SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4og1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 ALA A 154
VAL A 125
TRP A 103
 None
 0.87A 1av2A-4og1A:
undetectable
1av2B-4og1A:
undetectable		 1av2A-4og1A:
7.56
1av2B-4og1A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 TRP A 103
ALA A 154
VAL A 125
 None
 0.96A 1av2C-4og1A:
undetectable
1av2D-4og1A:
undetectable		 1av2C-4og1A:
7.56
1av2D-4og1A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A   7
ALA A  35
PHE A  37
GLY A  39
 None
 1.30A 1mj2B-4og1A:
undetectable		 1mj2B-4og1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A   7
ALA A  35
PHE A  37
GLY A  39
 None
 1.37A 1mj2D-4og1A:
undetectable		 1mj2D-4og1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A   7
ALA A  35
PHE A  37
GLY A  39
 None
 1.33A 1mjoB-4og1A:
undetectable		 1mjoB-4og1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A   7
ALA A  35
PHE A  37
GLY A  39
 None
 1.35A 1mjoA-4og1A:
undetectable		 1mjoA-4og1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 4 HIS A   7
ALA A  35
PHE A  37
GLY A  39
 None
 1.32A 1mjoD-4og1A:
undetectable		 1mjoD-4og1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 ALA A 154
VAL A 125
TRP A 103
 None
 0.88A 1w5uA-4og1A:
undetectable
1w5uB-4og1A:
undetectable		 1w5uA-4og1A:
7.56
1w5uB-4og1A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 TRP A 103
ALA A 154
VAL A 125
 None
 0.93A 1w5uA-4og1A:
undetectable
1w5uB-4og1A:
undetectable		 1w5uA-4og1A:
7.56
1w5uB-4og1A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		6 / 12 ALA A 100
ALA A  99
ALA A 154
VAL A 114
CYH A  66
LEU A  23
 None
 1.40A 1xlsA-4og1A:
undetectable		 1xlsA-4og1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		6 / 12 ALA A 100
ALA A  99
ALA A 154
VAL A 114
CYH A  66
LEU A  23
 None
 1.40A 1xlsD-4og1A:
undetectable		 1xlsD-4og1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 TRP A 103
ALA A 154
VAL A 125
 None
 0.86A 2izqC-4og1A:
undetectable
2izqD-4og1A:
undetectable		 2izqC-4og1A:
7.56
2izqD-4og1A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 9 ALA A 112
VAL A 114
GLY A  60
ILE A  40
ALA A 126
 None
 0.92A 2z0yB-4og1A:
undetectable		 2z0yB-4og1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 11 LEU A  58
VAL A 110
MET A  36
LEU A  47
PHE A  65
 None
 1.05A 3bszE-4og1A:
undetectable		 3bszE-4og1A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 SER A  59
ALA A 113
GLY A 199
HIS A  20
VAL A  57
 None
 0.89A 3f8wA-4og1A:
undetectable		 3f8wA-4og1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 121
GLY A 122
GLN A 124
VAL A 125
ILE A  40
 None
 0.83A 3h52B-4og1A:
undetectable		 3h52B-4og1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 TRP A 103
ALA A 154
VAL A 125
 None
 1.00A 3l8lA-4og1A:
undetectable
3l8lB-4og1A:
undetectable		 3l8lA-4og1A:
7.56
3l8lB-4og1A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 TRP A 103
ALA A 154
VAL A 125
 None
 0.90A 3l8lC-4og1A:
undetectable
3l8lD-4og1A:
undetectable		 3l8lC-4og1A:
7.56
3l8lD-4og1A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 9 GLY A 128
ALA A 129
ASP A 130
ILE A 111
LEU A  58
 None
 1.03A 3ogpB-4og1A:
undetectable		 3ogpB-4og1A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 GLN A  97
THR A  89
ASN A  94
 None
 0.86A 3v4tE-4og1A:
1.7		 3v4tE-4og1A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 128
GLY A 122
GLY A 121
ASP A 130
VAL A 102
 None
 0.84A 4b17A-4og1A:
undetectable		 4b17A-4og1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 CYH A  66
ALA A  99
GLY A 122
LEU A 140
ALA A 100
 None
 1.07A 4lg1C-4og1A:
undetectable		 4lg1C-4og1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 ILE A  14
VAL A  12
VAL A  10
PHE A   6
MET A   4
 None
 0.95A 4y0sA-4og1A:
undetectable		 4y0sA-4og1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 MET A  36
PHE A  37
ILE A  40
GLY A 128
MET A 153
 None
 1.04A 5byjA-4og1A:
undetectable		 5byjA-4og1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 7 VAL A  12
ILE A  14
VAL A  56
ALA A  19
 None
 0.58A 5osrA-4og1A:
undetectable		 5osrA-4og1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		3 / 3 GLY A 161
ASN A 162
ARG A 104
 None
 0.72A 5w7bD-4og1A:
undetectable		 5w7bD-4og1A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 129
VAL A  21
GLY A  44
ALA A  43
LEU A  23
 None
 1.06A 5xxiA-4og1A:
undetectable		 5xxiA-4og1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 4og1 ENOYL-COA
HYDRATASE/ISOMERASE
(Novosphingobium
aromaticivorans) 		4 / 5 HIS A  20
ALA A 113
SER A  59
GLY A  60
 None
 1.22A 5yodD-4og1A:
undetectable		 5yodD-4og1A:
17.91