SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 5 TYR A  32
PRO A  34
LEU A  35
THR A  88
 None
 1.15A 1i2wA-4oerA:
undetectable		 1i2wA-4oerA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 12 LEU A 342
LEU A 362
ALA A 262
ALA A 266
VAL A 358
 None
 1.03A 1kt4A-4oerA:
undetectable		 1kt4A-4oerA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 11 LEU A 342
LEU A 362
ALA A 262
VAL A 358
LEU A 463
 None
 1.24A 1kt7A-4oerA:
undetectable		 1kt7A-4oerA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 10 LEU A 362
ALA A 262
ALA A 266
VAL A 358
LEU A 463
 None
 1.02A 1rlbE-4oerA:
undetectable		 1rlbE-4oerA:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 5 TRP A   8
PRO A   9
GLY A 217
GLY A 220
 None
None
GOL  A 605 (-3.4A)
None
 0.87A 1zlqA-4oerA:
37.9		 1zlqA-4oerA:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 8 TYR A  20
MET A  25
TRP A  98
ARG A 135
 GOL  A 608 ( 4.5A)
GOL  A 601 (-3.5A)
GOL  A 608 (-3.8A)
None
 0.58A 1zlqB-4oerA:
48.6		 1zlqB-4oerA:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 8 TYR A  20
TRP A  98
ARG A 135
TYR A 400
 GOL  A 608 ( 4.5A)
GOL  A 608 (-3.8A)
None
None
 0.78A 1zlqB-4oerA:
48.6		 1zlqB-4oerA:
64.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 12 LEU A 133
LEU A 101
MET A 105
LEU A  90
THR A 150
 None
 1.40A 2aa6B-4oerA:
undetectable		 2aa6B-4oerA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 4oer NIKA PROTEIN
(Brucella
suis) 		3 / 3 ASN A  29
TYR A 400
SER A 487
 None
None
GOL  A 601 ( 2.7A)
 0.93A 2gvcB-4oerA:
undetectable		 2gvcB-4oerA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 6 MET A 354
ARG A 287
PRO A 224
GLY A 283
 None
SO4  A 609 (-2.5A)
None
None
 1.35A 3aqiA-4oerA:
undetectable		 3aqiA-4oerA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 6 MET A 354
ARG A 287
PRO A 224
GLY A 283
 None
SO4  A 609 (-2.5A)
None
None
 1.40A 3aqiB-4oerA:
undetectable		 3aqiB-4oerA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 10 ASP A 416
ALA A 415
VAL A 406
LEU A 291
PHE A 292
 None
 1.22A 3ay0A-4oerA:
undetectable		 3ay0A-4oerA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 11 LEU A 456
ALA A 419
PHE A 388
ALA A 415
MET A 409
 None
 1.42A 3bszF-4oerA:
undetectable		 3bszF-4oerA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 4oer NIKA PROTEIN
(Brucella
suis) 		3 / 3 MET A 233
VAL A 473
GLU A 228
 None
 0.71A 3c6gA-4oerA:
undetectable		 3c6gA-4oerA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 7 ASP A 451
GLN A 446
GLN A 435
GLU A 432
 None
 1.16A 3l2vA-4oerA:
undetectable		 3l2vA-4oerA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 4 ALA A 262
VAL A 263
ASP A 260
LEU A 338
 None
 1.23A 4e7gA-4oerA:
undetectable		 4e7gA-4oerA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 8 ILE A 490
ILE A 481
ALA A 474
VAL A 194
 None
 0.80A 4jltA-4oerA:
undetectable		 4jltA-4oerA:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OES_A_EDTA601_0
(NIKA PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 6 TYR A  20
MET A  25
TRP A  98
ARG A 135
 GOL  A 608 ( 4.5A)
GOL  A 601 (-3.5A)
GOL  A 608 (-3.8A)
None
 0.33A 4oesA-4oerA:
52.9		 4oesA-4oerA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OES_A_EDTA601_0
(NIKA PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 6 TYR A  20
TRP A  98
ARG A 135
TYR A 400
 GOL  A 608 ( 4.5A)
GOL  A 608 (-3.8A)
None
None
 0.68A 4oesA-4oerA:
52.9		 4oesA-4oerA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 6 PHE A 207
ARG A 229
THR A 226
ILE A 215
 None
 1.35A 5ih0A-4oerA:
undetectable		 5ih0A-4oerA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4oer NIKA PROTEIN
(Brucella
suis) 		3 / 3 VAL A 461
ARG A 445
PRO A 402
 None
GOL  A 606 ( 4.4A)
None
 0.85A 5koxA-4oerA:
1.3		 5koxA-4oerA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 8 TYR A  20
MET A  25
TRP A  98
ARG A 135
TYR A 400
 GOL  A 608 ( 4.5A)
GOL  A 601 (-3.5A)
GOL  A 608 (-3.8A)
None
None
 0.84A 5l8dA-4oerA:
38.6		 5l8dA-4oerA:
64.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 10 ILE A 140
ILE A 154
THR A  88
ASN A  92
ASP A 152
 None
 1.28A 5lg3G-4oerA:
undetectable		 5lg3G-4oerA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 5 ARG A 445
THR A 443
ALA A 444
ASP A 441
 GOL  A 606 ( 4.4A)
None
None
None
 1.30A 5mfxA-4oerA:
undetectable		 5mfxA-4oerA:
23.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 8 TYR A  20
MET A  25
TRP A  98
ARG A 135
TYR A 400
 GOL  A 608 ( 4.5A)
GOL  A 601 (-3.5A)
GOL  A 608 (-3.8A)
None
None
 0.84A 5mwuA-4oerA:
38.6		 5mwuA-4oerA:
64.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4oer NIKA PROTEIN
(Brucella
suis) 		5 / 12 GLN A 420
VAL A 406
ARG A 455
ILE A 452
ASP A 451
 None
 1.40A 6bxnA-4oerA:
undetectable		 6bxnA-4oerA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4oer NIKA PROTEIN
(Brucella
suis) 		4 / 6 THR A 226
PRO A 200
ARG A 203
ILE A 215
 None
 1.16A 6ef6A-4oerA:
0.9		 6ef6A-4oerA:
20.40