SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ohx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		3 / 3 TYR A 200
ARG A 297
GLN A 154
 None
None
ADP  A 501 ( 4.7A)
 0.96A 1tw4A-4ohxA:
undetectable		 1tw4A-4ohxA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		4 / 6 ALA A  36
TYR A  49
ILE A  38
LEU A  31
 None
 0.98A 1xvaA-4ohxA:
2.3
1xvaB-4ohxA:
2.1		 1xvaA-4ohxA:
20.51
1xvaB-4ohxA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		4 / 8 ILE A 133
PHE A  60
TYR A 137
ARG A 140
 None
None
2PE  A 503 (-3.7A)
2PE  A 503 ( 4.1A)
 1.20A 3ccfB-4ohxA:
undetectable		 3ccfB-4ohxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		4 / 7 GLU A  95
GLU A  96
GLY A 114
ARG A  98
 None
 0.95A 4fgzA-4ohxA:
undetectable		 4fgzA-4ohxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		3 / 3 VAL A 234
GLY A 236
LYS A 240
 None
 0.72A 4k50A-4ohxA:
undetectable		 4k50A-4ohxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		3 / 3 VAL A 234
GLY A 236
LYS A 240
 None
 0.70A 4k50I-4ohxA:
undetectable		 4k50I-4ohxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		5 / 12 ILE A  67
ALA A  65
ILE A  38
LEU A  11
VAL A  57
 None
 1.00A 4k6iA-4ohxA:
undetectable		 4k6iA-4ohxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		4 / 8 HIS A 421
LEU A 366
LEU A 389
THR A 317
 None
 1.04A 5hs6A-4ohxA:
3.3		 5hs6A-4ohxA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 119
VAL A 253
LEU A 117
ILE A  86
LEU A 257
 None
 1.07A 5og9B-4ohxA:
undetectable		 5og9B-4ohxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		4 / 5 PRO A 183
VAL A 157
GLY A 225
VAL A 168
 None
 1.00A 6ak3B-4ohxA:
undetectable		 6ak3B-4ohxA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4ohx PROTEIN CLPF-1
(Caenorhabditis
elegans) 		4 / 6 PHE A 369
VAL A 320
LEU A 327
LEU A 414
 None
 1.01A 6e43C-4ohxA:
undetectable		 6e43C-4ohxA:
21.75