SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ogc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 4 LEU A 797
PRO A  36
LEU A 800
ARG A 804
 None
 1.17A 1hrkB-4ogcA:
undetectable		 1hrkB-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 4 GLY A 841
LEU A 871
GLY A 839
ARG A 877
 None
 1.12A 1j7kA-4ogcA:
2.3		 1j7kA-4ogcA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 8 SER A1005
ASN A1002
ILE A1001
GLY A1012
 None
 0.91A 1meiA-4ogcA:
undetectable		 1meiA-4ogcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 LEU A  43
SER A  44
GLY A  15
ALA A 740
SER A 741
 None
 1.09A 1pxxC-4ogcA:
undetectable		 1pxxC-4ogcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 10 LEU A 448
SER A 287
PHE A 283
ALA A 428
ALA A 427
 None
 1.16A 1wygA-4ogcA:
undetectable		 1wygA-4ogcA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 7 ARG A 730
LEU A 721
PRO A1039
VAL A1041
 None
 1.34A 2hrcA-4ogcA:
undetectable		 2hrcA-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 4 LEU A 797
PRO A  36
LEU A 800
ARG A 804
 None
 1.24A 2hrcA-4ogcA:
undetectable		 2hrcA-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 4 LEU A 797
PRO A  36
LEU A 800
ARG A 804
 None
 1.18A 2hrcB-4ogcA:
undetectable		 2hrcB-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		3 / 3 LYS A 897
GLY A 923
PRO A 924
 None
 0.78A 2hreB-4ogcA:
undetectable		 2hreB-4ogcA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 MET A 366
LEU A 417
LEU A 420
ILE A 406
PRO A 274
 None
 1.01A 2pnjA-4ogcA:
undetectable		 2pnjA-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 4 LEU A 797
PRO A  36
LEU A 800
ARG A 804
 None
 1.15A 2pnjB-4ogcA:
undetectable		 2pnjB-4ogcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		3 / 3 LEU A 422
PRO A 423
ARG A 391
 None
 0.55A 2qd4B-4ogcA:
undetectable		 2qd4B-4ogcA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		3 / 3 LEU A 422
PRO A 423
ARG A 391
 None
 0.60A 2qd5A-4ogcA:
undetectable		 2qd5A-4ogcA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 5 ILE A1057
PHE A1006
PRO A1039
VAL A 940
 None
 1.25A 2ygnA-4ogcA:
undetectable		 2ygnA-4ogcA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 6 LEU A 482
VAL A 485
VAL A 700
VAL A 504
 None
 0.95A 2z97A-4ogcA:
undetectable		 2z97A-4ogcA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 MET A 366
ASP A 360
ILE A 390
ARG A 367
THR A 369
 None
 1.37A 3lpsA-4ogcA:
undetectable		 3lpsA-4ogcA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 5 HIS A  21
ARG A 527
ASP A 509
THR A  20
 None
 1.47A 3okxA-4ogcA:
undetectable		 3okxA-4ogcA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 5 HIS A  21
ARG A 527
ASP A 509
THR A  20
 None
 1.47A 3okxB-4ogcA:
undetectable		 3okxB-4ogcA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 ILE A 879
ILE A 886
ALA A 850
LEU A 859
LEU A 842
 None
 0.99A 3uvvA-4ogcA:
undetectable		 3uvvA-4ogcA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 5 LEU A 448
ARG A 452
PRO A 464
ALA A 428
 None
 1.23A 3vm4A-4ogcA:
undetectable		 3vm4A-4ogcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 LEU A 409
LEU A 374
LEU A 420
ILE A 405
THR A 362
 None
 1.30A 4f4dA-4ogcA:
undetectable		 4f4dA-4ogcA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 7 VAL A 810
SER A 741
LEU A 721
ASP A 732
 None
 1.08A 4hxyB-4ogcA:
undetectable		 4hxyB-4ogcA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 LEU A  43
SER A  44
GLY A  15
ALA A 740
SER A 741
 None
 0.94A 4otyA-4ogcA:
undetectable		 4otyA-4ogcA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 LEU A  43
SER A  44
GLY A  15
ALA A 740
SER A 741
 None
 0.96A 4otyB-4ogcA:
undetectable		 4otyB-4ogcA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 LEU A  43
SER A  44
GLY A  15
ALA A 740
SER A 741
 None
 0.97A 4rrwD-4ogcA:
undetectable		 4rrwD-4ogcA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 LEU A  43
SER A  44
GLY A  15
ALA A 740
SER A 741
 None
 0.97A 4rrzD-4ogcA:
undetectable		 4rrzD-4ogcA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		3 / 3 ASP A 950
ARG A 972
PRO A 853
 None
 0.90A 4wanC-4ogcA:
1.4		 4wanC-4ogcA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 6 ALA A 255
SER A 254
ASP A 396
PRO A 397
 None
 1.08A 5c6pA-4ogcA:
undetectable		 5c6pA-4ogcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 8 ARG A1023
GLU A 998
PRO A1086
GLY A1084
 None
 0.80A 5kgpA-4ogcA:
undetectable		 5kgpA-4ogcA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 8 ARG A1023
GLU A 998
PRO A1086
GLY A1084
 None
 0.76A 5kgpB-4ogcA:
undetectable		 5kgpB-4ogcA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		5 / 12 ASP A 876
GLU A 875
ALA A 873
ARG A 837
LEU A 838
 None
 1.28A 5nd2B-4ogcA:
undetectable		 5nd2B-4ogcA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 5 GLN A 281
ASP A 363
SER A 320
ARG A 367
 None
 1.00A 5w4zA-4ogcA:
undetectable		 5w4zA-4ogcA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		3 / 3 LEU A 797
VAL A 738
ASP A 739
 None
None
MN  A1206 (-4.6A)
 0.59A 5x23A-4ogcA:
undetectable		 5x23A-4ogcA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 8 SER A  44
HIS A 735
PHE A 801
LEU A 721
 None
 1.07A 5y2tB-4ogcA:
undetectable		 5y2tB-4ogcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN
(Actinomyces
naeslundii) 		4 / 6 TYR A 989
ALA A 929
ARG A 930
ASP A 958
 None
 0.67A 6hu9m-4ogcA:
undetectable
6hu9q-4ogcA:
0.5		 6hu9m-4ogcA:
19.19
6hu9q-4ogcA:
9.84