SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oj2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		5 / 10 ALA X  45
PHE X  48
ALA X  31
LEU X  32
LEU X  28
 None
 1.07A 2bxqA-4oj2X:
undetectable		 2bxqA-4oj2X:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		3 / 3 SER X 188
THR X  72
GLN X  93
 None
 0.79A 2fk8A-4oj2X:
undetectable		 2fk8A-4oj2X:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		5 / 12 ASN X  68
HIS X 201
PRO X 191
VAL X  24
SER X 182
 None
 1.43A 2xpvA-4oj2X:
1.8		 2xpvA-4oj2X:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		4 / 4 LEU X 189
ASP X 200
VAL X 118
THR X 195
 None
 1.12A 3cyxB-4oj2X:
undetectable		 3cyxB-4oj2X:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		5 / 10 ALA X  19
GLU X  16
ALA X 161
ILE X 164
LEU X 141
 None
 1.16A 3fl9A-4oj2X:
undetectable		 3fl9A-4oj2X:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		3 / 3 ILE X  52
SER X 167
SER X 163
 None
 0.60A 3iltH-4oj2X:
undetectable		 3iltH-4oj2X:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		3 / 3 ASN X 184
ASN X 119
GLU X 134
 None
 0.90A 3kpdB-4oj2X:
undetectable		 3kpdB-4oj2X:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		5 / 10 ILE X  67
PHE X  23
ILE X 164
SER X 167
HIS X 172
 None
 1.14A 3o1cA-4oj2X:
undetectable		 3o1cA-4oj2X:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		3 / 3 THR X 179
ASN X 119
GLU X 134
 None
 0.80A 3v4tA-4oj2X:
undetectable
3v4tC-4oj2X:
undetectable		 3v4tA-4oj2X:
22.51
3v4tC-4oj2X:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		3 / 3 PRO X 225
ASN X 220
HIS X  80
 None
 0.94A 4ma3H-4oj2X:
undetectable
4ma3L-4oj2X:
undetectable		 4ma3H-4oj2X:
25.84
4ma3L-4oj2X:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		5 / 10 SER X 182
GLY X 207
ALA X 127
VAL X 131
ILE X 206
 None
 1.18A 5i3cB-4oj2X:
undetectable		 5i3cB-4oj2X:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		4 / 8 GLY X 207
ILE X 206
ASP X 200
HIS X 201
 None
 0.95A 6ag0A-4oj2X:
undetectable		 6ag0A-4oj2X:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4oj2 AQUAPORIN-2
(Homo
sapiens) 		4 / 8 GLY X 207
ILE X 206
ASP X 200
HIS X 201
 None
 0.94A 6ag0C-4oj2X:
undetectable		 6ag0C-4oj2X:
17.60