SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ol8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		3 / 3 SER A 139
HIS A 417
ASP A 449
 None
 0.74A 2oxtA-4ol8A:
undetectable		 2oxtA-4ol8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 187
ILE A  55
ALA A 123
THR A 119
GLU A 179
 None
 1.28A 2v0mC-4ol8A:
undetectable		 2v0mC-4ol8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 421
LEU A 416
VAL A 371
ALA A 366
THR A 356
 None
 1.06A 3dh0B-4ol8A:
undetectable		 3dh0B-4ol8A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 298
PHE A 302
TYR A 299
ALA A 268
 None
 0.85A 3l4dA-4ol8A:
undetectable		 3l4dA-4ol8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		4 / 7 HIS A  51
ILE A 159
TYR A 156
PRO A 191
 None
None
None
G  C   3 ( 4.2A)
 1.19A 4g5jA-4ol8A:
undetectable		 4g5jA-4ol8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 409
PHE A 412
LEU A 355
THR A 356
ARG A 300
 None
None
None
None
A  C   8 ( 4.2A)
 1.03A 5hnxB-4ol8A:
undetectable		 5hnxB-4ol8A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 368
PHE A 384
LEU A 416
PHE A 421
 None
 1.12A 5iy5P-4ol8A:
undetectable
5iy5W-4ol8A:
undetectable		 5iy5P-4ol8A:
17.25
5iy5W-4ol8A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 368
PHE A 384
LEU A 416
PHE A 421
 None
 1.09A 5w97C-4ol8A:
undetectable
5w97J-4ol8A:
undetectable		 5w97C-4ol8A:
17.66
5w97J-4ol8A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 368
PHE A 384
LEU A 416
PHE A 421
 None
 1.05A 5xdxC-4ol8A:
undetectable
5xdxJ-4ol8A:
undetectable		 5xdxC-4ol8A:
17.73
5xdxJ-4ol8A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4ol8 REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 368
PHE A 384
LEU A 416
PHE A 421
 None
 1.10A 5xdxP-4ol8A:
undetectable
5xdxW-4ol8A:
undetectable		 5xdxP-4ol8A:
17.73
5xdxW-4ol8A:
9.90