SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ojz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 TRP A  47
ALA A  41
VAL A 105
 None
 0.87A 1av2C-4ojzA:
undetectable
1av2D-4ojzA:
undetectable		 1av2C-4ojzA:
3.59
1av2D-4ojzA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 10 ASN A 287
SER A 247
GLY A 383
GLY A 378
ASP A 249
 None
 1.33A 1ho5B-4ojzA:
undetectable		 1ho5B-4ojzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 9 GLU A 505
LEU A 419
HIS A 464
HIS A 415
GLY A 414
 None
None
ZN  A 801 (-3.3A)
ZN  A 801 (-3.2A)
None
 1.41A 1mjlA-4ojzA:
undetectable
1mjlB-4ojzA:
undetectable		 1mjlA-4ojzA:
9.36
1mjlB-4ojzA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 11 HIS A 415
GLY A 414
GLU A 505
LEU A 419
HIS A 464
 ZN  A 801 (-3.2A)
None
None
None
ZN  A 801 (-3.3A)
 1.45A 1mjqA-4ojzA:
undetectable
1mjqB-4ojzA:
undetectable		 1mjqA-4ojzA:
9.36
1mjqB-4ojzA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 10 HIS A 415
GLY A 414
GLU A 505
LEU A 419
HIS A 464
 ZN  A 801 (-3.2A)
None
None
None
ZN  A 801 (-3.3A)
 1.44A 1mjqG-4ojzA:
undetectable
1mjqH-4ojzA:
undetectable		 1mjqG-4ojzA:
9.36
1mjqH-4ojzA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 TYR A 257
HIS A 202
MET A 264
PRO A 265
ASN A 441
 BEM  A 804 (-4.8A)
MAV  A 803 (-3.8A)
None
None
BEM  A 804 ( 4.7A)
 1.47A 1mrlB-4ojzA:
undetectable
1mrlC-4ojzA:
undetectable		 1mrlB-4ojzA:
14.40
1mrlC-4ojzA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 6 PHE A 307
ARG A 392
ALA A 401
TYR A 372
 None
 1.13A 1oniH-4ojzA:
undetectable
1oniI-4ojzA:
undetectable		 1oniH-4ojzA:
12.10
1oniI-4ojzA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 LEU A 402
LEU A 656
ALA A 596
PHE A 558
VAL A 531
 None
 1.37A 1rbpA-4ojzA:
undetectable		 1rbpA-4ojzA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 TRP A  47
ALA A  41
VAL A 105
 None
 0.94A 1w5uA-4ojzA:
undetectable
1w5uB-4ojzA:
undetectable		 1w5uA-4ojzA:
3.59
1w5uB-4ojzA:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 10 VAL A 515
SER A 651
LEU A 535
VAL A 534
ASP A 688
 None
 1.35A 2c12D-4ojzA:
1.9		 2c12D-4ojzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TYR A 261
GLU A  87
HIS A  86
GLY A  82
 BEM  A 804 (-3.6A)
None
None
None
 1.16A 2ha4B-4ojzA:
undetectable		 2ha4B-4ojzA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 LYS A 314
TYR A 424
PRO A 308
 None
 1.35A 2j9cC-4ojzA:
undetectable		 2j9cC-4ojzA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 ALA A 387
GLN A 385
ASP A 417
GLY A 410
ASP A 379
 None
None
ZN  A 801 ( 4.7A)
None
None
 1.27A 2nv4A-4ojzA:
undetectable		 2nv4A-4ojzA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 10 LEU A 148
ALA A 151
GLU A 150
LEU A 188
HIS A 200
 MAV  A 803 ( 4.8A)
None
None
None
LGU  A 802 ( 4.2A)
 1.41A 2ocfA-4ojzA:
undetectable		 2ocfA-4ojzA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 MET A  68
ILE A 176
LEU A 168
GLY A 160
ILE A  96
 None
 1.20A 2ogyA-4ojzA:
undetectable		 2ogyA-4ojzA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 GLY A 355
TYR A  53
SER A 350
 None
 0.74A 2xatA-4ojzA:
undetectable		 2xatA-4ojzA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 MET A  68
ILE A 176
LEU A 168
GLY A 160
ILE A  96
 None
 1.22A 2ycjA-4ojzA:
undetectable		 2ycjA-4ojzA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 ILE A 199
GLN A 241
ASN A 197
GLY A 234
GLY A 229
 None
 1.15A 2zw9A-4ojzA:
undetectable		 2zw9A-4ojzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 9 ALA A 258
THR A 407
SER A 408
PHE A 416
ILE A 309
 None
 1.37A 3hbbB-4ojzA:
undetectable		 3hbbB-4ojzA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 ARG A 348
GLU A 322
TYR A 156
 None
 0.59A 3k37B-4ojzA:
undetectable		 3k37B-4ojzA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 11 SER A 189
LEU A 227
SER A 226
PHE A 238
ILE A 273
 None
 1.30A 3ko0A-4ojzA:
undetectable
3ko0B-4ojzA:
undetectable
3ko0C-4ojzA:
undetectable
3ko0D-4ojzA:
undetectable		 3ko0A-4ojzA:
8.97
3ko0B-4ojzA:
8.97
3ko0C-4ojzA:
8.97
3ko0D-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 11 LEU A 227
SER A 226
PHE A 238
ILE A 273
SER A 189
 None
 1.36A 3ko0C-4ojzA:
undetectable
3ko0D-4ojzA:
undetectable
3ko0E-4ojzA:
undetectable
3ko0F-4ojzA:
undetectable		 3ko0C-4ojzA:
8.97
3ko0D-4ojzA:
8.97
3ko0E-4ojzA:
8.97
3ko0F-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 11 SER A 189
LEU A 227
SER A 226
PHE A 238
ILE A 273
 None
 1.37A 3ko0C-4ojzA:
undetectable
3ko0D-4ojzA:
undetectable
3ko0E-4ojzA:
undetectable
3ko0F-4ojzA:
undetectable		 3ko0C-4ojzA:
8.97
3ko0D-4ojzA:
8.97
3ko0E-4ojzA:
8.97
3ko0F-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 11 LEU A 227
SER A 226
PHE A 238
ILE A 273
SER A 189
 None
 1.31A 3ko0E-4ojzA:
undetectable
3ko0F-4ojzA:
undetectable
3ko0G-4ojzA:
undetectable
3ko0H-4ojzA:
undetectable		 3ko0E-4ojzA:
8.97
3ko0F-4ojzA:
8.97
3ko0G-4ojzA:
8.97
3ko0H-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 LEU A 227
SER A 226
PHE A 238
ILE A 273
SER A 189
 None
 1.24A 3ko0G-4ojzA:
undetectable
3ko0H-4ojzA:
undetectable
3ko0I-4ojzA:
undetectable
3ko0J-4ojzA:
undetectable		 3ko0G-4ojzA:
8.97
3ko0H-4ojzA:
8.97
3ko0I-4ojzA:
8.97
3ko0J-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 11 SER A 189
LEU A 227
SER A 226
PHE A 238
ILE A 273
 None
 1.30A 3ko0K-4ojzA:
0.0
3ko0L-4ojzA:
undetectable
3ko0M-4ojzA:
0.0
3ko0N-4ojzA:
undetectable		 3ko0K-4ojzA:
8.97
3ko0L-4ojzA:
8.97
3ko0M-4ojzA:
8.97
3ko0N-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 11 SER A 189
LEU A 227
SER A 226
PHE A 238
ILE A 273
 None
 1.36A 3ko0Q-4ojzA:
undetectable
3ko0R-4ojzA:
undetectable
3ko0S-4ojzA:
0.0
3ko0T-4ojzA:
undetectable		 3ko0Q-4ojzA:
8.97
3ko0R-4ojzA:
8.97
3ko0S-4ojzA:
8.97
3ko0T-4ojzA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 LEU A 148
TRP A 145
GLY A  81
 MAV  A 803 ( 4.8A)
None
None
 0.64A 3l35A-4ojzA:
undetectable
3l35H-4ojzA:
undetectable		 3l35A-4ojzA:
5.66
3l35H-4ojzA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 LEU A 148
TRP A 145
GLY A  81
 MAV  A 803 ( 4.8A)
None
None
 0.67A 3l35B-4ojzA:
undetectable
3l35K-4ojzA:
undetectable		 3l35B-4ojzA:
5.66
3l35K-4ojzA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 6 PHE A 266
TYR A 252
HIS A 200
THR A 204
 None
None
LGU  A 802 ( 4.2A)
None
 1.19A 3lb3B-4ojzA:
undetectable		 3lb3B-4ojzA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 TYR A 605
HIS A 659
SER A 674
ALA A 596
LEU A 640
 None
 1.35A 3lcvB-4ojzA:
undetectable		 3lcvB-4ojzA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 8 HIS A 474
SER A 473
LEU A 581
ASP A 546
 None
 1.28A 3n2oC-4ojzA:
undetectable
3n2oD-4ojzA:
undetectable		 3n2oC-4ojzA:
22.38
3n2oD-4ojzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 GLY A 355
GLN A 346
VAL A 324
LYS A 360
ALA A 361
 None
 1.29A 3qowA-4ojzA:
undetectable		 3qowA-4ojzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 PHE A 416
ASN A 420
GLY A 414
GLY A 577
GLN A 472
 None
 1.17A 3v3oA-4ojzA:
undetectable		 3v3oA-4ojzA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 LEU A 625
LEU A 581
LEU A 572
VAL A 468
ARG A 643
 None
 1.29A 3zqtA-4ojzA:
undetectable		 3zqtA-4ojzA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TRP A 145
HIS A  86
ASN A 441
TYR A 450
 None
None
BEM  A 804 ( 4.7A)
LGU  A 802 (-4.4A)
 1.35A 4a3uA-4ojzA:
undetectable		 4a3uA-4ojzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TRP A 145
HIS A  86
ASN A 441
TYR A 450
 None
None
BEM  A 804 ( 4.7A)
LGU  A 802 (-4.4A)
 1.40A 4a3uB-4ojzA:
undetectable		 4a3uB-4ojzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 TRP A 145
HIS A  86
ASN A 441
LEU A 440
 None
None
BEM  A 804 ( 4.7A)
None
 1.39A 4awuA-4ojzA:
undetectable		 4awuA-4ojzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 ALA A 503
ALA A 404
ALA A 387
THR A 407
 None
 0.75A 4du2A-4ojzA:
undetectable		 4du2A-4ojzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 ALA A 503
ALA A 404
ALA A 387
THR A 407
 None
 0.76A 4du2B-4ojzA:
undetectable		 4du2B-4ojzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 TYR A  84
PHE A  67
ARG A  91
 None
 1.16A 4g19D-4ojzA:
undetectable		 4g19D-4ojzA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HZ2_A_BEZA302_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 6 SER A 301
ARG A 392
TYR A 424
TYR A 372
 EDO  A 805 (-2.7A)
None
None
None
 1.44A 4hz2A-4ojzA:
0.9		 4hz2A-4ojzA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 GLU A 150
THR A  85
HIS A  89
 None
 0.84A 4q15A-4ojzA:
undetectable		 4q15A-4ojzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 GLU A 150
THR A  85
HIS A  89
 None
 0.82A 4q15B-4ojzA:
undetectable		 4q15B-4ojzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 TYR A 251
GLY A 255
PRO A 256
 None
 0.51A 4qwpA-4ojzA:
undetectable		 4qwpA-4ojzA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 THR A 352
VAL A 362
LYS A 357
ALA A 361
ILE A 349
 None
 1.16A 4x1kD-4ojzA:
undetectable		 4x1kD-4ojzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 LEU A 327
THR A 352
VAL A 362
LYS A 357
ALA A 361
 None
 1.05A 4x20B-4ojzA:
undetectable		 4x20B-4ojzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 THR A 352
VAL A 362
LYS A 357
ALA A 361
ILE A 349
 None
 1.03A 4x20B-4ojzA:
undetectable		 4x20B-4ojzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 3 GLU A 150
THR A  85
HIS A  89
 None
 0.81A 4ydqB-4ojzA:
undetectable		 4ydqB-4ojzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		3 / 4 ARG A 135
GLY A 141
GLU A 131
 None
 0.63A 4z2dB-4ojzA:
1.5
4z2dC-4ojzA:
undetectable		 4z2dB-4ojzA:
20.74
4z2dC-4ojzA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 ALA A  80
TYR A 122
PHE A 181
ILE A 176
GLY A 160
 None
 1.18A 5eshA-4ojzA:
undetectable		 5eshA-4ojzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 ALA A 115
ASP A  60
THR A 352
SER A 157
TYR A 156
 None
 1.39A 5hfjG-4ojzA:
undetectable		 5hfjG-4ojzA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 6 VAL A 676
TYR A 607
VAL A 655
SER A 674
 None
 0.91A 5jwaH-4ojzA:
undetectable		 5jwaH-4ojzA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 8 ASN A 201
ALA A 258
HIS A 202
HIS A 200
 MAV  A 803 ( 4.1A)
None
MAV  A 803 (-3.8A)
LGU  A 802 ( 4.2A)
 1.08A 5km8A-4ojzA:
undetectable
5km8B-4ojzA:
undetectable		 5km8A-4ojzA:
13.07
5km8B-4ojzA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 7 ASP A 336
THR A 334
VAL A 294
TYR A 295
 None
 1.13A 5ov9A-4ojzA:
undetectable		 5ov9A-4ojzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		4 / 8 ILE A 329
TYR A 295
VAL A 358
ASP A  39
 None
 1.04A 5vlmF-4ojzA:
2.4		 5vlmF-4ojzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 11 GLY A 211
MET A 228
GLY A 229
GLN A 241
THR A 195
 None
 1.22A 5x19G-4ojzA:
undetectable
5x19N-4ojzA:
0.0
5x19O-4ojzA:
undetectable		 5x19G-4ojzA:
10.10
5x19N-4ojzA:
20.50
5x19O-4ojzA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4ojz PUTATIVE ALGINATE
LYASE
(Saccharophagus
degradans) 		5 / 12 ILE A 267
LEU A 245
GLN A 241
PRO A 265
PHE A 238
 None
 1.21A 5xxiA-4ojzA:
undetectable		 5xxiA-4ojzA:
20.97