SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		4 / 8 TYR A 323
LEU A 321
ASN A 264
GLU A 334
 None
 1.03A 2bnnA-4oieA:
undetectable
2bnnB-4oieA:
undetectable		 2bnnA-4oieA:
20.75
2bnnB-4oieA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		3 / 3 THR A 230
PRO A 226
THR A 228
 None
 0.89A 316dC-4oieA:
undetectable		 316dC-4oieA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		4 / 7 ILE A 308
THR A 302
VAL A 285
ASP A 278
 None
 1.20A 4iarA-4oieA:
undetectable		 4iarA-4oieA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.32A 4qvlV-4oieA:
undetectable
4qvlb-4oieA:
undetectable		 4qvlV-4oieA:
22.45
4qvlb-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.32A 4qvlH-4oieA:
undetectable
4qvlN-4oieA:
undetectable		 4qvlH-4oieA:
22.45
4qvlN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.34A 4qvmV-4oieA:
undetectable
4qvmb-4oieA:
undetectable		 4qvmV-4oieA:
22.45
4qvmb-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.34A 4qvmH-4oieA:
undetectable
4qvmN-4oieA:
undetectable		 4qvmH-4oieA:
22.45
4qvmN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.36A 4qvpV-4oieA:
undetectable
4qvpb-4oieA:
undetectable		 4qvpV-4oieA:
22.45
4qvpb-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.36A 4qvpH-4oieA:
undetectable
4qvpN-4oieA:
undetectable		 4qvpH-4oieA:
22.45
4qvpN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.36A 4qvqV-4oieA:
undetectable
4qvqb-4oieA:
undetectable		 4qvqV-4oieA:
22.45
4qvqb-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.36A 4qvqH-4oieA:
undetectable
4qvqN-4oieA:
undetectable		 4qvqH-4oieA:
22.45
4qvqN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.35A 4qvwV-4oieA:
undetectable
4qvwb-4oieA:
undetectable		 4qvwV-4oieA:
22.45
4qvwb-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.35A 4qvwH-4oieA:
undetectable
4qvwN-4oieA:
undetectable		 4qvwH-4oieA:
22.45
4qvwN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 4qw0V-4oieA:
undetectable
4qw0b-4oieA:
undetectable		 4qw0V-4oieA:
22.45
4qw0b-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 4qw0H-4oieA:
undetectable
4qw0N-4oieA:
undetectable		 4qw0H-4oieA:
22.45
4qw0N-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 4qw1V-4oieA:
undetectable
4qw1b-4oieA:
undetectable		 4qw1V-4oieA:
22.45
4qw1b-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.34A 4qw1H-4oieA:
undetectable
4qw1N-4oieA:
undetectable		 4qw1H-4oieA:
22.45
4qw1N-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 4qw3V-4oieA:
undetectable
4qw3b-4oieA:
undetectable		 4qw3V-4oieA:
22.45
4qw3b-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 4qw3H-4oieA:
undetectable
4qw3N-4oieA:
undetectable		 4qw3H-4oieA:
22.45
4qw3N-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 4qwuV-4oieA:
undetectable
4qwub-4oieA:
undetectable		 4qwuV-4oieA:
22.45
4qwub-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 4qwuH-4oieA:
undetectable
4qwuN-4oieA:
undetectable		 4qwuH-4oieA:
22.45
4qwuN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 12 PHE A 277
LEU A 321
GLY A 249
LEU A 247
VAL A 220
 None
 1.09A 4wnwB-4oieA:
undetectable		 4wnwB-4oieA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.24A 5bxnV-4oieA:
undetectable
5bxnb-4oieA:
undetectable		 5bxnV-4oieA:
22.04
5bxnb-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.25A 5bxnH-4oieA:
undetectable
5bxnN-4oieA:
undetectable		 5bxnH-4oieA:
22.04
5bxnN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.35A 5cz7H-4oieA:
undetectable
5cz7N-4oieA:
undetectable		 5cz7H-4oieA:
22.45
5cz7N-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.34A 5d0xV-4oieA:
undetectable
5d0xb-4oieA:
undetectable		 5d0xV-4oieA:
22.45
5d0xb-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.34A 5d0xH-4oieA:
undetectable
5d0xN-4oieA:
undetectable		 5d0xH-4oieA:
22.45
5d0xN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 12 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 5l5zV-4oieA:
undetectable
5l5zb-4oieA:
undetectable		 5l5zV-4oieA:
22.45
5l5zb-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 12 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.33A 5l5zH-4oieA:
undetectable
5l5zN-4oieA:
undetectable		 5l5zH-4oieA:
22.45
5l5zN-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.31A 5l66V-4oieA:
undetectable
5l66b-4oieA:
undetectable		 5l66V-4oieA:
22.45
5l66b-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		5 / 11 SER A 348
THR A 325
ARG A 336
GLY A 332
ALA A 297
 None
 1.31A 5l66H-4oieA:
undetectable
5l66N-4oieA:
undetectable		 5l66H-4oieA:
22.45
5l66N-4oieA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		3 / 3 VAL A 273
TYR A 323
GLN A 324
 None
 0.63A 5qgkA-4oieA:
undetectable		 5qgkA-4oieA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		3 / 3 VAL A 273
TYR A 323
GLN A 324
 None
 0.61A 5qgrA-4oieA:
undetectable		 5qgrA-4oieA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		3 / 3 VAL A 273
TYR A 323
GLN A 324
 None
 0.63A 5qgtA-4oieA:
undetectable		 5qgtA-4oieA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		4 / 8 TYR A 323
ASP A 276
ASP A 278
PRO A 320
 None
 0.81A 6ag0A-4oieA:
undetectable		 6ag0A-4oieA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4oie NON-STRUCTURAL
PROTEIN NS1
(West
Nile
virus) 		4 / 8 TYR A 323
ASP A 276
ASP A 278
PRO A 320
 None
 0.77A 6ag0C-4oieA:
undetectable		 6ag0C-4oieA:
19.89