SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ofl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		3 / 3 TRP A 385
VAL A 287
TRP A 456
 HIS  A 502 (-3.9A)
None
None
 1.16A 1c4dA-4oflA:
undetectable
1c4dB-4oflA:
undetectable		 1c4dA-4oflA:
2.88
1c4dB-4oflA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 8 ASN A 293
LEU A 290
LEU A 393
TYR A 397
 None
 0.88A 1hk2A-4oflA:
undetectable		 1hk2A-4oflA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 8 GLN A 288
LEU A 290
LEU A 393
TYR A 397
 None
 0.98A 1hk2A-4oflA:
undetectable		 1hk2A-4oflA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 GLY A 149
GLY A 151
ILE A 132
ASP A  81
PHE A  17
 None
 1.09A 1ri4A-4oflA:
undetectable		 1ri4A-4oflA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 ILE A 183
LEU A 182
HIS A   3
GLY A 202
LEU A 474
 None
 1.06A 2a58A-4oflA:
2.0
2a58B-4oflA:
2.0		 2a58A-4oflA:
16.39
2a58B-4oflA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 ILE A 183
LEU A 182
HIS A   3
GLY A 202
LEU A 474
 None
 1.05A 2a58B-4oflA:
2.0
2a58C-4oflA:
2.0		 2a58B-4oflA:
16.39
2a58C-4oflA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 ILE A 183
LEU A 182
HIS A   3
GLY A 202
LEU A 474
 None
 1.06A 2a58D-4oflA:
undetectable
2a58E-4oflA:
undetectable		 2a58D-4oflA:
16.39
2a58E-4oflA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 9 LEU A 335
ARG A 352
LEU A 382
LEU A 459
ALA A 350
 None
 1.14A 2bxeA-4oflA:
undetectable		 2bxeA-4oflA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 SER A  33
PRO A 170
ASP A 492
TYR A 172
LEU A 182
 None
 1.48A 2c7vB-4oflA:
undetectable		 2c7vB-4oflA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 SER A  33
PRO A 170
ASP A 492
TYR A 172
LEU A 182
 None
 1.47A 2c7vC-4oflA:
undetectable		 2c7vC-4oflA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 ILE A 450
ALA A 457
ALA A 265
LEU A 311
ILE A 358
 None
 1.06A 2h79A-4oflA:
undetectable		 2h79A-4oflA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 LEU A 393
ASP A 418
THR A 446
GLY A 447
GLY A 452
 None
 1.17A 2uvnA-4oflA:
undetectable		 2uvnA-4oflA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 10 PHE A 193
SER A 214
ASN A 217
GLY A 199
ALA A 196
 None
 1.42A 2x2iB-4oflA:
undetectable		 2x2iB-4oflA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 7 TRP A 369
VAL A 372
THR A 381
LEU A 382
 HIS  A 502 (-3.3A)
None
None
None
 1.23A 3arrA-4oflA:
undetectable		 3arrA-4oflA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 ILE A 450
ALA A 457
ALA A 265
LEU A 311
ILE A 358
 None
 1.09A 3gwsX-4oflA:
undetectable		 3gwsX-4oflA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 11 PHE A 184
LEU A   7
TYR A 153
LEU A 488
ILE A 491
 None
 1.41A 3o94C-4oflA:
undetectable		 3o94C-4oflA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 11 PHE A 184
LEU A   7
TYR A 153
LEU A 488
ILE A 491
 None
 1.40A 3o94D-4oflA:
undetectable		 3o94D-4oflA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 4 PHE A 383
TYR A 407
ILE A 462
LEU A 460
 HIS  A 502 (-4.6A)
None
None
None
 1.47A 3sudA-4oflA:
undetectable		 3sudA-4oflA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 8 TYR A 138
TYR A 143
HIS A  32
LEU A 130
 None
 1.02A 3uzzB-4oflA:
undetectable		 3uzzB-4oflA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 8 TYR A 138
TYR A 143
LEU A 130
MET A  98
 None
 1.32A 3uzzB-4oflA:
undetectable		 3uzzB-4oflA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 7 PRO A  54
SER A  55
VAL A 124
TRP A  61
 None
 1.47A 4kmmA-4oflA:
undetectable		 4kmmA-4oflA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 ALA A 457
LEU A 355
ASN A 250
PHE A 233
ILE A 258
 None
 1.28A 4pb1A-4oflA:
undetectable		 4pb1A-4oflA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 ALA A 457
LEU A 355
PHE A 233
ASN A 250
ILE A 258
 None
 1.12A 4pb1A-4oflA:
undetectable		 4pb1A-4oflA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 12 ALA A 457
LEU A 355
PHE A 233
ASN A 250
ILE A 258
 None
 1.12A 4pd9A-4oflA:
undetectable		 4pd9A-4oflA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		3 / 3 VAL A 133
ALA A 135
PHE A  71
 None
 0.48A 4z4iA-4oflA:
undetectable		 4z4iA-4oflA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		3 / 3 VAL A 133
ALA A 135
PHE A  71
 None
 0.51A 5js1A-4oflA:
undetectable		 5js1A-4oflA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		5 / 10 LEU A 355
ILE A 258
ALA A 261
ILE A 262
ILE A 310
 None
 0.98A 5mvmD-4oflA:
undetectable
5mvmE-4oflA:
undetectable		 5mvmD-4oflA:
7.94
5mvmE-4oflA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 6 THR A 342
ARG A 345
ILE A 275
GLU A 277
 None
 1.16A 5uigA-4oflA:
undetectable		 5uigA-4oflA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		3 / 3 GLU A 392
TRP A 458
HIS A 482
 None
None
NI  A 501 (-3.4A)
 0.87A 5xipA-4oflA:
2.2		 5xipA-4oflA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA
(Yersinia
pestis) 		4 / 6 GLY A 367
THR A 381
VAL A 372
TRP A 369
 None
None
None
HIS  A 502 (-3.3A)
 0.96A 5ysiA-4oflA:
undetectable		 5ysiA-4oflA:
15.00