SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ojx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A   9
LEU A  47
SER A  97
LEU A  98
 None
 1.05A 1a4lC-4ojxA:
undetectable		 1a4lC-4ojxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 322
ILE A 276
TRP A 261
LEU A 310
 None
 0.98A 1j96A-4ojxA:
undetectable		 1j96A-4ojxA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 322
ILE A 276
TRP A 261
LEU A 310
 None
 1.01A 1j96B-4ojxA:
undetectable		 1j96B-4ojxA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 244
HIS A 326
HIS A 294
 ZN  A 404 (-2.4A)
ZN  A 404 ( 3.3A)
G  A 402 (-3.6A)
 0.68A 1oe1A-4ojxA:
undetectable		 1oe1A-4ojxA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 244
HIS A 326
HIS A 294
 ZN  A 404 (-2.4A)
ZN  A 404 ( 3.3A)
G  A 402 (-3.6A)
 0.68A 1oe3A-4ojxA:
undetectable		 1oe3A-4ojxA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 4 HIS A 130
VAL A 223
THR A 127
LEU A 158
 ZN  A 403 ( 3.2A)
None
None
None
 1.48A 1oq5A-4ojxA:
undetectable		 1oq5A-4ojxA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 THR A 127
SER A 225
PHE A 227
VAL A 324
HIS A 326
 None
None
None
None
ZN  A 404 ( 3.3A)
 1.47A 1q23D-4ojxA:
undetectable
1q23E-4ojxA:
undetectable		 1q23D-4ojxA:
18.90
1q23E-4ojxA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 132
HIS A 133
HIS A 213
ASP A 244
HIS A 326
 ZN  A 404 ( 2.6A)
ZN  A 404 (-3.3A)
ZN  A 403 ( 3.3A)
ZN  A 404 (-2.4A)
ZN  A 404 ( 3.3A)
 0.71A 2q0jB-4ojxA:
9.8		 2q0jB-4ojxA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 137
LEU A 186
ILE A 162
GLN A 166
PHE A 170
 None
 1.17A 2weyA-4ojxA:
undetectable		 2weyA-4ojxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 244
HIS A 326
HIS A 294
 ZN  A 404 (-2.4A)
ZN  A 404 ( 3.3A)
G  A 402 (-3.6A)
 0.70A 2xxgA-4ojxA:
undetectable		 2xxgA-4ojxA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  39
PHE A  23
LEU A  25
 None
 0.61A 2zi9A-4ojxA:
undetectable		 2zi9A-4ojxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 213
HIS A 294
HIS A 326
ASP A 132
 ZN  A 403 ( 3.3A)
G  A 402 (-3.6A)
ZN  A 404 ( 3.3A)
ZN  A 404 ( 2.6A)
 1.16A 3c0zA-4ojxA:
2.3		 3c0zA-4ojxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 260
ASP A 248
LEU A 304
ILE A 276
CYH A 242
 None
 1.42A 3ko0A-4ojxA:
undetectable
3ko0B-4ojxA:
undetectable
3ko0C-4ojxA:
undetectable
3ko0D-4ojxA:
undetectable		 3ko0A-4ojxA:
14.45
3ko0B-4ojxA:
14.45
3ko0C-4ojxA:
14.45
3ko0D-4ojxA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 244
SER A 281
HIS A 294
GLU A 363
 ZN  A 404 (-2.4A)
None
G  A 402 (-3.6A)
None
 0.97A 3sg9B-4ojxA:
undetectable		 3sg9B-4ojxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  18
GLY A  41
GLY A  19
ALA A  37
ASN A 140
 None
 1.15A 3vywB-4ojxA:
undetectable		 3vywB-4ojxA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 128
HIS A 130
ASP A 132
HIS A 213
HIS A 326
 ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
ZN  A 404 ( 2.6A)
ZN  A 403 ( 3.3A)
ZN  A 404 ( 3.3A)
 0.75A 4c1dB-4ojxA:
undetectable		 4c1dB-4ojxA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 128
HIS A 130
ASP A 132
HIS A 213
HIS A 326
 ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
ZN  A 404 ( 2.6A)
ZN  A 403 ( 3.3A)
ZN  A 404 ( 3.3A)
 0.76A 4c1fA-4ojxA:
8.8
4c1fB-4ojxA:
8.8		 4c1fA-4ojxA:
21.91
4c1fB-4ojxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 128
HIS A 130
ASP A 132
HIS A 213
HIS A 326
 ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
ZN  A 404 ( 2.6A)
ZN  A 403 ( 3.3A)
ZN  A 404 ( 3.3A)
 0.76A 4c1hA-4ojxA:
2.4		 4c1hA-4ojxA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 130
ASP A 132
HIS A 213
HIS A 326
 ZN  A 403 ( 3.2A)
ZN  A 404 ( 2.6A)
ZN  A 403 ( 3.3A)
ZN  A 404 ( 3.3A)
 0.70A 4exsB-4ojxA:
7.3		 4exsB-4ojxA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 133
HIS A 213
HIS A 326
ASP A 132
 ZN  A 404 (-3.3A)
ZN  A 403 ( 3.3A)
ZN  A 404 ( 3.3A)
ZN  A 404 ( 2.6A)
 0.97A 4h9mA-4ojxA:
undetectable		 4h9mA-4ojxA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A  36
LEU A 191
ARG A 231
PHE A 230
VAL A  38
THR A 200
 None
 1.39A 4kfjB-4ojxA:
undetectable		 4kfjB-4ojxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 257
VAL A 245
LEU A 273
LEU A 317
TYR A 311
 None
 1.32A 4o8fB-4ojxA:
undetectable		 4o8fB-4ojxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 294
HIS A 326
HIS A 128
HIS A 130
 G  A 402 (-3.6A)
ZN  A 404 ( 3.3A)
ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
 0.97A 4p6sB-4ojxA:
undetectable		 4p6sB-4ojxA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 295
GLU A 303
ASP A 248
GLY A 214
HIS A 212
 None
 1.48A 4pfjA-4ojxA:
undetectable		 4pfjA-4ojxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 295
GLU A 303
ASP A 248
GLY A 214
HIS A 212
 None
 1.45A 4pgfA-4ojxA:
undetectable		 4pgfA-4ojxA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 228
THR A 161
LEU A 158
TRP A 156
 None
 1.48A 4qztA-4ojxA:
undetectable		 4qztA-4ojxA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1298_1
(GERANYLTRANSTRANSFER
ASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 155
PHE A 170
GLN A 166
ASP A 177
 None
 1.27A 4umjA-4ojxA:
0.0		 4umjA-4ojxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 130
ASP A 132
HIS A 213
HIS A 326
 ZN  A 403 ( 3.2A)
ZN  A 404 ( 2.6A)
ZN  A 403 ( 3.3A)
ZN  A 404 ( 3.3A)
 0.69A 5a5zA-4ojxA:
7.5		 5a5zA-4ojxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		6 / 11 HIS A 128
HIS A 130
ASP A 132
HIS A 133
HIS A 213
HIS A 326
 ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
ZN  A 404 ( 2.6A)
ZN  A 404 (-3.3A)
ZN  A 403 ( 3.3A)
ZN  A 404 ( 3.3A)
 0.34A 5ayaA-4ojxA:
9.5		 5ayaA-4ojxA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 294
HIS A 326
HIS A 128
HIS A 130
LEU A 131
 G  A 402 (-3.6A)
ZN  A 404 ( 3.3A)
ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
None
 1.16A 5m8nA-4ojxA:
undetectable		 5m8nA-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 294
HIS A 326
HIS A 128
HIS A 130
LEU A 131
 G  A 402 (-3.6A)
ZN  A 404 ( 3.3A)
ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
None
 1.24A 5m8nB-4ojxA:
undetectable		 5m8nB-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 128
HIS A 326
HIS A 294
LEU A 295
 ZN  A 403 (-3.4A)
ZN  A 404 ( 3.3A)
G  A 402 (-3.6A)
None
 0.91A 5m8rA-4ojxA:
undetectable		 5m8rA-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 213
HIS A 133
HIS A 326
SER A 281
 ZN  A 403 ( 3.3A)
ZN  A 404 (-3.3A)
ZN  A 404 ( 3.3A)
None
 0.98A 5m8rA-4ojxA:
undetectable		 5m8rA-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 128
HIS A 326
HIS A 294
LEU A 295
 ZN  A 403 (-3.4A)
ZN  A 404 ( 3.3A)
G  A 402 (-3.6A)
None
 0.90A 5m8rB-4ojxA:
undetectable		 5m8rB-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 213
HIS A 133
HIS A 326
SER A 281
 ZN  A 403 ( 3.3A)
ZN  A 404 (-3.3A)
ZN  A 404 ( 3.3A)
None
 0.96A 5m8rB-4ojxA:
undetectable		 5m8rB-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 128
HIS A 326
HIS A 294
LEU A 295
 ZN  A 403 (-3.4A)
ZN  A 404 ( 3.3A)
G  A 402 (-3.6A)
None
 0.92A 5m8rD-4ojxA:
undetectable		 5m8rD-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 213
HIS A 133
HIS A 326
SER A 281
 ZN  A 403 ( 3.3A)
ZN  A 404 (-3.3A)
ZN  A 404 ( 3.3A)
None
 1.01A 5m8rD-4ojxA:
undetectable		 5m8rD-4ojxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 244
HIS A 326
HIS A 294
HIS A 128
 ZN  A 404 (-2.4A)
ZN  A 404 ( 3.3A)
G  A 402 (-3.6A)
ZN  A 403 (-3.4A)
 0.91A 5nekD-4ojxA:
undetectable		 5nekD-4ojxA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		6 / 10 HIS A 128
HIS A 130
HIS A 133
HIS A 213
ASP A 244
HIS A 294
 ZN  A 403 (-3.4A)
ZN  A 403 ( 3.2A)
ZN  A 404 (-3.3A)
ZN  A 403 ( 3.3A)
ZN  A 404 (-2.4A)
G  A 402 (-3.6A)
 0.32A 5nzwA-4ojxA:
3.1		 5nzwA-4ojxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		6 / 10 HIS A 213
HIS A 128
HIS A 294
ASP A 244
THR A  16
HIS A 326
 ZN  A 403 ( 3.3A)
ZN  A 403 (-3.4A)
G  A 402 (-3.6A)
ZN  A 404 (-2.4A)
None
ZN  A 404 ( 3.3A)
 1.37A 5nzwA-4ojxA:
3.1		 5nzwA-4ojxA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 133
ASP A 244
HIS A 326
 ZN  A 404 (-3.3A)
ZN  A 404 (-2.4A)
ZN  A 404 ( 3.3A)
 0.81A 5oexA-4ojxA:
undetectable		 5oexA-4ojxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 130
ASP A 132
HIS A 213
HIS A 326
 ZN  A 403 ( 3.2A)
ZN  A 404 ( 2.6A)
ZN  A 403 ( 3.3A)
ZN  A 404 ( 3.3A)
 0.74A 5zj8A-4ojxA:
3.4		 5zj8A-4ojxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 295
GLU A 303
ASP A 248
GLY A 214
HIS A 212
 None
 1.49A 6aphA-4ojxA:
undetectable		 6aphA-4ojxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4ojx 3',5'-CYCLIC-NUCLEOT
IDE
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 233
ARG A 231
ASP A 205
 None
 0.79A 6d8pA-4ojxA:
undetectable		 6d8pA-4ojxA:
19.22