SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ole'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4ole NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 419
LYS A 394
GLN A 387
PHE A 446
 None
 1.04A 2jn3A-4oleA:
undetectable		 2jn3A-4oleA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 4ole NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		5 / 10 VAL A 472
VAL A 429
VAL A 431
PRO A 432
VAL A 444
 None
 1.06A 2nnjA-4oleA:
undetectable		 2nnjA-4oleA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4ole NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A 429
VAL A 442
TRP A 459
 None
 0.86A 3l8lA-4oleA:
undetectable
3l8lB-4oleA:
undetectable		 3l8lA-4oleA:
9.26
3l8lB-4oleA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 4ole NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 380
ILE A 476
CYH A 474
ASP A 428
SER A 423
 None
 1.48A 3m0wE-4oleA:
undetectable
3m0wF-4oleA:
undetectable
3m0wG-4oleA:
undetectable
3m0wH-4oleA:
undetectable		 3m0wE-4oleA:
18.80
3m0wF-4oleA:
18.80
3m0wG-4oleA:
18.80
3m0wH-4oleA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_I_P77I203_1
(PROTEIN S100-A4)		 4ole NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 380
ILE A 476
CYH A 474
ASP A 428
SER A 423
 None
 1.47A 3m0wA-4oleA:
undetectable
3m0wB-4oleA:
undetectable
3m0wI-4oleA:
undetectable
3m0wJ-4oleA:
undetectable		 3m0wA-4oleA:
18.80
3m0wB-4oleA:
18.80
3m0wI-4oleA:
18.80
3m0wJ-4oleA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4ole NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A 404
LYS A 399
MET A 398
 EDO  A1005 (-3.9A)
SO4  A1002 (-2.6A)
None
 1.06A 5nknA-4oleA:
undetectable		 5nknA-4oleA:
21.67