SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ol0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 10 LEU B 353
ILE B 369
LEU B 328
GLU B 325
LEU B 324
 None
 1.02A 1cqpA-4ol0B:
undetectable
1cqpB-4ol0B:
undetectable		 1cqpA-4ol0B:
11.89
1cqpB-4ol0B:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 THR B 784
ALA B 782
LEU B 767
LEU B 799
LEU B 752
 None
 1.36A 1eiiA-4ol0B:
undetectable		 1eiiA-4ol0B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 10 LEU B 376
LEU B 372
ILE B 414
PHE B 442
ILE B 447
 None
 1.37A 1i18A-4ol0B:
undetectable
1i18B-4ol0B:
undetectable		 1i18A-4ol0B:
9.31
1i18B-4ol0B:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 10 PHE B 442
ILE B 447
LEU B 376
LEU B 372
ILE B 414
 None
 1.38A 1i18A-4ol0B:
undetectable
1i18B-4ol0B:
undetectable		 1i18A-4ol0B:
9.31
1i18B-4ol0B:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 4 HIS B 632
VAL B 626
THR B 578
LEU B 572
 None
 1.40A 1oq5A-4ol0B:
undetectable		 1oq5A-4ol0B:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 7 VAL B 188
VAL B 231
LEU B 232
LEU B 198
 None
 0.84A 1pthA-4ol0B:
2.2		 1pthA-4ol0B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 7 VAL B 188
VAL B 231
LEU B 232
LEU B 198
 None
 0.84A 1pthB-4ol0B:
2.2		 1pthB-4ol0B:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		6 / 12 SER B 238
LEU B 276
TYR B 295
VAL B 231
ALA B 245
SER B 246
 None
 1.48A 1pxxC-4ol0B:
undetectable		 1pxxC-4ol0B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 LEU B  90
SER B  85
GLU B  77
SER B  74
GLN B  72
 None
 1.48A 1s2aA-4ol0B:
undetectable		 1s2aA-4ol0B:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 LEU B   8
LEU B  50
LEU B  51
MET B  67
LEU B  37
 None
 1.36A 1sqnA-4ol0B:
undetectable		 1sqnA-4ol0B:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 11 HIS B 281
ILE B 329
THR B 278
ALA B 279
VAL B 338
 None
 1.20A 2gl0B-4ol0B:
undetectable
2gl0C-4ol0B:
undetectable		 2gl0B-4ol0B:
12.43
2gl0C-4ol0B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 ILE B 329
THR B 278
ALA B 279
VAL B 338
HIS B 281
 None
 1.19A 2gl0A-4ol0B:
undetectable
2gl0C-4ol0B:
undetectable		 2gl0A-4ol0B:
12.43
2gl0C-4ol0B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 HIS B 281
ILE B 329
THR B 278
ALA B 279
VAL B 338
 None
 1.16A 2gl0D-4ol0B:
undetectable
2gl0E-4ol0B:
undetectable		 2gl0D-4ol0B:
12.43
2gl0E-4ol0B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 11 HIS B 281
ILE B 329
THR B 278
ALA B 279
VAL B 338
 None
 1.17A 2gl0E-4ol0B:
undetectable
2gl0F-4ol0B:
undetectable		 2gl0E-4ol0B:
12.43
2gl0F-4ol0B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 11 ILE B 329
THR B 278
ALA B 279
VAL B 338
HIS B 281
 None
 1.23A 2gl0D-4ol0B:
undetectable
2gl0F-4ol0B:
undetectable		 2gl0D-4ol0B:
12.43
2gl0F-4ol0B:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 7 LEU B 307
PHE B 345
ILE B 310
PHE B 365
 None
 0.96A 2opxA-4ol0B:
undetectable		 2opxA-4ol0B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 LEU B   8
LEU B  50
LEU B  51
MET B  67
LEU B  37
 None
 1.39A 2w8yB-4ol0B:
undetectable		 2w8yB-4ol0B:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		3 / 3 MET B 199
VAL B 180
GLU B 152
 None
 0.77A 2x9gA-4ol0B:
undetectable		 2x9gA-4ol0B:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 LEU B   8
LEU B  50
LEU B  51
MET B  67
LEU B  37
 None
 1.41A 3d90A-4ol0B:
undetectable		 3d90A-4ol0B:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 11 ALA B 244
LEU B 228
VAL B 231
ILE B 298
LEU B 276
 None
 1.12A 3fl9C-4ol0B:
undetectable		 3fl9C-4ol0B:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 ALA B 244
LEU B 228
VAL B 231
ILE B 298
LEU B 276
 None
 1.13A 3fl9G-4ol0B:
undetectable		 3fl9G-4ol0B:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 9 ALA B 244
LEU B 228
VAL B 231
ILE B 298
LEU B 276
 None
 1.12A 3fl9H-4ol0B:
undetectable		 3fl9H-4ol0B:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 6 ILE B 781
ALA B 782
THR B 785
THR B 840
 None
 1.11A 3mdrA-4ol0B:
undetectable		 3mdrA-4ol0B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 VAL B 154
LEU B 147
LEU B 173
ALA B 113
LEU B 117
 None
 1.25A 3pghA-4ol0B:
undetectable		 3pghA-4ol0B:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 LEU B 232
THR B 323
ILE B 310
LEU B 253
VAL B 249
 None
 1.26A 3sp9A-4ol0B:
undetectable		 3sp9A-4ol0B:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 5 LEU B 701
ALA B 756
THR B 732
PHE B 753
 None
 1.22A 3vasB-4ol0B:
undetectable		 3vasB-4ol0B:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 8 PHE B  62
SER B  47
GLU B 153
ASP B 114
 None
 1.40A 4qb9D-4ol0B:
0.4		 4qb9D-4ol0B:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 8 LEU B 143
LEU B 184
THR B 179
TYR B 176
 None
 1.13A 5hbsA-4ol0B:
undetectable		 5hbsA-4ol0B:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		4 / 8 GLN B 682
ASP B 723
VAL B 708
GLY B 712
 None
 1.05A 5nzyA-4ol0B:
undetectable		 5nzyA-4ol0B:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 PHE B 733
LEU B 735
GLY B 741
VAL B 749
THR B 748
 None
 1.34A 5o4yD-4ol0B:
undetectable
5o4yE-4ol0B:
undetectable		 5o4yD-4ol0B:
1.49
5o4yE-4ol0B:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 LEU B 612
LEU B 615
ALA B 616
LEU B 666
ILE B 658
 None
 0.99A 5toaA-4ol0B:
undetectable		 5toaA-4ol0B:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ol0 TRANSPORTIN-3
(Homo
sapiens) 		5 / 12 LEU B  91
ILE B 112
GLN B 118
ILE B 169
LEU B 173
 None
 1.23A 5y2tB-4ol0B:
undetectable		 5y2tB-4ol0B:
undetectable