SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4of0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 6 ALA A 142
SER A 229
ARG A 236
LEU A 266
 None
 1.12A 1gahA-4of0A:
undetectable		 1gahA-4of0A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 11 SER A 229
TRP A 165
ILE A 245
ALA A 166
LEU A 180
 None
 1.46A 1jb0B-4of0A:
undetectable		 1jb0B-4of0A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 11 TRP A 165
ILE A 245
ALA A 166
LEU A 180
ALA A 203
 None
 1.48A 1jb0B-4of0A:
undetectable		 1jb0B-4of0A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 4 VAL A 201
ALA A 203
LEU A 244
PHE A 233
 None
 1.21A 1q97B-4of0A:
undetectable		 1q97B-4of0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 11 SER A 229
TRP A 165
ILE A 245
ALA A 166
LEU A 180
 None
 1.46A 3pcqB-4of0A:
undetectable		 3pcqB-4of0A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 11 TRP A 165
ILE A 245
ALA A 166
LEU A 180
ALA A 203
 None
 1.48A 3pcqB-4of0A:
undetectable		 3pcqB-4of0A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		3 / 3 GLN A 210
THR A 209
THR A 208
 None
 0.83A 4fu9A-4of0A:
undetectable		 4fu9A-4of0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		3 / 3 GLN A 210
THR A 209
THR A 208
 None
 0.82A 4fufA-4of0A:
undetectable		 4fufA-4of0A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		4 / 5 THR A  95
GLY A  37
GLU A  90
ASP A  98
 None
 1.25A 5c0oH-4of0A:
undetectable		 5c0oH-4of0A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 10 SER A 229
TRP A 165
ILE A 245
ALA A 166
LEU A 180
 None
 1.48A 5oy0b-4of0A:
undetectable		 5oy0b-4of0A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4of0 PROTEIN SYG-1,
ISOFORM B
(Caenorhabditis
elegans) 		5 / 9 SER A 229
TRP A 165
ILE A 245
ALA A 166
LEU A 180
 None
 1.42A 6hqbB-4of0A:
undetectable		 6hqbB-4of0A:
14.17