SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ogz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		5 / 12 ILE A 494
ALA A 437
ALA A 439
VAL A 468
LEU A 323
 None
 1.05A 1cbsA-4ogzA:
undetectable		 1cbsA-4ogzA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		5 / 11 LEU A 239
LEU A 119
LEU A 120
GLY A 292
LEU A 265
 None
 1.29A 1g50C-4ogzA:
undetectable		 1g50C-4ogzA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 8 ASP A 238
ARG A 270
GLY A  86
GLY A 201
 PGE  A 503 (-3.7A)
PGE  A 503 (-3.1A)
None
None
 0.76A 1jr1B-4ogzA:
5.8		 1jr1B-4ogzA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 8 ASP A 342
ASN A 128
GLY A 134
GLY A 315
 None
 0.87A 1jr1B-4ogzA:
5.8		 1jr1B-4ogzA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 6 ASN A 131
GLY A 318
ILE A 319
ILE A 355
 None
 0.83A 1n49D-4ogzA:
undetectable		 1n49D-4ogzA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 8 ASP A 228
PHE A 232
GLY A 220
ASP A 209
 None
 0.99A 1rmtC-4ogzA:
undetectable		 1rmtC-4ogzA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		5 / 12 ILE A 494
ALA A 437
ALA A 439
VAL A 468
LEU A 323
 None
 1.05A 2fr3A-4ogzA:
undetectable		 2fr3A-4ogzA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 5 LEU A  71
PRO A  72
LEU A  75
ILE A  84
 None
 0.83A 2qd4A-4ogzA:
2.7		 2qd4A-4ogzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 8 ILE A 322
GLY A 318
ARG A 308
LEU A 305
 None
 0.60A 2vctA-4ogzA:
undetectable		 2vctA-4ogzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 8 ILE A 322
GLY A 318
ARG A 308
LEU A 305
 None
 0.65A 2vctB-4ogzA:
undetectable		 2vctB-4ogzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 8 ILE A 322
GLY A 318
ARG A 308
LEU A 305
 None
 0.67A 2vctC-4ogzA:
undetectable		 2vctC-4ogzA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 7 LEU A  71
ASN A  70
GLU A 110
LEU A 112
 None
 1.07A 2w8yA-4ogzA:
undetectable		 2w8yA-4ogzA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 7 LEU A 119
ASP A 117
SER A 271
THR A  50
 None
 1.35A 3dzgB-4ogzA:
2.1		 3dzgB-4ogzA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		5 / 10 LEU A 197
ILE A 272
VAL A 237
VAL A 193
LEU A 204
 None
 1.20A 3ogpB-4ogzA:
undetectable		 3ogpB-4ogzA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		5 / 12 CYH A 490
HIS A 370
LEU A 403
VAL A 468
LEU A 323
 None
 1.42A 4o8fB-4ogzA:
undetectable		 4o8fB-4ogzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		5 / 12 CYH A 490
LEU A 403
VAL A 468
MET A 376
LEU A 323
 None
 1.49A 4o8fB-4ogzA:
undetectable		 4o8fB-4ogzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		3 / 3 ASP A 243
TYR A 207
TRP A 279
 None
 1.07A 4p7nA-4ogzA:
4.3		 4p7nA-4ogzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		3 / 3 ALA A 415
TRP A 427
VAL A 428
 None
 0.37A 4w9nC-4ogzA:
undetectable		 4w9nC-4ogzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 5 LEU A 485
CYH A 490
LEU A 373
ASP A 425
 None
 1.49A 5mafA-4ogzA:
2.2		 5mafA-4ogzA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 6 TYR A  55
LEU A 204
PHE A 202
LEU A  53
 None
None
None
PGE  A 503 ( 3.7A)
 1.18A 5tl8A-4ogzA:
undetectable		 5tl8A-4ogzA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		4 / 8 GLY A 300
TRP A 374
ASP A 340
ASP A 243
 None
 1.04A 5vlmB-4ogzA:
undetectable		 5vlmB-4ogzA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		3 / 3 ASN A 339
VAL A 273
HIS A 294
 None
 0.86A 6a5yD-4ogzA:
undetectable		 6a5yD-4ogzA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ogz PUTATIVE
ALPHA-GALACTOSIDASE/
MELIBIASE
(Bacteroides
fragilis) 		3 / 3 LEU A 265
ASN A 163
LEU A 295
 None
 0.71A 6exiD-4ogzA:
undetectable		 6exiD-4ogzA:
10.32