-4oenA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER
(Streptococcus
pneumoniae) 		4 / 5 TYR A 397
VAL A 376
ASP A 418
ALA A 419
 None
 1.10A 5otrA-4oenA:
undetectable		 5otrA-4oenA:
20.19