SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
5 / 12 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
None
0.95A 1crbA-4okuA:
undetectable
1crbA-4okuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
4 / 5 ARG A 176
LEU A 168
ASP A  76
LEU A  75
None
1.28A 1n13B-4okuA:
undetectable
1n13C-4okuA:
undetectable
1n13B-4okuA:
15.61
1n13C-4okuA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
4 / 7 SER A  84
ILE A  87
ILE A  81
ASP A  82
None
1.00A 1yc5A-4okuA:
3.7
1yc5A-4okuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
4 / 7 SER A  84
SER A  86
SER A 154
THR A 155
None
0.87A 2i91A-4okuA:
9.2
2i91A-4okuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
4 / 7 SER A  84
SER A  86
SER A 154
THR A 155
None
0.87A 2i91B-4okuA:
8.7
2i91B-4okuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
4 / 7 PRO A 180
ILE A 210
PRO A 303
GLY A 304
None
0.99A 2y7kA-4okuA:
undetectable
2y7kA-4okuA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
4 / 5 ARG A 173
ALA A 135
GLY A 109
PRO A 110
None
0.89A 4u9uA-4okuA:
2.7
4u9uA-4okuA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
4 / 5 ARG A 173
ALA A 135
GLY A 109
PRO A 110
None
0.84A 4u9uB-4okuA:
2.7
4u9uB-4okuA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
5 / 12 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
None
0.90A 5h8tA-4okuA:
undetectable
5h8tA-4okuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
5 / 12 PHE A  98
LEU A 245
ALA A 255
ILE A 108
ILE A 184
None
0.90A 5hbsA-4okuA:
undetectable
5hbsA-4okuA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
5 / 12 LEU A 214
GLY A 185
VAL A 183
PHE A  98
LEU A 260
None
1.41A 5uc3B-4okuA:
undetectable
5uc3B-4okuA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
5 / 10 LEU A 103
ILE A  81
LEU A  80
LEU A 168
LEU A 182
None
1.26A 5y7pD-4okuA:
undetectable
5y7pD-4okuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii)
5 / 9 VAL A 117
GLY A 109
VAL A 113
ASP A 137
PRO A 107
None
1.17A 5zniA-4okuA:
3.0
5zniA-4okuA:
14.94