SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		7 / 12 ALA A  82
SER A  83
SER A 130
LYS A 220
SER A 221
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.1A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.50A 1ghmA-4oh0A:
17.1		 1ghmA-4oh0A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 12 MET A 127
ILE A 176
LEU A 217
VAL A 209
VAL A 185
 KCX  A  86 ( 3.6A)
None
None
None
None
 1.19A 1hrkA-4oh0A:
undetectable		 1hrkA-4oh0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		4 / 4 LYS A 273
LEU A  47
LEU A 266
SER A 267
 None
 1.47A 1tt6A-4oh0A:
undetectable		 1tt6A-4oh0A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 11 PHE A  57
THR A  59
GLY A 275
VAL A 238
VAL A 246
 None
 1.29A 2a1nA-4oh0A:
undetectable		 2a1nA-4oh0A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 10 PHE A  57
THR A  59
GLY A 275
VAL A 238
VAL A 246
 None
 1.28A 2cp4A-4oh0A:
undetectable		 2cp4A-4oh0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 12 MET A 127
ILE A 176
LEU A 217
VAL A 209
VAL A 185
 KCX  A  86 ( 3.6A)
None
None
None
None
 1.20A 2hrcB-4oh0A:
undetectable		 2hrcB-4oh0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 10 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 1.02A 3lxiA-4oh0A:
undetectable		 3lxiA-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 11 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 0.96A 3lxiB-4oh0A:
undetectable		 3lxiB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 9 LEU A 193
PHE A 195
LEU A 151
ILE A  92
ALA A  90
 None
None
None
None
KCX  A  86 ( 3.3A)
 0.88A 3mdvA-4oh0A:
undetectable		 3mdvA-4oh0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 12 ALA A  82
SER A  83
SER A 130
LYS A 220
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.46A 3sh8A-4oh0A:
18.5		 3sh8A-4oh0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 12 ALA A  82
SER A  83
SER A 130
LYS A 220
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.47A 3sh8B-4oh0A:
18.7		 3sh8B-4oh0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 9 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 1.04A 4c9kB-4oh0A:
undetectable		 4c9kB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 10 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 1.05A 4c9nB-4oh0A:
undetectable		 4c9nB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 12 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 1.06A 4c9oA-4oh0A:
undetectable		 4c9oA-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 12 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 1.07A 4c9oB-4oh0A:
undetectable		 4c9oB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 9 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 1.05A 4c9pA-4oh0A:
undetectable		 4c9pA-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 10 THR A  59
LEU A 274
GLY A 275
VAL A 238
VAL A 246
 None
 1.03A 4c9pB-4oh0A:
undetectable		 4c9pB-4oh0A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 12 ALA A  82
SER A  83
SER A 130
LYS A 220
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.46A 4n9kA-4oh0A:
18.5		 4n9kA-4oh0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 12 ALA A  82
SER A  83
SER A 130
LYS A 220
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.46A 4n9kB-4oh0A:
18.5		 4n9kB-4oh0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 9 PHE A  57
THR A  59
GLY A 275
VAL A 238
VAL A 246
 None
 1.30A 5cp4A-4oh0A:
undetectable		 5cp4A-4oh0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 12 ALA A  82
SER A  83
SER A 130
LYS A 220
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.45A 5ghyA-4oh0A:
18.6		 5ghyA-4oh0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 12 ALA A  82
SER A  83
SER A 130
LYS A 220
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.44A 5ghyB-4oh0A:
18.7		 5ghyB-4oh0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 11 ALA A  82
SER A  83
SER A 130
LYS A 220
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.44A 5ghzA-4oh0A:
18.5		 5ghzA-4oh0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 10 ALA A  82
SER A  83
SER A 130
LYS A 220
GLY A 222
ARG A 263
 None
KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
CL  A 301 (-3.7A)
 0.46A 5ghzB-4oh0A:
18.5		 5ghzB-4oh0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 9 LEU A 193
ILE A 142
LEU A 138
PHE A 184
ILE A  87
 None
None
None
None
KCX  A  86 ( 4.4A)
 0.93A 5vkqC-4oh0A:
undetectable
5vkqD-4oh0A:
undetectable		 5vkqC-4oh0A:
10.11
5vkqD-4oh0A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		5 / 12 SER A  83
SER A 130
LYS A 220
GLY A 222
GLY A 224
 KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
None
 0.58A 6b68D-4oh0A:
17.8		 6b68D-4oh0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		6 / 12 SER A  83
SER A 130
ARG A 263
LYS A 220
GLY A 222
GLY A 224
 KCX  A  86 ( 2.6A)
KCX  A  86 ( 3.3A)
CL  A 301 (-3.7A)
CL  A 301 ( 4.4A)
CL  A 301 (-3.6A)
None
 0.91A 6b6aB-4oh0A:
17.7		 6b6aB-4oh0A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4oh0 BETA-LACTAMASE
OXA-58
(Acinetobacter
baumannii) 		3 / 3 ASP A 187
LEU A 193
ARG A 153
 None
 0.80A 7dfrA-4oh0A:
undetectable		 7dfrA-4oh0A:
22.10