SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4okm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 9 ILE A  38
TRP A  77
ASP A  83
LEU A  43
GLY A  84
 None
None
MG  A 901 ( 4.7A)
None
None
 1.48A 1ju6B-4okmA:
undetectable		 1ju6B-4okmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 10 ILE A  38
TRP A  77
ASP A  83
LEU A  43
GLY A  84
 None
None
MG  A 901 ( 4.7A)
None
None
 1.49A 1ju6C-4okmA:
undetectable		 1ju6C-4okmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 11 ILE A  38
TRP A  77
ASP A  83
LEU A  43
GLY A  84
 None
None
MG  A 901 ( 4.7A)
None
None
 1.48A 1ju6D-4okmA:
undetectable		 1ju6D-4okmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 12 LEU A  60
SER A 293
LEU A 294
TYR A 290
GLU A 192
 None
 1.44A 1mmkA-4okmA:
undetectable		 1mmkA-4okmA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		3 / 3 PHE A 227
LEU A  10
MET A 269
 None
 0.88A 1mx1D-4okmA:
undetectable		 1mx1D-4okmA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		4 / 4 SER A 322
ILE A 306
VAL A   7
THR A 329
 None
 1.24A 1u70A-4okmA:
undetectable		 1u70A-4okmA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 12 PHE A  55
GLY A  53
ASP A  73
THR A  29
PHE A 297
 None
 1.41A 3a25A-4okmA:
undetectable		 3a25A-4okmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		4 / 6 VAL A  67
VAL A  68
GLN A  28
PHE A  74
 None
 1.16A 3bjwF-4okmA:
undetectable		 3bjwF-4okmA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		3 / 3 THR A 221
ASP A 181
GLU A  87
 None
None
MG  A 901 (-2.6A)
 0.82A 3qowA-4okmA:
undetectable		 3qowA-4okmA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		3 / 3 ASP A 223
TRP A 345
SER A  12
 None
 1.03A 4lrhA-4okmA:
undetectable		 4lrhA-4okmA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		4 / 8 GLU A 203
GLU A 198
GLU A 192
LEU A 191
 None
 0.78A 4mj8A-4okmA:
undetectable		 4mj8A-4okmA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 11 ILE A  59
ALA A  57
PHE A  55
LEU A  71
ALA A  72
 None
 1.13A 4nqaA-4okmA:
undetectable		 4nqaA-4okmA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 12 SER A 293
HIS A 195
TYR A 197
VAL A 209
LEU A  60
 None
 1.44A 4o8fA-4okmA:
0.6		 4o8fA-4okmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_A_212A404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		7 / 9 ASP A  82
ARG A 178
ASN A 224
SER A 228
GLU A 232
ARG A 310
TYR A 311
 MG  A 902 ( 2.5A)
PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 0.95A 5dz2A-4okmA:
36.3		 5dz2A-4okmA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZ2_B_212B404_1
(GERMACRADIENOL/GEOSM
IN SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		7 / 9 ASP A  82
ARG A 178
ASN A 224
SER A 228
GLU A 232
ARG A 310
TYR A 311
 MG  A 902 ( 2.5A)
PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 0.90A 5dz2B-4okmA:
36.0		 5dz2B-4okmA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		7 / 10 ARG A 178
ASN A 224
SER A 228
LYS A 231
GLU A 232
ARG A 310
TYR A 311
 PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
PPV  A 904 (-2.8A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 0.50A 5ermA-4okmA:
23.8		 5ermA-4okmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_A_210A401_1
(FUSICOCCADIENE
SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 10 ASP A  82
ARG A 178
ASN A 224
ARG A 310
TYR A 311
 MG  A 902 ( 2.5A)
PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 1.45A 5ermA-4okmA:
23.8		 5ermA-4okmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		7 / 9 ARG A 178
ASN A 224
SER A 228
LYS A 231
GLU A 232
ARG A 310
TYR A 311
 PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
PPV  A 904 (-2.8A)
MG  A 903 ( 2.7A)
PPV  A 904 (-3.9A)
PPV  A 904 (-4.4A)
 0.52A 5ermB-4okmA:
24.5		 5ermB-4okmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERM_B_210B704_1
(FUSICOCCADIENE
SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 9 ASP A  82
ARG A 178
ASN A 224
SER A 228
ARG A 310
 MG  A 902 ( 2.5A)
PPV  A 904 (-2.9A)
MG  A 903 ( 2.7A)
MG  A 903 ( 2.3A)
PPV  A 904 (-3.9A)
 0.82A 5ermB-4okmA:
24.5		 5ermB-4okmA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		3 / 3 THR A 221
ASP A 181
GLU A  87
 None
None
MG  A 901 (-2.6A)
 0.79A 5fa8A-4okmA:
undetectable		 5fa8A-4okmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 12 LEU A 102
TRP A  77
LEU A 129
PHE A 153
ALA A 183
 None
 1.22A 5iepA-4okmA:
undetectable		 5iepA-4okmA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		4 / 8 PHE A 272
ARG A 299
ILE A 298
GLY A 300
 None
 0.84A 5nzxA-4okmA:
undetectable		 5nzxA-4okmA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		4 / 8 GLU A  34
GLY A  45
LEU A  47
THR A  49
 None
 1.04A 5syjA-4okmA:
undetectable		 5syjA-4okmA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 12 PHE A  55
ILE A  59
LEU A  71
GLY A 182
LEU A  78
 None
None
None
PPV  A 904 ( 3.8A)
None
 1.01A 5zwrA-4okmA:
undetectable		 5zwrA-4okmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 12 ILE A 219
SER A  12
PHE A 297
GLY A 300
PHE A  55
 None
 1.10A 6dwnC-4okmA:
0.0		 6dwnC-4okmA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 12 ILE A 219
SER A  12
PHE A 297
GLY A 300
PHE A  55
 None
 1.08A 6dwnD-4okmA:
undetectable		 6dwnD-4okmA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_F_LLLF301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		4 / 5 ASP A 225
TYR A 174
ASP A 181
CYH A  86
 None
 1.39A 6mn5F-4okmA:
0.0		 6mn5F-4okmA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 10 ILE A  38
TRP A  77
ASP A  83
LEU A  43
GLY A  84
 None
None
MG  A 901 ( 4.7A)
None
None
 1.48A 6r2eB-4okmA:
undetectable		 6r2eB-4okmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 10 ILE A  38
TRP A  77
ASP A  83
LEU A  43
GLY A  84
 None
None
MG  A 901 ( 4.7A)
None
None
 1.48A 6r2eC-4okmA:
undetectable		 6r2eC-4okmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4okm TERPENE SYNTHASE
METAL-BINDING
DOMAIN-CONTAINING
PROTEIN
(Streptomyces
pristinaespirali
s) 		5 / 10 ILE A  38
TRP A  77
ASP A  83
LEU A  43
GLY A  84
 None
None
MG  A 901 ( 4.7A)
None
None
 1.49A 6r2eD-4okmA:
undetectable		 6r2eD-4okmA:
20.76