SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.23A 1c9sA-4ohtA:
undetectable
1c9sK-4ohtA:
undetectable		 1c9sA-4ohtA:
9.89
1c9sK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.22A 1c9sA-4ohtA:
undetectable
1c9sB-4ohtA:
undetectable		 1c9sA-4ohtA:
9.89
1c9sB-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 1c9sB-4ohtA:
undetectable
1c9sC-4ohtA:
undetectable		 1c9sB-4ohtA:
9.89
1c9sC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 1c9sC-4ohtA:
undetectable
1c9sD-4ohtA:
undetectable		 1c9sC-4ohtA:
9.89
1c9sD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 1c9sD-4ohtA:
undetectable
1c9sE-4ohtA:
undetectable		 1c9sD-4ohtA:
9.89
1c9sE-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 1c9sE-4ohtA:
undetectable
1c9sF-4ohtA:
undetectable		 1c9sE-4ohtA:
9.89
1c9sF-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 1c9sF-4ohtA:
undetectable
1c9sG-4ohtA:
undetectable		 1c9sF-4ohtA:
9.89
1c9sG-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 1c9sG-4ohtA:
undetectable
1c9sH-4ohtA:
undetectable		 1c9sG-4ohtA:
9.89
1c9sH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 1c9sH-4ohtA:
undetectable
1c9sI-4ohtA:
undetectable		 1c9sH-4ohtA:
9.89
1c9sI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 1c9sJ-4ohtA:
undetectable
1c9sK-4ohtA:
undetectable		 1c9sJ-4ohtA:
9.89
1c9sK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 1c9sL-4ohtA:
undetectable
1c9sM-4ohtA:
undetectable		 1c9sL-4ohtA:
9.89
1c9sM-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.27A 1c9sM-4ohtA:
undetectable
1c9sN-4ohtA:
undetectable		 1c9sM-4ohtA:
9.89
1c9sN-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.23A 1c9sS-4ohtA:
undetectable
1c9sT-4ohtA:
undetectable		 1c9sS-4ohtA:
9.89
1c9sT-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 6 TRP A 418
GLY A 260
ASN A 132
PRO A 364
 None
 1.19A 1dedA-4ohtA:
undetectable		 1dedA-4ohtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.25A 1gtfA-4ohtA:
undetectable
1gtfK-4ohtA:
undetectable		 1gtfA-4ohtA:
9.89
1gtfK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 1gtfA-4ohtA:
undetectable
1gtfB-4ohtA:
undetectable		 1gtfA-4ohtA:
9.89
1gtfB-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.22A 1gtfB-4ohtA:
undetectable
1gtfC-4ohtA:
undetectable		 1gtfB-4ohtA:
9.89
1gtfC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 1gtfC-4ohtA:
undetectable
1gtfD-4ohtA:
undetectable		 1gtfC-4ohtA:
9.89
1gtfD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.28A 1gtfE-4ohtA:
undetectable
1gtfF-4ohtA:
undetectable		 1gtfE-4ohtA:
9.89
1gtfF-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 1gtfF-4ohtA:
undetectable
1gtfG-4ohtA:
undetectable		 1gtfF-4ohtA:
9.89
1gtfG-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 1gtfG-4ohtA:
undetectable
1gtfH-4ohtA:
undetectable		 1gtfG-4ohtA:
9.89
1gtfH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 1gtfH-4ohtA:
undetectable
1gtfI-4ohtA:
undetectable		 1gtfH-4ohtA:
9.89
1gtfI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 1gtfI-4ohtA:
undetectable
1gtfJ-4ohtA:
undetectable		 1gtfI-4ohtA:
9.89
1gtfJ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.29A 1gtfP-4ohtA:
undetectable
1gtfQ-4ohtA:
undetectable		 1gtfP-4ohtA:
9.89
1gtfQ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.29A 1gtfT-4ohtA:
undetectable
1gtfU-4ohtA:
undetectable		 1gtfT-4ohtA:
9.89
1gtfU-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 1gtfU-4ohtA:
undetectable
1gtfV-4ohtA:
undetectable		 1gtfU-4ohtA:
9.89
1gtfV-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.22A 1gtnB-4ohtA:
undetectable
1gtnC-4ohtA:
undetectable		 1gtnB-4ohtA:
9.89
1gtnC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 1gtnG-4ohtA:
undetectable
1gtnH-4ohtA:
undetectable		 1gtnG-4ohtA:
9.89
1gtnH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 1gtnH-4ohtA:
undetectable
1gtnI-4ohtA:
undetectable		 1gtnH-4ohtA:
9.89
1gtnI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.33A 1gtnN-4ohtA:
undetectable
1gtnO-4ohtA:
undetectable		 1gtnN-4ohtA:
9.89
1gtnO-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 6 ILE A 186
LYS A 155
ALA A 127
MET A 152
 None
NAP  A 501 (-2.7A)
None
None
 1.17A 1hk2A-4ohtA:
undetectable		 1hk2A-4ohtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 THR A   5
ASP A  73
GLY A  75
ALA A 312
GLN A 309
 None
 1.28A 1oltA-4ohtA:
undetectable		 1oltA-4ohtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.20A 1utdA-4ohtA:
undetectable
1utdB-4ohtA:
undetectable		 1utdA-4ohtA:
9.89
1utdB-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 1utdC-4ohtA:
undetectable
1utdD-4ohtA:
undetectable		 1utdC-4ohtA:
9.89
1utdD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.22A 1utdD-4ohtA:
undetectable
1utdE-4ohtA:
undetectable		 1utdD-4ohtA:
9.89
1utdE-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.23A 1utdG-4ohtA:
undetectable
1utdH-4ohtA:
undetectable		 1utdG-4ohtA:
9.89
1utdH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 1utdA-4ohtA:
undetectable
1utdK-4ohtA:
undetectable		 1utdA-4ohtA:
9.89
1utdK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.25A 1utdM-4ohtA:
undetectable
1utdN-4ohtA:
undetectable		 1utdM-4ohtA:
9.89
1utdN-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 1utdN-4ohtA:
undetectable
1utdO-4ohtA:
undetectable		 1utdN-4ohtA:
9.89
1utdO-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 PHE A 167
ALA A 127
ALA A  32
GLY A 149
GLY A 123
 None
 1.08A 2igtA-4ohtA:
4.6		 2igtA-4ohtA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 PHE A 167
ALA A 127
ALA A  32
GLY A 149
GLY A 123
 None
 1.08A 2igtB-4ohtA:
4.6		 2igtB-4ohtA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 6 SER A 384
SER A 432
LEU A 388
GLY A 387
 None
 0.88A 2j2pA-4ohtA:
undetectable
2j2pC-4ohtA:
undetectable		 2j2pA-4ohtA:
20.22
2j2pC-4ohtA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 6 SER A 384
SER A 432
LEU A 388
GLY A 387
 None
 0.87A 2j2pD-4ohtA:
undetectable
2j2pF-4ohtA:
undetectable		 2j2pD-4ohtA:
20.22
2j2pF-4ohtA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 GLN A 137
PHE A 426
TRP A 418
GLY A 231
 None
 1.39A 2qmzA-4ohtA:
3.1
2qmzB-4ohtA:
3.2		 2qmzA-4ohtA:
19.57
2qmzB-4ohtA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 6 ILE A 356
ARG A 268
LEU A 350
ASP A 233
 None
 1.06A 2rlfA-4ohtA:
undetectable
2rlfD-4ohtA:
undetectable		 2rlfA-4ohtA:
7.93
2rlfD-4ohtA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		3 / 3 TYR A 386
GLU A 360
ASN A 132
 None
 1.03A 2y7hC-4ohtA:
undetectable		 2y7hC-4ohtA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		3 / 3 TYR A 357
VAL A 380
THR A 351
 None
 0.84A 2ygnA-4ohtA:
undetectable		 2ygnA-4ohtA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 4 LEU A  35
ASP A 197
VAL A  28
THR A 182
 None
 1.26A 3cyxB-4ohtA:
undetectable		 3cyxB-4ohtA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 ILE A  91
THR A 419
PHE A 133
TYR A 136
 None
 1.34A 3em0A-4ohtA:
undetectable		 3em0A-4ohtA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 SER A 445
GLY A 427
GLY A 435
LEU A 441
GLN A 137
 None
 1.02A 3fzgA-4ohtA:
4.0		 3fzgA-4ohtA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 235
GLY A 410
VAL A 380
ASP A 383
ASP A 234
 None
 0.98A 3m6vA-4ohtA:
2.7		 3m6vA-4ohtA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 235
GLY A 410
VAL A 380
ASP A 383
ASP A 234
 None
 0.98A 3m6vB-4ohtA:
3.2		 3m6vB-4ohtA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 LEU A 228
VAL A 203
ALA A 219
GLU A 217
ALA A 213
 None
 1.11A 3mdvA-4ohtA:
undetectable		 3mdvA-4ohtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 GLY A 232
ASP A 234
GLN A 261
MET A  74
 None
 1.34A 3qx3B-4ohtA:
undetectable		 3qx3B-4ohtA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 6 PRO A 295
TYR A 257
THR A 301
THR A 300
 None
 0.92A 3tneA-4ohtA:
undetectable		 3tneA-4ohtA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		3 / 3 GLN A 120
THR A 122
ASN A 448
 None
 0.86A 3v4tE-4ohtA:
0.3		 3v4tE-4ohtA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 363
ALA A 259
ASN A 258
ILE A 361
VAL A 314
 None
 1.13A 4azwA-4ohtA:
5.1		 4azwA-4ohtA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 7 HIS A 337
ILE A 335
PRO A 304
HIS A 340
 None
 1.17A 4g5jA-4ohtA:
undetectable		 4g5jA-4ohtA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 8 SER A 420
LEU A 421
TYR A 136
PRO A 425
 None
 1.21A 4j7uD-4ohtA:
4.9		 4j7uD-4ohtA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		3 / 3 ARG A  63
ASP A  90
ASP A  97
 None
 0.83A 4kicB-4ohtA:
4.3		 4kicB-4ohtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 ILE A 368
ARG A 255
ASP A 233
VAL A 371
 None
 1.19A 4nkxC-4ohtA:
undetectable		 4nkxC-4ohtA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 ILE A 368
ARG A 255
ASP A 233
VAL A 371
 None
 1.17A 4nkxD-4ohtA:
undetectable		 4nkxD-4ohtA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 356
LEU A 350
SER A 265
ILE A 361
ASN A 132
 None
 1.09A 4o1eA-4ohtA:
undetectable		 4o1eA-4ohtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 356
LEU A 350
SER A 265
ILE A 361
ASN A 132
 None
 1.12A 4o1eB-4ohtA:
undetectable		 4o1eB-4ohtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 GLY A 232
TYR A 358
SER A 384
GLU A 360
 None
 1.34A 4xueA-4ohtA:
4.9		 4xueA-4ohtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 6 SER A 439
GLU A 440
GLY A 389
GLY A 428
 None
 0.89A 5cdnA-4ohtA:
undetectable
5cdnB-4ohtA:
undetectable		 5cdnA-4ohtA:
22.20
5cdnB-4ohtA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5eeuA-4ohtA:
undetectable
5eeuB-4ohtA:
undetectable		 5eeuA-4ohtA:
9.89
5eeuB-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5eeuB-4ohtA:
undetectable
5eeuC-4ohtA:
undetectable		 5eeuB-4ohtA:
9.89
5eeuC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eeuC-4ohtA:
undetectable
5eeuD-4ohtA:
undetectable		 5eeuC-4ohtA:
9.89
5eeuD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eeuD-4ohtA:
undetectable
5eeuE-4ohtA:
undetectable		 5eeuD-4ohtA:
9.89
5eeuE-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eeuE-4ohtA:
undetectable
5eeuF-4ohtA:
undetectable		 5eeuE-4ohtA:
9.89
5eeuF-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5eeuG-4ohtA:
undetectable
5eeuH-4ohtA:
undetectable		 5eeuG-4ohtA:
9.89
5eeuH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eeuH-4ohtA:
undetectable
5eeuI-4ohtA:
undetectable		 5eeuH-4ohtA:
9.89
5eeuI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5eeuJ-4ohtA:
undetectable
5eeuK-4ohtA:
undetectable		 5eeuJ-4ohtA:
9.89
5eeuK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5eeuA-4ohtA:
undetectable
5eeuK-4ohtA:
undetectable		 5eeuA-4ohtA:
9.89
5eeuK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5eeuN-4ohtA:
undetectable
5eeuO-4ohtA:
undetectable		 5eeuN-4ohtA:
9.89
5eeuO-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eeuP-4ohtA:
undetectable
5eeuQ-4ohtA:
undetectable		 5eeuP-4ohtA:
9.89
5eeuQ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eeuR-4ohtA:
undetectable
5eeuS-4ohtA:
undetectable		 5eeuR-4ohtA:
9.89
5eeuS-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5eeuS-4ohtA:
undetectable
5eeuT-4ohtA:
undetectable		 5eeuS-4ohtA:
9.89
5eeuT-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eeuT-4ohtA:
undetectable
5eeuU-4ohtA:
undetectable		 5eeuT-4ohtA:
9.89
5eeuU-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5eeuU-4ohtA:
undetectable
5eeuV-4ohtA:
undetectable		 5eeuU-4ohtA:
9.89
5eeuV-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5eevB-4ohtA:
undetectable
5eevC-4ohtA:
undetectable		 5eevB-4ohtA:
9.89
5eevC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eevC-4ohtA:
undetectable
5eevD-4ohtA:
undetectable		 5eevC-4ohtA:
9.89
5eevD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eevD-4ohtA:
undetectable
5eevE-4ohtA:
undetectable		 5eevD-4ohtA:
9.89
5eevE-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eevE-4ohtA:
undetectable
5eevF-4ohtA:
undetectable		 5eevE-4ohtA:
9.89
5eevF-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5eevG-4ohtA:
undetectable
5eevH-4ohtA:
undetectable		 5eevG-4ohtA:
9.89
5eevH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eevH-4ohtA:
undetectable
5eevI-4ohtA:
undetectable		 5eevH-4ohtA:
9.89
5eevI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5eevJ-4ohtA:
undetectable
5eevK-4ohtA:
undetectable		 5eevJ-4ohtA:
9.89
5eevK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5eevA-4ohtA:
undetectable
5eevK-4ohtA:
undetectable		 5eevA-4ohtA:
9.89
5eevK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5eevN-4ohtA:
undetectable
5eevO-4ohtA:
undetectable		 5eevN-4ohtA:
9.89
5eevO-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eevP-4ohtA:
undetectable
5eevQ-4ohtA:
undetectable		 5eevP-4ohtA:
9.89
5eevQ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eevR-4ohtA:
undetectable
5eevS-4ohtA:
undetectable		 5eevR-4ohtA:
9.89
5eevS-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5eevS-4ohtA:
undetectable
5eevT-4ohtA:
undetectable		 5eevS-4ohtA:
9.89
5eevT-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eevT-4ohtA:
undetectable
5eevU-4ohtA:
undetectable		 5eevT-4ohtA:
9.89
5eevU-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5eevU-4ohtA:
undetectable
5eevV-4ohtA:
undetectable		 5eevU-4ohtA:
9.89
5eevV-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5eewB-4ohtA:
undetectable
5eewC-4ohtA:
undetectable		 5eewB-4ohtA:
9.89
5eewC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eewC-4ohtA:
undetectable
5eewD-4ohtA:
undetectable		 5eewC-4ohtA:
9.89
5eewD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eewD-4ohtA:
undetectable
5eewE-4ohtA:
undetectable		 5eewD-4ohtA:
9.89
5eewE-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eewE-4ohtA:
undetectable
5eewF-4ohtA:
undetectable		 5eewE-4ohtA:
9.89
5eewF-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5eewG-4ohtA:
undetectable
5eewH-4ohtA:
undetectable		 5eewG-4ohtA:
9.89
5eewH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eewH-4ohtA:
undetectable
5eewI-4ohtA:
undetectable		 5eewH-4ohtA:
9.89
5eewI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5eewJ-4ohtA:
undetectable
5eewK-4ohtA:
undetectable		 5eewJ-4ohtA:
9.89
5eewK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5eewA-4ohtA:
undetectable
5eewK-4ohtA:
undetectable		 5eewA-4ohtA:
9.89
5eewK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5eewN-4ohtA:
undetectable
5eewO-4ohtA:
undetectable		 5eewN-4ohtA:
9.89
5eewO-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eewP-4ohtA:
undetectable
5eewQ-4ohtA:
undetectable		 5eewP-4ohtA:
9.89
5eewQ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eewR-4ohtA:
undetectable
5eewS-4ohtA:
undetectable		 5eewR-4ohtA:
9.89
5eewS-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5eewS-4ohtA:
undetectable
5eewT-4ohtA:
undetectable		 5eewS-4ohtA:
9.89
5eewT-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eewT-4ohtA:
undetectable
5eewU-4ohtA:
undetectable		 5eewT-4ohtA:
9.89
5eewU-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5eewU-4ohtA:
undetectable
5eewV-4ohtA:
undetectable		 5eewU-4ohtA:
9.89
5eewV-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5eexB-4ohtA:
undetectable
5eexC-4ohtA:
undetectable		 5eexB-4ohtA:
9.89
5eexC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eexC-4ohtA:
undetectable
5eexD-4ohtA:
undetectable		 5eexC-4ohtA:
9.89
5eexD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eexD-4ohtA:
undetectable
5eexE-4ohtA:
undetectable		 5eexD-4ohtA:
9.89
5eexE-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eexE-4ohtA:
undetectable
5eexF-4ohtA:
undetectable		 5eexE-4ohtA:
9.89
5eexF-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5eexG-4ohtA:
undetectable
5eexH-4ohtA:
undetectable		 5eexG-4ohtA:
9.89
5eexH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eexH-4ohtA:
undetectable
5eexI-4ohtA:
undetectable		 5eexH-4ohtA:
9.89
5eexI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eexI-4ohtA:
undetectable
5eexJ-4ohtA:
undetectable		 5eexI-4ohtA:
9.89
5eexJ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5eexJ-4ohtA:
undetectable
5eexK-4ohtA:
undetectable		 5eexJ-4ohtA:
9.89
5eexK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5eexA-4ohtA:
undetectable
5eexK-4ohtA:
undetectable		 5eexA-4ohtA:
9.89
5eexK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5eexN-4ohtA:
undetectable
5eexO-4ohtA:
undetectable		 5eexN-4ohtA:
9.89
5eexO-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eexP-4ohtA:
undetectable
5eexQ-4ohtA:
undetectable		 5eexP-4ohtA:
9.89
5eexQ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5eexQ-4ohtA:
undetectable
5eexR-4ohtA:
undetectable		 5eexQ-4ohtA:
9.89
5eexR-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eexR-4ohtA:
undetectable
5eexS-4ohtA:
undetectable		 5eexR-4ohtA:
9.89
5eexS-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5eexS-4ohtA:
undetectable
5eexT-4ohtA:
undetectable		 5eexS-4ohtA:
9.89
5eexT-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eexT-4ohtA:
undetectable
5eexU-4ohtA:
undetectable		 5eexT-4ohtA:
9.89
5eexU-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.27A 5eexU-4ohtA:
undetectable
5eexV-4ohtA:
undetectable		 5eexU-4ohtA:
9.89
5eexV-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5eeyB-4ohtA:
undetectable
5eeyC-4ohtA:
undetectable		 5eeyB-4ohtA:
9.89
5eeyC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eeyC-4ohtA:
undetectable
5eeyD-4ohtA:
undetectable		 5eeyC-4ohtA:
9.89
5eeyD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eeyD-4ohtA:
undetectable
5eeyE-4ohtA:
undetectable		 5eeyD-4ohtA:
9.89
5eeyE-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eeyE-4ohtA:
undetectable
5eeyF-4ohtA:
undetectable		 5eeyE-4ohtA:
9.89
5eeyF-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5eeyG-4ohtA:
undetectable
5eeyH-4ohtA:
undetectable		 5eeyG-4ohtA:
9.89
5eeyH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eeyH-4ohtA:
undetectable
5eeyI-4ohtA:
undetectable		 5eeyH-4ohtA:
9.89
5eeyI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eeyI-4ohtA:
undetectable
5eeyJ-4ohtA:
undetectable		 5eeyI-4ohtA:
9.89
5eeyJ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5eeyJ-4ohtA:
undetectable
5eeyK-4ohtA:
undetectable		 5eeyJ-4ohtA:
9.89
5eeyK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5eeyA-4ohtA:
undetectable
5eeyK-4ohtA:
undetectable		 5eeyA-4ohtA:
9.89
5eeyK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5eeyN-4ohtA:
undetectable
5eeyO-4ohtA:
undetectable		 5eeyN-4ohtA:
9.89
5eeyO-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eeyP-4ohtA:
undetectable
5eeyQ-4ohtA:
undetectable		 5eeyP-4ohtA:
9.89
5eeyQ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5eeyQ-4ohtA:
undetectable
5eeyR-4ohtA:
undetectable		 5eeyQ-4ohtA:
9.89
5eeyR-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eeyR-4ohtA:
undetectable
5eeyS-4ohtA:
undetectable		 5eeyR-4ohtA:
9.89
5eeyS-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5eeyS-4ohtA:
undetectable
5eeyT-4ohtA:
undetectable		 5eeyS-4ohtA:
9.89
5eeyT-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eeyT-4ohtA:
undetectable
5eeyU-4ohtA:
undetectable		 5eeyT-4ohtA:
9.89
5eeyU-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5eeyU-4ohtA:
undetectable
5eeyV-4ohtA:
undetectable		 5eeyU-4ohtA:
9.89
5eeyV-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5eezB-4ohtA:
undetectable
5eezC-4ohtA:
undetectable		 5eezB-4ohtA:
9.89
5eezC-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eezC-4ohtA:
undetectable
5eezD-4ohtA:
undetectable		 5eezC-4ohtA:
9.89
5eezD-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eezD-4ohtA:
undetectable
5eezE-4ohtA:
undetectable		 5eezD-4ohtA:
9.89
5eezE-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5eezE-4ohtA:
undetectable
5eezF-4ohtA:
undetectable		 5eezE-4ohtA:
9.89
5eezF-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5eezG-4ohtA:
undetectable
5eezH-4ohtA:
undetectable		 5eezG-4ohtA:
9.89
5eezH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eezH-4ohtA:
undetectable
5eezI-4ohtA:
undetectable		 5eezH-4ohtA:
9.89
5eezI-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5eezI-4ohtA:
undetectable
5eezJ-4ohtA:
undetectable		 5eezI-4ohtA:
9.89
5eezJ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5eezJ-4ohtA:
undetectable
5eezK-4ohtA:
undetectable		 5eezJ-4ohtA:
9.89
5eezK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5eezA-4ohtA:
undetectable
5eezK-4ohtA:
undetectable		 5eezA-4ohtA:
9.89
5eezK-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5eezN-4ohtA:
undetectable
5eezO-4ohtA:
undetectable		 5eezN-4ohtA:
9.89
5eezO-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eezP-4ohtA:
undetectable
5eezQ-4ohtA:
undetectable		 5eezP-4ohtA:
9.89
5eezQ-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.25A 5eezQ-4ohtA:
undetectable
5eezR-4ohtA:
undetectable		 5eezQ-4ohtA:
9.89
5eezR-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eezR-4ohtA:
undetectable
5eezS-4ohtA:
undetectable		 5eezR-4ohtA:
9.89
5eezS-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5eezS-4ohtA:
undetectable
5eezT-4ohtA:
undetectable		 5eezS-4ohtA:
9.89
5eezT-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5eezT-4ohtA:
undetectable
5eezU-4ohtA:
undetectable		 5eezT-4ohtA:
9.89
5eezU-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.27A 5eezU-4ohtA:
undetectable
5eezV-4ohtA:
undetectable		 5eezU-4ohtA:
9.89
5eezV-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5ef0B-4ohtA:
undetectable
5ef0C-4ohtA:
undetectable		 5ef0B-4ohtA:
9.89
5ef0C-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.22A 5ef0C-4ohtA:
undetectable
5ef0D-4ohtA:
undetectable		 5ef0C-4ohtA:
9.89
5ef0D-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5ef0D-4ohtA:
undetectable
5ef0E-4ohtA:
undetectable		 5ef0D-4ohtA:
9.89
5ef0E-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5ef0E-4ohtA:
undetectable
5ef0F-4ohtA:
undetectable		 5ef0E-4ohtA:
9.89
5ef0F-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5ef0G-4ohtA:
undetectable
5ef0H-4ohtA:
undetectable		 5ef0G-4ohtA:
9.89
5ef0H-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef0H-4ohtA:
undetectable
5ef0I-4ohtA:
undetectable		 5ef0H-4ohtA:
9.89
5ef0I-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef0I-4ohtA:
undetectable
5ef0J-4ohtA:
undetectable		 5ef0I-4ohtA:
9.89
5ef0J-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5ef0J-4ohtA:
undetectable
5ef0K-4ohtA:
undetectable		 5ef0J-4ohtA:
9.89
5ef0K-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5ef0A-4ohtA:
undetectable
5ef0K-4ohtA:
undetectable		 5ef0A-4ohtA:
9.89
5ef0K-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5ef0N-4ohtA:
undetectable
5ef0O-4ohtA:
undetectable		 5ef0N-4ohtA:
9.89
5ef0O-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef0P-4ohtA:
undetectable
5ef0Q-4ohtA:
undetectable		 5ef0P-4ohtA:
9.89
5ef0Q-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5ef0Q-4ohtA:
undetectable
5ef0R-4ohtA:
undetectable		 5ef0Q-4ohtA:
9.89
5ef0R-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef0R-4ohtA:
undetectable
5ef0S-4ohtA:
undetectable		 5ef0R-4ohtA:
9.89
5ef0S-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5ef0S-4ohtA:
undetectable
5ef0T-4ohtA:
undetectable		 5ef0S-4ohtA:
9.89
5ef0T-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef0T-4ohtA:
undetectable
5ef0U-4ohtA:
undetectable		 5ef0T-4ohtA:
9.89
5ef0U-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5ef0U-4ohtA:
undetectable
5ef0V-4ohtA:
undetectable		 5ef0U-4ohtA:
9.89
5ef0V-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5ef1B-4ohtA:
undetectable
5ef1C-4ohtA:
undetectable		 5ef1B-4ohtA:
9.89
5ef1C-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef1C-4ohtA:
undetectable
5ef1D-4ohtA:
undetectable		 5ef1C-4ohtA:
9.89
5ef1D-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5ef1D-4ohtA:
undetectable
5ef1E-4ohtA:
undetectable		 5ef1D-4ohtA:
9.89
5ef1E-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5ef1E-4ohtA:
undetectable
5ef1F-4ohtA:
undetectable		 5ef1E-4ohtA:
9.89
5ef1F-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5ef1G-4ohtA:
undetectable
5ef1H-4ohtA:
undetectable		 5ef1G-4ohtA:
9.89
5ef1H-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef1H-4ohtA:
undetectable
5ef1I-4ohtA:
undetectable		 5ef1H-4ohtA:
9.89
5ef1I-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef1I-4ohtA:
undetectable
5ef1J-4ohtA:
undetectable		 5ef1I-4ohtA:
9.89
5ef1J-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5ef1J-4ohtA:
undetectable
5ef1K-4ohtA:
undetectable		 5ef1J-4ohtA:
9.89
5ef1K-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5ef1A-4ohtA:
undetectable
5ef1K-4ohtA:
undetectable		 5ef1A-4ohtA:
9.89
5ef1K-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5ef1N-4ohtA:
undetectable
5ef1O-4ohtA:
undetectable		 5ef1N-4ohtA:
9.89
5ef1O-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef1P-4ohtA:
undetectable
5ef1Q-4ohtA:
undetectable		 5ef1P-4ohtA:
9.89
5ef1Q-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.25A 5ef1Q-4ohtA:
undetectable
5ef1R-4ohtA:
undetectable		 5ef1Q-4ohtA:
9.89
5ef1R-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef1R-4ohtA:
undetectable
5ef1S-4ohtA:
undetectable		 5ef1R-4ohtA:
9.89
5ef1S-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5ef1S-4ohtA:
undetectable
5ef1T-4ohtA:
undetectable		 5ef1S-4ohtA:
9.89
5ef1T-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef1T-4ohtA:
undetectable
5ef1U-4ohtA:
undetectable		 5ef1T-4ohtA:
9.89
5ef1U-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5ef1U-4ohtA:
undetectable
5ef1V-4ohtA:
undetectable		 5ef1U-4ohtA:
9.89
5ef1V-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5ef2B-4ohtA:
undetectable
5ef2C-4ohtA:
undetectable		 5ef2B-4ohtA:
9.89
5ef2C-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef2C-4ohtA:
undetectable
5ef2D-4ohtA:
undetectable		 5ef2C-4ohtA:
9.89
5ef2D-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5ef2D-4ohtA:
undetectable
5ef2E-4ohtA:
undetectable		 5ef2D-4ohtA:
9.89
5ef2E-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5ef2E-4ohtA:
undetectable
5ef2F-4ohtA:
undetectable		 5ef2E-4ohtA:
9.89
5ef2F-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5ef2G-4ohtA:
undetectable
5ef2H-4ohtA:
undetectable		 5ef2G-4ohtA:
9.89
5ef2H-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef2H-4ohtA:
undetectable
5ef2I-4ohtA:
undetectable		 5ef2H-4ohtA:
9.89
5ef2I-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.22A 5ef2I-4ohtA:
undetectable
5ef2J-4ohtA:
undetectable		 5ef2I-4ohtA:
9.89
5ef2J-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5ef2J-4ohtA:
undetectable
5ef2K-4ohtA:
undetectable		 5ef2J-4ohtA:
9.89
5ef2K-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5ef2A-4ohtA:
undetectable
5ef2K-4ohtA:
undetectable		 5ef2A-4ohtA:
9.89
5ef2K-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5ef2N-4ohtA:
undetectable
5ef2O-4ohtA:
undetectable		 5ef2N-4ohtA:
9.89
5ef2O-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef2P-4ohtA:
undetectable
5ef2Q-4ohtA:
undetectable		 5ef2P-4ohtA:
9.89
5ef2Q-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5ef2Q-4ohtA:
undetectable
5ef2R-4ohtA:
undetectable		 5ef2Q-4ohtA:
9.89
5ef2R-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef2R-4ohtA:
undetectable
5ef2S-4ohtA:
undetectable		 5ef2R-4ohtA:
9.89
5ef2S-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5ef2S-4ohtA:
undetectable
5ef2T-4ohtA:
undetectable		 5ef2S-4ohtA:
9.89
5ef2T-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef2T-4ohtA:
undetectable
5ef2U-4ohtA:
undetectable		 5ef2T-4ohtA:
9.89
5ef2U-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5ef2U-4ohtA:
undetectable
5ef2V-4ohtA:
undetectable		 5ef2U-4ohtA:
9.89
5ef2V-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.21A 5ef3B-4ohtA:
undetectable
5ef3C-4ohtA:
undetectable		 5ef3B-4ohtA:
9.89
5ef3C-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef3C-4ohtA:
undetectable
5ef3D-4ohtA:
undetectable		 5ef3C-4ohtA:
9.89
5ef3D-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5ef3D-4ohtA:
undetectable
5ef3E-4ohtA:
undetectable		 5ef3D-4ohtA:
9.89
5ef3E-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.26A 5ef3E-4ohtA:
undetectable
5ef3F-4ohtA:
undetectable		 5ef3E-4ohtA:
9.89
5ef3F-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.25A 5ef3G-4ohtA:
undetectable
5ef3H-4ohtA:
undetectable		 5ef3G-4ohtA:
9.89
5ef3H-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef3H-4ohtA:
undetectable
5ef3I-4ohtA:
undetectable		 5ef3H-4ohtA:
9.89
5ef3I-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 11 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.23A 5ef3I-4ohtA:
undetectable
5ef3J-4ohtA:
undetectable		 5ef3I-4ohtA:
9.89
5ef3J-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 5ef3J-4ohtA:
undetectable
5ef3K-4ohtA:
undetectable		 5ef3J-4ohtA:
9.89
5ef3K-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.21A 5ef3A-4ohtA:
undetectable
5ef3K-4ohtA:
undetectable		 5ef3A-4ohtA:
9.89
5ef3K-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.30A 5ef3N-4ohtA:
undetectable
5ef3O-4ohtA:
undetectable		 5ef3N-4ohtA:
9.89
5ef3O-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef3P-4ohtA:
undetectable
5ef3Q-4ohtA:
undetectable		 5ef3P-4ohtA:
9.89
5ef3Q-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 9 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5ef3Q-4ohtA:
undetectable
5ef3R-4ohtA:
undetectable		 5ef3Q-4ohtA:
9.89
5ef3R-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef3R-4ohtA:
undetectable
5ef3S-4ohtA:
undetectable		 5ef3R-4ohtA:
9.89
5ef3S-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.24A 5ef3S-4ohtA:
undetectable
5ef3T-4ohtA:
undetectable		 5ef3S-4ohtA:
9.89
5ef3T-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.28A 5ef3T-4ohtA:
undetectable
5ef3U-4ohtA:
undetectable		 5ef3T-4ohtA:
9.89
5ef3U-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 GLY A 390
ALA A 381
THR A 409
ILE A 407
SER A 384
 None
 1.26A 5ef3U-4ohtA:
undetectable
5ef3V-4ohtA:
undetectable		 5ef3U-4ohtA:
9.89
5ef3V-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ASP A 233
ALA A 377
ILE A 270
GLY A 390
SER A 384
 None
 1.21A 5i6xA-4ohtA:
undetectable		 5i6xA-4ohtA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 388
SER A 384
ILE A 361
GLU A 360
 None
 1.07A 5n5dA-4ohtA:
5.5		 5n5dA-4ohtA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		5 / 10 ALA A 321
LEU A 322
LEU A 328
GLU A 367
VAL A 365
 None
 1.11A 5v02B-4ohtA:
1.4
5v02R-4ohtA:
undetectable		 5v02B-4ohtA:
12.75
5v02R-4ohtA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 8 ALA A  67
THR A  71
ALA A 259
TRP A 131
 None
None
None
NAP  A 501 (-4.3A)
 0.73A 5x2tI-4ohtA:
undetectable
5x2tJ-4ohtA:
undetectable
5x2tK-4ohtA:
undetectable
5x2tL-4ohtA:
undetectable		 5x2tI-4ohtA:
15.38
5x2tJ-4ohtA:
15.49
5x2tK-4ohtA:
15.38
5x2tL-4ohtA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(Streptococcus
pyogenes) 		4 / 5 GLY A 232
ASP A 234
GLN A 261
MET A  74
 None
 1.48A 5zrfB-4ohtA:
undetectable		 5zrfB-4ohtA:
20.36