SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4okd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 TRP A 717
ALA A 273
VAL A 277
 None
 0.92A 1bdwA-4okdA:
undetectable
1bdwB-4okdA:
undetectable		 1bdwA-4okdA:
1.43
1bdwB-4okdA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 11 LEU A 509
MET A 524
LEU A 519
VAL A 378
ILE A 433
 None
 1.35A 1ee2A-4okdA:
undetectable		 1ee2A-4okdA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 11 LEU A 509
MET A 524
LEU A 519
VAL A 378
ILE A 433
 None
 1.39A 1ee2B-4okdA:
undetectable		 1ee2B-4okdA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 ILE A 583
ASN A 551
SER A 612
ASN A 614
 None
 1.11A 1h7xB-4okdA:
4.1		 1h7xB-4okdA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 11 PHE A 561
ALA A 570
ALA A 574
VAL A 750
GLN A 756
 None
None
GLC  A1010 (-3.5A)
None
None
 1.33A 1hbpA-4okdA:
undetectable		 1hbpA-4okdA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 PHE A 730
LEU A 861
ALA A 789
GLY A 678
LEU A 682
 None
 1.13A 1igxA-4okdA:
undetectable		 1igxA-4okdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 ALA A 789
VAL A 774
TRP A 757
 None
None
GLC  A1011 ( 4.2A)
 0.91A 1micA-4okdA:
undetectable
1micB-4okdA:
undetectable		 1micA-4okdA:
1.43
1micB-4okdA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		7 / 12 TYR A 331
HIS A 382
ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 ( 3.8A)
GLC  A1001 (-4.4A)
GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.58A 1mxdA-4okdA:
21.5		 1mxdA-4okdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 5 VAL A 126
SER A 124
ASP A 189
GLN A 231
 None
 1.44A 1n2xB-4okdA:
undetectable		 1n2xB-4okdA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.41A 1p6mA-4okdA:
undetectable
1p6mB-4okdA:
undetectable		 1p6mA-4okdA:
19.20
1p6mB-4okdA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 615
GLU A 549
VAL A 537
ARG A 555
 None
None
None
GLC  A1008 (-3.1A)
 1.38A 1rs9A-4okdA:
undetectable
1rs9B-4okdA:
undetectable		 1rs9A-4okdA:
19.22
1rs9B-4okdA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 4 GLY A 678
SER A 683
VAL A 788
LEU A 734
 None
 1.36A 1yajB-4okdA:
1.1		 1yajB-4okdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 8 THR A 383
GLU A 313
THR A 333
VAL A 202
 None
GLC  A1006 (-4.7A)
None
None
 1.13A 2fb2A-4okdA:
3.2		 2fb2A-4okdA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 ASN A 551
ILE A 261
MET A 256
 None
 0.78A 2h42C-4okdA:
undetectable		 2h42C-4okdA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 SER A 103
SER A 114
LEU A 100
GLY A 101
 None
 1.02A 2j2pD-4okdA:
undetectable
2j2pF-4okdA:
undetectable		 2j2pD-4okdA:
14.49
2j2pF-4okdA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 10 PHE A 343
GLY A 281
VAL A 277
ALA A 279
LEU A 363
 None
 1.40A 3a3yA-4okdA:
undetectable		 3a3yA-4okdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 7 GLN A 177
GLY A 410
HIS A 176
HIS A 188
 None
 1.18A 3ai8A-4okdA:
undetectable		 3ai8A-4okdA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 GLN A 177
GLY A 410
HIS A 176
HIS A 188
 None
 1.13A 3ai8B-4okdA:
undetectable		 3ai8B-4okdA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.73A 3aicA-4okdA:
5.5		 3aicA-4okdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.75A 3aicB-4okdA:
5.1		 3aicB-4okdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		6 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
TYR A 331
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
GLC  A1001 ( 3.8A)
 0.72A 3aicC-4okdA:
5.3		 3aicC-4okdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.81A 3aicD-4okdA:
5.3		 3aicD-4okdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.75A 3aicE-4okdA:
5.5		 3aicE-4okdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.78A 3aicF-4okdA:
4.0		 3aicF-4okdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.75A 3aicG-4okdA:
5.6		 3aicG-4okdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.77A 3aicH-4okdA:
5.6		 3aicH-4okdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 681
GLY A 678
ASP A 754
ILE A 755
ASN A 614
 None
 1.22A 3eeoA-4okdA:
undetectable		 3eeoA-4okdA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 CYH A 684
PRO A 742
ASP A 754
 None
 0.92A 3hlwB-4okdA:
undetectable		 3hlwB-4okdA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 GLU A 511
GLU A 515
TRP A 603
 None
 1.07A 3hrdA-4okdA:
undetectable
3hrdE-4okdA:
undetectable
3hrdF-4okdA:
undetectable		 3hrdA-4okdA:
19.91
3hrdE-4okdA:
19.91
3hrdF-4okdA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 615
GLU A 549
VAL A 537
ARG A 555
 None
None
None
GLC  A1008 (-3.1A)
 1.46A 3n5pA-4okdA:
undetectable
3n5pB-4okdA:
undetectable		 3n5pA-4okdA:
20.26
3n5pB-4okdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Q_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.33A 3n5qA-4okdA:
undetectable
3n5qB-4okdA:
0.0		 3n5qA-4okdA:
20.26
3n5qB-4okdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 GLY A 390
TRP A 229
VAL A 225
 GLC  A1005 (-3.2A)
GLC  A1006 (-4.3A)
None
 0.50A 3n62B-4okdA:
undetectable		 3n62B-4okdA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 GLY A 390
TRP A 229
VAL A 225
 GLC  A1005 (-3.2A)
GLC  A1006 (-4.3A)
None
 0.53A 3n65B-4okdA:
undetectable		 3n65B-4okdA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 GLY A 390
TRP A 229
VAL A 225
 GLC  A1005 (-3.2A)
GLC  A1006 (-4.3A)
None
 0.51A 3n66B-4okdA:
undetectable		 3n66B-4okdA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLD_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 615
GLU A 549
VAL A 537
ARG A 555
 None
None
None
GLC  A1008 (-3.1A)
 1.42A 3nldA-4okdA:
0.0
3nldB-4okdA:
undetectable		 3nldA-4okdA:
20.26
3nldB-4okdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_A_H4BA511_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.46A 3nosA-4okdA:
undetectable
3nosB-4okdA:
undetectable		 3nosA-4okdA:
18.83
3nosB-4okdA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_B_H4BB1011_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 615
GLU A 549
VAL A 537
ARG A 555
 None
None
None
GLC  A1008 (-3.1A)
 1.40A 3nosA-4okdA:
undetectable
3nosB-4okdA:
undetectable		 3nosA-4okdA:
18.83
3nosB-4okdA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 LEU A 534
ALA A 460
LEU A 504
THR A 458
 None
 1.03A 3rozA-4okdA:
undetectable		 3rozA-4okdA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PRO A 508
TYR A 502
VAL A 498
THR A 458
 None
 1.03A 3tneA-4okdA:
undetectable		 3tneA-4okdA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PRO A 184
GLY A 185
ASN A 400
LEU A 406
 None
 1.00A 3zqtA-4okdA:
undetectable		 3zqtA-4okdA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 11 ASN A 700
ASN A 632
GLY A 701
SER A 698
PRO A 659
 None
 1.24A 4a6nC-4okdA:
undetectable		 4a6nC-4okdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 PHE A 730
LEU A 861
ILE A 859
TYR A 851
SER A 816
 None
 1.18A 4a83A-4okdA:
undetectable		 4a83A-4okdA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 8 SER A 356
MET A 340
ARG A 205
VAL A 347
 None
 1.34A 4capA-4okdA:
undetectable
4capB-4okdA:
undetectable		 4capA-4okdA:
17.02
4capB-4okdA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.30A 4ctzA-4okdA:
undetectable
4ctzB-4okdA:
undetectable		 4ctzA-4okdA:
19.91
4ctzB-4okdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 615
GLU A 549
VAL A 537
ARG A 555
 None
None
None
GLC  A1008 (-3.1A)
 1.41A 4ctzA-4okdA:
undetectable
4ctzB-4okdA:
undetectable		 4ctzA-4okdA:
19.91
4ctzB-4okdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 615
GLU A 549
VAL A 537
ARG A 555
 None
None
None
GLC  A1008 (-3.1A)
 1.45A 4d35A-4okdA:
undetectable
4d35B-4okdA:
0.0		 4d35A-4okdA:
19.91
4d35B-4okdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 LEU A 681
GLY A 696
THR A 677
GLY A 726
ASP A 723
 None
 0.83A 4dc3A-4okdA:
undetectable		 4dc3A-4okdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 113
ALA A 102
ALA A 234
LEU A 236
 None
 1.01A 4dtzA-4okdA:
undetectable		 4dtzA-4okdA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 PHE A 113
ALA A 102
ALA A 234
LEU A 236
 None
 1.01A 4dtzB-4okdA:
undetectable		 4dtzB-4okdA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 4 ALA A 496
VAL A 498
ASP A 494
LEU A 504
 None
 0.97A 4e7gA-4okdA:
undetectable		 4e7gA-4okdA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 TRP A 440
THR A 383
VAL A 200
SER A 394
 None
 1.11A 4iaqA-4okdA:
undetectable		 4iaqA-4okdA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 CYH A 684
PRO A 742
ASP A 754
 None
 0.93A 4pm5A-4okdA:
undetectable		 4pm5A-4okdA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.37A 4uh8A-4okdA:
undetectable
4uh8B-4okdA:
undetectable		 4uh8A-4okdA:
19.91
4uh8B-4okdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 GLY A 579
PHE A 790
PHE A 776
ALA A 574
PHE A 573
 None
None
None
GLC  A1010 (-3.5A)
None
 1.22A 4wh5A-4okdA:
undetectable		 4wh5A-4okdA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 PHE A 823
GLY A 785
LEU A 778
ALA A 740
PHE A 776
 None
 1.11A 4wnwB-4okdA:
undetectable		 4wnwB-4okdA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.40A 5adlA-4okdA:
0.0
5adlB-4okdA:
undetectable		 5adlA-4okdA:
19.91
5adlB-4okdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 ARG A 450
ASP A 452
GLU A 527
HIS A 619
ASP A 620
 GLC  A1001 (-3.3A)
GLC  A1001 (-2.0A)
GLC  A1001 (-3.2A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.47A 5csyB-4okdA:
17.6		 5csyB-4okdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 11 TYR A 331
ASP A 377
TRP A 329
ILE A 613
ILE A 525
 GLC  A1001 ( 3.8A)
None
None
None
None
 1.15A 5hw8A-4okdA:
undetectable
5hw8D-4okdA:
undetectable		 5hw8A-4okdA:
10.54
5hw8D-4okdA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 GLY A 482
GLY A 483
GLN A 467
 None
 0.45A 5imsA-4okdA:
undetectable		 5imsA-4okdA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 VAL A 686
GLU A 263
GLU A 302
 None
 0.94A 5jsdB-4okdA:
undetectable
5jsdC-4okdA:
undetectable		 5jsdB-4okdA:
24.61
5jsdC-4okdA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 10 LEU A 682
ALA A 743
ASP A 754
GLY A 784
VAL A 788
 None
 0.95A 5kr1A-4okdA:
undetectable		 5kr1A-4okdA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 THR A 151
HIS A 156
ASN A 149
 None
 0.99A 5n4tA-4okdA:
undetectable		 5n4tA-4okdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		3 / 3 GLY A 390
TRP A 229
VAL A 225
 GLC  A1005 (-3.2A)
GLC  A1006 (-4.3A)
None
 0.52A 5vuoB-4okdA:
undetectable		 5vuoB-4okdA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 7 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.42A 5vv9A-4okdA:
undetectable
5vv9B-4okdA:
undetectable		 5vv9A-4okdA:
19.91
5vv9B-4okdA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 8 HIS A 849
HIS A 758
THR A 777
TRP A 809
 None
 1.25A 5yj1G-4okdA:
undetectable
5yj1Y-4okdA:
undetectable		 5yj1G-4okdA:
8.82
5yj1Y-4okdA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 8 HIS A 758
THR A 777
TRP A 809
HIS A 849
 None
 1.30A 5yj1k-4okdA:
undetectable
5yj1t-4okdA:
undetectable		 5yj1k-4okdA:
8.82
5yj1t-4okdA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 5 HIS A 382
ALA A 384
SER A 332
TYR A 314
 GLC  A1001 (-4.4A)
None
GLC  A1003 ( 4.7A)
GLC  A1003 ( 4.4A)
 1.38A 5yodF-4okdA:
undetectable		 5yodF-4okdA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		5 / 12 TYR A 331
HIS A 382
ASP A 452
HIS A 619
ASP A 620
 GLC  A1001 ( 3.8A)
GLC  A1001 (-4.4A)
GLC  A1001 (-2.0A)
GLC  A1001 (-4.0A)
GLC  A1001 (-2.7A)
 0.44A 6ag0A-4okdA:
18.6		 6ag0A-4okdA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB604_0
(AMINE OXIDASE LKCE)		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 4 HIS A 610
PRO A 609
ALA A 611
ARG A 607
 None
 1.28A 6f32B-4okdA:
0.0		 6f32B-4okdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4okd ISOAMYLASE
(Chlamydomonas
reinhardtii) 		4 / 6 VAL A 537
ARG A 555
PHE A 615
GLU A 549
 None
GLC  A1008 (-3.1A)
None
None
 1.40A 9nseA-4okdA:
undetectable
9nseB-4okdA:
0.0		 9nseA-4okdA:
20.26
9nseB-4okdA:
20.26