SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4okr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 12 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.93A 1crbA-4okrA:
undetectable		 1crbA-4okrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		4 / 7 SER A  84
ILE A  87
ILE A  81
ASP A  82
 None
 0.99A 1yc5A-4okrA:
3.8		 1yc5A-4okrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		4 / 7 SER A  84
SER A  86
SER A 154
THR A 155
 None
 0.82A 2i91A-4okrA:
6.1		 2i91A-4okrA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		4 / 7 SER A  84
SER A  86
SER A 154
THR A 155
 None
 0.81A 2i91B-4okrA:
9.2		 2i91B-4okrA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		3 / 3 MET A 186
VAL A 198
GLU A 190
 None
 0.83A 2x9gA-4okrA:
2.6		 2x9gA-4okrA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 11 THR A 155
LEU A  80
GLY A 160
VAL A 198
ASP A 194
 None
 1.28A 3lxiB-4okrA:
undetectable		 3lxiB-4okrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 10 THR A 155
LEU A  80
GLY A 160
VAL A 198
ASP A 194
 None
 1.30A 4c9pB-4okrA:
undetectable		 4c9pB-4okrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		4 / 5 ARG A 173
ALA A 135
GLY A 109
PRO A 110
 None
 0.70A 4u9uA-4okrA:
2.6		 4u9uA-4okrA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		4 / 5 ARG A 173
ALA A 135
GLY A 109
PRO A 110
 None
 0.70A 4u9uB-4okrA:
2.7		 4u9uB-4okrA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 12 ILE A 256
LEU A  99
PHE A 102
ILE A  77
LEU A 106
 None
 1.14A 4x5hA-4okrA:
undetectable		 4x5hA-4okrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 12 ILE A 256
LEU A  99
PHE A 102
ILE A  77
LEU A 106
 None
 1.13A 5e8qB-4okrA:
undetectable		 5e8qB-4okrA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 12 ILE A 256
LEU A  99
PHE A 102
ILE A  77
LEU A 106
 None
 1.12A 5eajB-4okrA:
undetectable		 5eajB-4okrA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 12 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.90A 5h8tA-4okrA:
undetectable		 5h8tA-4okrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 12 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
 None
 0.88A 5hbsA-4okrA:
undetectable		 5hbsA-4okrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		4 / 4 GLY A 217
ALA A 247
MET A 186
THR A 254
 None
 1.10A 5n0sB-4okrA:
undetectable		 5n0sB-4okrA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 10 LEU A 103
ILE A  81
LEU A  80
LEU A 168
LEU A 182
 None
 1.25A 5y7pH-4okrA:
undetectable		 5y7pH-4okrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		5 / 9 VAL A 117
GLY A 109
VAL A 113
ASP A 137
PRO A 107
 None
 1.19A 5zniA-4okrA:
3.2		 5zniA-4okrA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 4okr MICRONEMAL PROTEIN
MIC2
(Toxoplasma
gondii) 		4 / 5 ILE A  87
SER A  84
ALA A 215
LEU A 252
 None
 1.06A 6dwnA-4okrA:
undetectable		 6dwnA-4okrA:
13.67