SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GSE_B_EAAB224_1 (GLUTATHIONE TRANSFERASE)	4oir	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus thermophilus)	5 / 12	GLY A 37 LEU A 195 LEU A 25 LEU A 211 ALA A 214	None	1.09A	1gseB-4oirA: undetectable	1gseB-4oirA: 23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD3_A_CHDA502_0 (FERROCHELATASE)	4oir	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus thermophilus)	4 / 8	PRO A 173 SER A 204 VAL A 148 GLY A 147	None	0.99A	2qd3A-4oirA: undetectable	2qd3A-4oirA: 23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB500_0 (ILEAL BILE ACID-BINDING PROTEIN)	4oir	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus thermophilus)	4 / 7	LYS A 194 GLU A 26 VAL A 10 THR A 12	None	0.64A	3em0B-4oirA: undetectable	3em0B-4oirA: 20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_A_CVIA301_0 (REGULATORY PROTEIN TETR)	4oir	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus thermophilus)	5 / 12	MET A 140 ALA A 130 GLU A 84 LEU A 82 ILE A 79	None	1.26A	5vlmA-4oirA: undetectable	5vlmA-4oirA: 22.22

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GSE_B_EAAB224_1","GLUTATHIONE TRANSFERASE","4oir","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus thermophilus",5,"GLY A  37;LEU A 195;LEU A  25;LEU A 211;ALA A 214","None","1.09A","1gseB-4oirA:undetectable","1gseB-4oirA:23.40"],["2QD3_A_CHDA502_0","FERROCHELATASE","4oir","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus thermophilus",4,"PRO A 173;SER A 204;VAL A 148;GLY A 147","None","0.99A","2qd3A-4oirA:undetectable","2qd3A-4oirA:23.77"],["3EM0_B_CHDB500_0","ILEAL BILE ACID-BINDING PROTEIN","4oir","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus thermophilus",4,"LYS A 194;GLU A  26;VAL A  10;THR A  12","None","0.64A","3em0B-4oirA:undetectable","3em0B-4oirA:20.07"],["5VLM_A_CVIA301_0","REGULATORY PROTEIN TETR","4oir","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus thermophilus",5,"MET A 140;ALA A 130;GLU A  84;LEU A  82;ILE A  79","None","1.26A","5vlmA-4oirA:undetectable","5vlmA-4oirA:22.22"]]