SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oiy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 907
ALA A 935
PHE A 946
ILE A 987
LEU A 993
 None
 1.21A 1jolA-4oiyA:
undetectable		 1jolA-4oiyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 849
PRO A 842
ALA A 845
ILE A 846
 None
 0.87A 2aofB-4oiyA:
undetectable		 2aofB-4oiyA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 896
SER A 913
LEU A 915
 None
 0.83A 2w1bA-4oiyA:
undetectable		 2w1bA-4oiyA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 916
SER A 913
LEU A1001
ILE A1010
 None
 1.02A 3ln1C-4oiyA:
undetectable		 3ln1C-4oiyA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1002
SER A 958
MET A 975
LEU A 998
 None
 1.23A 5dzka-4oiyA:
undetectable
5dzko-4oiyA:
undetectable		 5dzka-4oiyA:
24.89
5dzko-4oiyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1002
SER A 958
MET A 975
LEU A 998
 None
 1.20A 5dzke-4oiyA:
undetectable
5dzks-4oiyA:
undetectable		 5dzke-4oiyA:
24.89
5dzks-4oiyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		4 / 6 PHE A1002
SER A 958
MET A 975
LEU A 998
 None
 1.21A 5dzkg-4oiyA:
undetectable
5dzku-4oiyA:
undetectable		 5dzkg-4oiyA:
24.89
5dzku-4oiyA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 907
ALA A 935
PHE A 946
ILE A 987
LEU A 993
PRO A 994
 None
 1.47A 5eajB-4oiyA:
undetectable		 5eajB-4oiyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4oiy PROTEIN TRANSPORT
PROTEIN SEC7
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 908
LEU A 959
LEU A 962
LEU A 998
 None
 1.08A 6f6sA-4oiyA:
undetectable
6f6sB-4oiyA:
undetectable		 6f6sA-4oiyA:
17.28
6f6sB-4oiyA:
21.05