SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ofy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		3 / 3 LEU D  70
PRO D  71
LEU D  62
 None
 0.48A 2qd5B-4ofyD:
undetectable		 2qd5B-4ofyD:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		5 / 12 VAL D 228
ILE D 150
VAL D 196
LEU D 148
VAL D 142
 None
 1.13A 3w68C-4ofyD:
undetectable		 3w68C-4ofyD:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		5 / 9 ALA D 412
ILE D 363
GLN D 377
VAL D 387
SER D 354
 None
 1.30A 4a3uA-4ofyD:
undetectable		 4a3uA-4ofyD:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		4 / 6 GLU D 215
GLN D 213
VAL D 154
THR D 189
 None
 1.39A 4lnxA-4ofyD:
undetectable		 4lnxA-4ofyD:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		4 / 5 VAL D 252
LEU D 246
ILE D 239
LEU D 240
 None
 0.85A 4mghA-4ofyD:
undetectable		 4mghA-4ofyD:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		5 / 12 ILE D 254
ALA D 297
ARG D 241
ASP D 250
LEU D 246
 None
 1.44A 4pbhA-4ofyD:
undetectable		 4pbhA-4ofyD:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		4 / 8 ARG D  76
VAL D  94
ASP D  97
ASP D  98
 None
 1.00A 4xqgA-4ofyD:
undetectable		 4xqgA-4ofyD:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		4 / 8 ARG D  76
VAL D  94
ASP D  97
ASP D  98
 None
 1.00A 4xqgB-4ofyD:
undetectable		 4xqgB-4ofyD:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ofy PROTEIN SYG-2
(Caenorhabditis
elegans) 		4 / 8 ILE D 218
ALA D 211
VAL D 163
ARG D 219
 None
 0.93A 6hu9a-4ofyD:
undetectable
6hu9e-4ofyD:
undetectable		 6hu9a-4ofyD:
19.48
6hu9e-4ofyD:
13.59