SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ofz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		3 / 3 TRP A 280
VAL A 335
TRP A 396
 None
 1.38A 1gmkC-4ofzA:
undetectable
1gmkD-4ofzA:
undetectable		 1gmkC-4ofzA:
3.75
1gmkD-4ofzA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 6 ALA A 267
LEU A 100
ASP A  96
LEU A  92
 None
 0.93A 1mt1D-4ofzA:
undetectable
1mt1E-4ofzA:
undetectable		 1mt1D-4ofzA:
12.65
1mt1E-4ofzA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		5 / 12 MET A  75
LEU A 229
ILE A 130
MET A 119
GLN A 224
 None
 1.29A 1xomB-4ofzA:
undetectable		 1xomB-4ofzA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 6 LEU A 405
ILE A 406
ARG A 247
VAL A  83
 None
 1.08A 2ygoA-4ofzA:
undetectable		 2ygoA-4ofzA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		5 / 12 PHE A 197
GLY A 417
ILE A 209
LYS A 207
THR A 204
 None
 1.42A 3a25A-4ofzA:
undetectable		 3a25A-4ofzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		3 / 3 LYS A  69
LYS A 323
VAL A  65
 None
 0.99A 3brfA-4ofzA:
undetectable		 3brfA-4ofzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		5 / 12 LEU A 172
HIS A 478
ASP A 475
ASP A 140
GLY A 237
 None
 1.44A 3g1uC-4ofzA:
2.5		 3g1uC-4ofzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 8 ALA A 254
GLY A 255
GLN A 332
THR A 339
 None
 0.84A 3rglA-4ofzA:
undetectable		 3rglA-4ofzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 5 THR A 253
GLY A 278
PRO A 256
TYR A 225
 None
 1.28A 3u8qA-4ofzA:
undetectable		 3u8qA-4ofzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		3 / 3 SER A 277
ASP A 215
ASP A 220
 None
 0.88A 4mwzA-4ofzA:
undetectable		 4mwzA-4ofzA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		3 / 3 ASN A 228
ASP A 132
ASP A 140
 None
 0.88A 4obwD-4ofzA:
undetectable		 4obwD-4ofzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		3 / 3 GLU A 386
ILE A 395
ALA A 389
 None
 0.64A 4wnwB-4ofzA:
undetectable		 4wnwB-4ofzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 8 SER A 279
GLY A 278
ALA A 226
GLY A 261
 None
 0.90A 5albL-4ofzA:
undetectable		 5albL-4ofzA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		5 / 10 LEU A 413
GLY A 401
GLY A 399
ILE A 248
ALA A 250
 None
 0.93A 5l0zB-4ofzA:
undetectable		 5l0zB-4ofzA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		3 / 3 LEU A 265
LEU A 263
TRP A 285
 None
 0.87A 5nwuA-4ofzA:
undetectable		 5nwuA-4ofzA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 7 THR A  64
PHE A  68
LEU A 326
SER A 223
 None
 1.31A 5uxcA-4ofzA:
undetectable		 5uxcA-4ofzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		5 / 12 MET A 238
ALA A 242
SER A 244
LEU A 485
ILE A 484
 None
 1.12A 5vlmA-4ofzA:
undetectable		 5vlmA-4ofzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 7 GLY A 216
GLN A 224
ASP A 132
ASP A 475
 None
 1.03A 5vlmE-4ofzA:
undetectable		 5vlmE-4ofzA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 6 HIS A 347
ASN A 355
VAL A 342
LEU A 383
 None
 1.49A 5xdhA-4ofzA:
undetectable
5xdhC-4ofzA:
undetectable		 5xdhA-4ofzA:
9.11
5xdhC-4ofzA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 5 HIS A 347
ASN A 355
VAL A 342
LEU A 383
 None
 1.48A 5xdhD-4ofzA:
undetectable		 5xdhD-4ofzA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 5 ILE A  99
GLN A  76
THR A  78
LEU A 141
 None
 1.02A 6f3mD-4ofzA:
5.0		 6f3mD-4ofzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ofz TREHALOSE-PHOSPHATAS
E
(Brugia
malayi) 		4 / 8 GLN A 230
ILE A 171
ALA A 479
VAL A 476
 None
 1.08A 6hu9a-4ofzA:
undetectable
6hu9e-4ofzA:
1.0		 6hu9a-4ofzA:
20.79
6hu9e-4ofzA:
14.83