SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ofx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 11 ILE A  46
GLY A 183
THR A 184
HIS A 156
GLY A 180
 None
 1.11A 1i7qA-4ofxA:
undetectable		 1i7qA-4ofxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 10 ILE A  46
GLY A 183
THR A 184
HIS A 156
GLY A 180
 None
 1.13A 1i7qC-4ofxA:
undetectable		 1i7qC-4ofxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		4 / 5 LEU A 293
VAL A 273
ALA A 280
CYH A 277
 None
 1.16A 1mz9D-4ofxA:
undetectable		 1mz9D-4ofxA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		4 / 4 LEU A 293
VAL A 291
CYH A 289
ALA A 280
 None
 1.22A 1mz9E-4ofxA:
undetectable		 1mz9E-4ofxA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		6 / 12 LEU A  80
GLN A 146
ILE A  10
VAL A  42
GLY A  40
GLY A  39
 None
 1.12A 1uakA-4ofxA:
undetectable		 1uakA-4ofxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		3 / 3 GLY A  77
ASP A  44
SER A  41
 None
 0.64A 3brfA-4ofxA:
undetectable		 3brfA-4ofxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 12 ALA A 276
LEU A  18
LEU A  29
LEU A 290
LEU A 257
 None
 1.21A 3erdA-4ofxA:
undetectable		 3erdA-4ofxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 9 ALA A 272
ILE A 243
GLY A 203
ILE A 185
LEU A 290
 None
 1.22A 3u7sB-4ofxA:
undetectable		 3u7sB-4ofxA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 9 ALA A 272
ILE A 243
GLY A 203
ILE A 185
LEU A 290
 None
 1.11A 3u7sA-4ofxA:
undetectable		 3u7sA-4ofxA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		4 / 4 GLU A 163
GLY A 161
HIS A 156
ARG A  45
 None
 1.22A 4r82A-4ofxA:
undetectable
4r82B-4ofxA:
undetectable		 4r82A-4ofxA:
20.50
4r82B-4ofxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		4 / 7 GLY A  77
GLN A 146
ALA A  81
ILE A  51
 None
 0.91A 4txnA-4ofxA:
undetectable		 4txnA-4ofxA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		4 / 7 GLY A  77
GLN A 146
ALA A  81
ILE A  51
 None
 0.90A 4txnB-4ofxA:
undetectable		 4txnB-4ofxA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		4 / 7 GLY A  77
GLN A 146
ALA A  81
ILE A  51
 None
 0.93A 4txnC-4ofxA:
undetectable		 4txnC-4ofxA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		4 / 7 GLY A  77
GLN A 146
ALA A  81
ILE A  51
 None
 0.89A 4txnD-4ofxA:
undetectable		 4txnD-4ofxA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 12 VAL A 176
ALA A 276
ARG A 288
ARG A 282
LEU A 283
 None
 1.36A 5nd2B-4ofxA:
undetectable		 5nd2B-4ofxA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		4 / 6 GLY A  31
TYR A  30
LEU A 263
VAL A 273
 None
 0.94A 5x80A-4ofxA:
undetectable
5x80B-4ofxA:
undetectable		 5x80A-4ofxA:
20.89
5x80B-4ofxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 9 ASN A  73
ILE A 292
SER A 268
SER A 269
THR A 160
 None
 1.37A 6awpA-4ofxA:
undetectable		 6awpA-4ofxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 10 GLY A  77
GLY A  47
ILE A  76
ALA A  81
GLY A  39
 None
 1.04A 6e5zA-4ofxA:
undetectable		 6e5zA-4ofxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4ofx CYSTATHIONINE
BETA-SYNTHASE
(Coxiella
burnetii) 		5 / 7 VAL A 291
LEU A  29
LEU A  25
LEU A 257
MET A 253
 None
 1.49A 6g9bA-4ofxA:
undetectable
6g9bB-4ofxA:
undetectable		 6g9bA-4ofxA:
12.50
6g9bB-4ofxA:
14.10