SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4oig NON-STRUCTURAL
PROTEIN 1, NS1
(Dengue
virus) 		5 / 10 GLY A 248
GLY A 249
MET A 241
ASN A 255
ILE A 224
 None
 1.45A 3fw1A-4oigA:
undetectable		 3fw1A-4oigA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4oig NON-STRUCTURAL
PROTEIN 1, NS1
(Dengue
virus) 		5 / 12 GLU A 326
GLY A 325
PHE A 323
ASP A 276
GLY A 328
 None
 1.32A 3ps9A-4oigA:
undetectable		 3ps9A-4oigA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4oig NON-STRUCTURAL
PROTEIN 1, NS1
(Dengue
virus) 		5 / 11 GLY A 295
ARG A 294
THR A 264
GLY A 266
PRO A 267
 None
 1.22A 3t8nD-4oigA:
undetectable
3t8nF-4oigA:
undetectable		 3t8nD-4oigA:
21.93
3t8nF-4oigA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 4oig NON-STRUCTURAL
PROTEIN 1, NS1
(Dengue
virus) 		5 / 11 THR A 264
GLY A 266
PRO A 267
GLY A 295
ARG A 294
 None
 1.22A 3t8nD-4oigA:
undetectable
3t8nF-4oigA:
undetectable		 3t8nD-4oigA:
21.93
3t8nF-4oigA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4oig NON-STRUCTURAL
PROTEIN 1, NS1
(Dengue
virus) 		3 / 3 LYS A 339
GLU A 340
TRP A 311
 SO4  A 406 (-2.9A)
SO4  A 406 (-4.0A)
None
 1.17A 3v4tH-4oigA:
undetectable		 3v4tH-4oigA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4oig NON-STRUCTURAL
PROTEIN 1, NS1
(Dengue
virus) 		5 / 11 GLY A 248
GLY A 249
MET A 241
ASN A 255
ILE A 246
 None
 1.49A 4zvmA-4oigA:
undetectable
4zvmB-4oigA:
undetectable		 4zvmA-4oigA:
22.58
4zvmB-4oigA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4oig NON-STRUCTURAL
PROTEIN 1, NS1
(Dengue
virus) 		5 / 9 LEU A 279
THR A 283
THR A 284
PRO A 320
ILE A 335
 None
 1.39A 5g48B-4oigA:
undetectable		 5g48B-4oigA:
18.21