SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ohn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 LEU A 208
ALA A 152
ALA A 150
VAL A 130
LEU A 189
 None
None
None
None
ACT  A 302 ( 4.9A)
 1.34A 1hbpA-4ohnA:
undetectable		 1hbpA-4ohnA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 SER A 107
VAL A 231
PHE A  49
VAL A 202
 HIS  A 301 (-2.2A)
None
HIS  A 301 (-3.4A)
None
 1.13A 1o86A-4ohnA:
undetectable		 1o86A-4ohnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASN A  81
VAL A  80
GLY A  44
ILE A 102
ILE A  41
 None
 0.97A 2q64A-4ohnA:
undetectable		 2q64A-4ohnA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.20A 3jq7B-4ohnA:
undetectable		 3jq7B-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.22A 3jqaA-4ohnA:
undetectable		 3jqaA-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.22A 3jqaB-4ohnA:
undetectable		 3jqaB-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.20A 3jqaC-4ohnA:
undetectable		 3jqaC-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 ARG A 112
PHE A 229
ASP A  65
TYR A 122
 HIS  A 301 ( 3.0A)
HIS  A 301 ( 4.8A)
None
None
 1.20A 3jqaD-4ohnA:
undetectable		 3jqaD-4ohnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A  97
GLY A  44
ILE A  85
ALA A  92
ILE A 102
 None
 1.21A 3n3iA-4ohnA:
undetectable		 3n3iA-4ohnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLY A  97
GLY A  44
ILE A  85
VAL A 116
ALA A  92
 None
None
None
ACT  A 303 ( 4.3A)
None
 1.08A 3n3iA-4ohnA:
undetectable		 3n3iA-4ohnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A  66
VAL A  80
ILE A  99
LEU A  94
VAL A 116
 None
None
None
None
ACT  A 303 ( 4.3A)
 1.20A 3w67C-4ohnA:
undetectable		 3w67C-4ohnA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB504_1
(HEMOLYTIC LECTIN
CEL-III)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLU A  74
GLY A  77
TYR A  76
GLN A  36
 None
 1.45A 3w9tB-4ohnA:
undetectable		 3w9tB-4ohnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 1.06A 4mm5A-4ohnA:
undetectable		 4mm5A-4ohnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 1.06A 4mm9A-4ohnA:
undetectable		 4mm9A-4ohnA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 1.03A 4mmbA-4ohnA:
undetectable		 4mmbA-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 0.99A 4mmdB-4ohnA:
undetectable		 4mmdB-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 0.98A 4mmeA-4ohnA:
undetectable		 4mmeA-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 0.97A 4mmeB-4ohnA:
undetectable		 4mmeB-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 1.00A 4mmfA-4ohnA:
undetectable		 4mmfA-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A  62
TYR A  61
GLY A  44
SER A  47
GLY A  53
 None
 1.03A 4mmfB-4ohnA:
undetectable		 4mmfB-4ohnA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLU A 175
LYS A 168
ASN A 173
 None
 1.09A 4y1dA-4ohnA:
undetectable
4y1dD-4ohnA:
undetectable		 4y1dA-4ohnA:
22.27
4y1dD-4ohnA:
12.90