SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 LEU A 162
GLY A 182
GLY A 183
ALA A 161
LEU A 191
 None
 0.98A 1bx4A-4oh1A:
4.4		 1bx4A-4oh1A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		4 / 8 PHE A 333
PHE A 129
ALA A 332
ILE A 344
 None
 1.15A 1pnlA-4oh1A:
undetectable
1pnlB-4oh1A:
undetectable		 1pnlA-4oh1A:
20.41
1pnlB-4oh1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 GLY A 247
ASP A 204
VAL A 202
GLY A 183
ILE A 178
 None
 0.90A 2f81A-4oh1A:
undetectable		 2f81A-4oh1A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 GLY A 247
ASP A 204
VAL A 202
GLY A 183
ILE A 178
 None
 0.91A 2f81B-4oh1A:
undetectable		 2f81B-4oh1A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 GLY A 247
ASP A 204
VAL A 202
GLY A 183
ILE A 178
 None
 0.97A 2f8gA-4oh1A:
undetectable		 2f8gA-4oh1A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 3 SER A 224
GLU A 246
ASP A 204
 None
 0.79A 2zthA-4oh1A:
4.3		 2zthA-4oh1A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		4 / 7 VAL A 160
HIS A  73
LEU A 184
ILE A 298
 None
ZN  A 401 (-3.5A)
None
None
 0.72A 3avpA-4oh1A:
undetectable		 3avpA-4oh1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 3 SER A 224
GLU A 246
ASP A 204
 None
 0.87A 3bwmA-4oh1A:
3.9		 3bwmA-4oh1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 3 SER A 224
GLU A 246
ASP A 204
 None
 0.83A 3bwyA-4oh1A:
3.9		 3bwyA-4oh1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 GLY A 247
ASP A 204
VAL A 202
GLY A 183
ILE A 178
 None
 0.93A 3d1zB-4oh1A:
undetectable		 3d1zB-4oh1A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 GLY A 247
ASP A 204
VAL A 202
GLY A 183
ILE A 178
 None
 0.95A 3d20B-4oh1A:
undetectable		 3d20B-4oh1A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 9 GLY A 247
ASP A 204
VAL A 202
GLY A 183
ILE A 178
 None
 0.99A 3oxvC-4oh1A:
undetectable		 3oxvC-4oh1A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 GLY A 247
ASP A 204
VAL A 202
GLY A 183
ILE A 178
 None
 0.92A 3pwmB-4oh1A:
undetectable		 3pwmB-4oh1A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 HIS A  73
GLY A  72
GLY A  46
SER A  47
SER A 164
 ZN  A 401 (-3.5A)
None
OCS  A  45 ( 2.4A)
OCS  A  45 ( 3.0A)
None
 1.20A 3sueD-4oh1A:
undetectable		 3sueD-4oh1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 10 GLY A 182
ASP A 204
GLY A 180
MET A 186
VAL A 189
 None
 1.30A 4c5lC-4oh1A:
2.0		 4c5lC-4oh1A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 10 GLY A 182
ASP A 204
GLY A 180
MET A 186
VAL A 189
 None
 1.28A 4c5lD-4oh1A:
6.4		 4c5lD-4oh1A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		4 / 8 GLY A 182
GLY A 180
MET A 186
VAL A 189
 None
 0.89A 4c5nC-4oh1A:
7.0		 4c5nC-4oh1A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 9 GLY A  72
GLY A 128
GLU A  74
PHE A 333
ILE A 346
 None
None
ZN  A 401 (-3.1A)
None
None
 1.24A 4fgjA-4oh1A:
undetectable
4fgjB-4oh1A:
undetectable		 4fgjA-4oh1A:
20.56
4fgjB-4oh1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 4 SER A  43
GLY A 185
GLU A 246
 None
 0.61A 4juoA-4oh1A:
undetectable
4juoC-4oh1A:
2.6		 4juoA-4oh1A:
22.03
4juoC-4oh1A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 3 VAL A  98
GLY A  77
LYS A  96
 None
 0.64A 4k50A-4oh1A:
undetectable		 4k50A-4oh1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 3 VAL A  98
GLY A  77
LYS A  96
 None
 0.69A 4k50E-4oh1A:
undetectable		 4k50E-4oh1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 3 VAL A  98
GLY A  77
LYS A  96
 None
 0.68A 4k50I-4oh1A:
undetectable		 4k50I-4oh1A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 9 ASP A 219
VAL A 176
GLY A 196
VAL A 189
ILE A 200
 None
 1.07A 4ll3B-4oh1A:
undetectable		 4ll3B-4oh1A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 LEU A 162
GLY A 182
GLY A 183
ALA A 161
GLY A  46
 None
None
None
None
OCS  A  45 ( 2.4A)
 0.96A 4n09B-4oh1A:
5.6		 4n09B-4oh1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		6 / 12 LEU A 162
GLY A 182
GLY A 183
ALA A 161
LEU A 191
GLY A  46
 None
None
None
None
None
OCS  A  45 ( 2.4A)
 1.19A 4n09C-4oh1A:
4.9		 4n09C-4oh1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 LEU A 162
GLY A 182
GLY A 183
ALA A 161
GLY A  46
 None
None
None
None
OCS  A  45 ( 2.4A)
 0.97A 4n09D-4oh1A:
5.6		 4n09D-4oh1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 11 GLY A 247
ASP A 204
VAL A 202
GLY A 183
ILE A 178
 None
 0.98A 4njvB-4oh1A:
undetectable		 4njvB-4oh1A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 ILE A 178
VAL A 176
LEU A 245
ALA A 195
LEU A 191
 None
 1.07A 4o1zB-4oh1A:
undetectable		 4o1zB-4oh1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 3 SER A 224
GLU A 246
ASP A 204
 None
 0.82A 4xudA-4oh1A:
3.8		 4xudA-4oh1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 ALA A 153
LEU A 336
GLY A  54
HIS A  73
PHE A 129
 None
None
None
ZN  A 401 (-3.5A)
None
 1.16A 5fsaA-4oh1A:
undetectable		 5fsaA-4oh1A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		3 / 3 GLY A 106
CYH A 111
CYH A 108
 ZN  A 402 ( 4.8A)
ZN  A 402 (-2.4A)
ZN  A 402 (-2.3A)
 0.97A 5inzB-4oh1A:
undetectable		 5inzB-4oh1A:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 SER A 224
PHE A 270
ILE A 205
ALA A 213
GLY A 183
 None
 1.11A 5veuA-4oh1A:
undetectable		 5veuA-4oh1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 LEU A 245
ASP A 204
VAL A 202
VAL A 176
ILE A 178
 None
 1.11A 6dgxB-4oh1A:
undetectable		 6dgxB-4oh1A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 4oh1 L-IDITOL
2-DEHYDROGENASE
([Clostridium]
scindens) 		5 / 12 ASP A 219
VAL A 176
GLY A 196
VAL A 189
ILE A 200
 None
 0.94A 6dh6A-4oh1A:
undetectable		 6dh6A-4oh1A:
12.00