SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4okh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4okh CALPAIN-3
(Homo
sapiens) 		5 / 11 LEU A 758
ASN A 752
TYR A 770
PHE A 786
LEU A 789
 None
 1.05A 3bgrA-4okhA:
undetectable
3bgrB-4okhA:
0.9		 3bgrA-4okhA:
14.31
3bgrB-4okhA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4okh CALPAIN-3
(Homo
sapiens) 		5 / 12 PHE A 717
PHE A 654
ILE A 661
VAL A 681
VAL A 680
 None
 1.33A 4yfbC-4okhA:
undetectable		 4yfbC-4okhA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_F_PACF601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4okh CALPAIN-3
(Homo
sapiens) 		5 / 12 PHE A 717
PHE A 654
ILE A 661
VAL A 681
VAL A 680
 None
 1.35A 4yfbF-4okhA:
undetectable		 4yfbF-4okhA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4okh CALPAIN-3
(Homo
sapiens) 		5 / 12 PHE A 717
PHE A 654
ILE A 661
VAL A 681
VAL A 680
 None
 1.36A 4yfbI-4okhA:
undetectable		 4yfbI-4okhA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 4okh CALPAIN-3
(Homo
sapiens) 		5 / 12 PHE A 717
PHE A 654
ILE A 661
VAL A 681
VAL A 680
 None
 1.35A 4yfbL-4okhA:
undetectable		 4yfbL-4okhA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4okh CALPAIN-3
(Homo
sapiens) 		3 / 3 THR A 767
SER A 744
ASP A 778
 None
 0.80A 5kvaA-4okhA:
undetectable		 5kvaA-4okhA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 4okh CALPAIN-3
(Homo
sapiens) 		3 / 3 HIS A 719
ASN A 722
ALA A 726
 None
 0.19A 5n4tB-4okhA:
undetectable		 5n4tB-4okhA:
17.15