SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oh7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 THR A 211
PRO A 187
THR A 186
 None
 0.85A 1a7yB-4oh7A:
undetectable		 1a7yB-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		4 / 5 ASP A 142
LEU A  25
ALA A 174
LEU A 171
 None
 1.06A 1nh8A-4oh7A:
undetectable		 1nh8A-4oh7A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 ASN A 166
SER A  63
ASP A 142
GLN A 138
VAL A 172
 None
 1.45A 1qu3A-4oh7A:
undetectable		 1qu3A-4oh7A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 THR A 186
THR A 211
PRO A 187
 None
 0.86A 1unjL-4oh7A:
undetectable		 1unjL-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 THR A 211
PRO A 187
THR A 186
 None
 0.83A 1unjR-4oh7A:
undetectable		 1unjR-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 THR A 186
THR A 211
PRO A 187
 None
 0.84A 1unjR-4oh7A:
undetectable		 1unjR-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 THR A 211
PRO A 187
THR A 186
 None
 0.85A 1unjX-4oh7A:
undetectable		 1unjX-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 THR A 186
THR A 211
PRO A 187
 None
 0.84A 1unjX-4oh7A:
undetectable		 1unjX-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 THR A 211
PRO A 187
THR A 186
 None
 0.86A 1unmF-4oh7A:
undetectable		 1unmF-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 THR A 186
THR A 211
PRO A 187
 None
 0.85A 1unmF-4oh7A:
undetectable		 1unmF-4oh7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		3 / 3 LYS A  29
ASP A 142
CYH A 222
 None
 1.19A 2br4F-4oh7A:
3.8		 2br4F-4oh7A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 ILE A 153
ALA A 296
LEU A  25
LEU A  13
PHE A 180
 None
 1.14A 2h77A-4oh7A:
undetectable		 2h77A-4oh7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		4 / 8 PHE A 287
SER A 284
ALA A 268
LEU A 266
 None
 0.98A 2o01A-4oh7A:
undetectable		 2o01A-4oh7A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		4 / 7 LEU A 171
ALA A 174
PHE A 178
PHE A 180
 None
 0.54A 2vcvL-4oh7A:
undetectable		 2vcvL-4oh7A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 THR A 227
LEU A 266
PHE A 262
VAL A 248
THR A 145
 None
 1.14A 3czhB-4oh7A:
undetectable		 3czhB-4oh7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		4 / 4 ARG A  59
ASP A 133
GLY A 164
THR A 227
 None
 1.50A 3k4vB-4oh7A:
undetectable		 3k4vB-4oh7A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		5 / 10 PHE A  64
ARG A  31
ALA A 302
LEU A 301
GLY A  67
 None
 1.37A 4fe1A-4oh7A:
undetectable
4fe1J-4oh7A:
undetectable		 4fe1A-4oh7A:
19.56
4fe1J-4oh7A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		4 / 4 LEU A 266
ILE A 279
HIS A 264
VAL A 286
 None
 0.94A 4xyzA-4oh7A:
undetectable		 4xyzA-4oh7A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 4oh7 ORNITHINE
CARBAMOYLTRANSFERASE
(Brucella
melitensis) 		4 / 4 VAL A 172
ALA A 176
PHE A 180
PHE A 178
 None
 1.46A 6cbdA-4oh7A:
5.9		 6cbdA-4oh7A:
17.69