SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ofq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.14A 1dz4A-4ofqA:
undetectable		 1dz4A-4ofqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.12A 1dz4B-4ofqA:
undetectable		 1dz4B-4ofqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 5 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.14A 1t88B-4ofqA:
undetectable		 1t88B-4ofqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		5 / 12 LEU A1259
GLY A1269
SER A1266
ALA A1270
ALA A1272
 None
 1.14A 2bm9D-4ofqA:
undetectable		 2bm9D-4ofqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 5 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.16A 2m56A-4ofqA:
undetectable		 2m56A-4ofqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		5 / 12 PRO A1083
THR A1130
VAL A1027
ILE A1133
SER A1079
 None
 1.40A 2xpvA-4ofqA:
undetectable		 2xpvA-4ofqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.14A 2zawA-4ofqA:
undetectable		 2zawA-4ofqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		5 / 12 TYR A1197
ILE A1221
GLY A1183
LEU A1252
LEU A1259
 None
 0.99A 3em0B-4ofqA:
undetectable		 3em0B-4ofqA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.08A 3fwgA-4ofqA:
undetectable		 3fwgA-4ofqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 7 ASP A1108
ASP A1006
GLN A 975
TYR A1139
 None
 1.19A 3l2vA-4ofqA:
undetectable		 3l2vA-4ofqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		5 / 12 TYR A1288
ALA A1270
TRP A1184
ASP A1234
LEU A1235
 None
 1.37A 3ou6D-4ofqA:
undetectable		 3ou6D-4ofqA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 8 ASP A1108
ASP A1006
GLN A 975
TYR A1139
 None
 1.14A 3oyaA-4ofqA:
undetectable		 3oyaA-4ofqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.09A 3wrhE-4ofqA:
undetectable		 3wrhE-4ofqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.09A 3wrjE-4ofqA:
undetectable		 3wrjE-4ofqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.11A 4ek1A-4ofqA:
undetectable		 4ek1A-4ofqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.15A 4g3rB-4ofqA:
undetectable		 4g3rB-4ofqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		5 / 12 VAL A1215
LEU A1181
VAL A1274
PHE A1199
LEU A1252
 None
 1.14A 4i1rA-4ofqA:
undetectable		 4i1rA-4ofqA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 6 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.13A 4kkyX-4ofqA:
undetectable		 4kkyX-4ofqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 5 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.12A 4l49A-4ofqA:
undetectable		 4l49A-4ofqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 8 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.06A 4l4dA-4ofqA:
undetectable		 4l4dA-4ofqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 8 GLY A1269
ALA A1270
ASP A1271
GLY A1232
 None
 0.64A 5kr1B-4ofqA:
undetectable		 5kr1B-4ofqA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4ofq PUTATIVE CELL
SURFACE PROTEIN
(Streptococcus
pyogenes) 		4 / 8 TYR A1111
LEU A1057
VAL A1053
VAL A1103
 None
 1.09A 6cp4A-4ofqA:
undetectable		 6cp4A-4ofqA:
20.67