SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4oln'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_A_ACTA3001_0 (BETA-CARBONIC ANHYDRASE)	4oln	ANCSR1 (synthetic construct)	4 / 8	CYH A 10 ASP A 12 CYH A 24 GLY A 26	ZN A 101 (-2.2A) None ZN A 101 (-2.3A) None	0.81A	1ekjA-4olnA: undetectable 1ekjB-4olnA: undetectable	1ekjA-4olnA: 15.60 1ekjB-4olnA: 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EKJ_G_ACTG3002_0 (BETA-CARBONIC ANHYDRASE)	4oln	ANCSR1 (synthetic construct)	4 / 8	CYH A 10 ASP A 12 CYH A 24 GLY A 26	ZN A 101 (-2.2A) None ZN A 101 (-2.3A) None	0.80A	1ekjG-4olnA: undetectable 1ekjH-4olnA: undetectable	1ekjG-4olnA: 15.60 1ekjH-4olnA: 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PWY_E_AC2E290_1 (PURINE NUCLEOSIDE PHOSPHORYLASE)	4oln	ANCSR1 (synthetic construct)	5 / 10	GLY A 71 PHE A 31 VAL A 21 GLY A 20 VAL A 70	None	1.22A	1pwyE-4olnA: undetectable	1pwyE-4olnA: 14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UCJ_A_AZMA229_1 (CARBONIC ANHYDRASE)	4oln	ANCSR1 (synthetic construct)	5 / 10	CYH A 10 ASP A 12 CYH A 24 GLY A 26 ALA A 29	ZN A 101 (-2.2A) None ZN A 101 (-2.3A) None None	1.20A	3ucjA-4olnA: undetectable	3ucjA-4olnA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UCJ_B_AZMB229_2 (CARBONIC ANHYDRASE)	4oln	ANCSR1 (synthetic construct)	5 / 10	CYH A 10 ASP A 12 CYH A 24 GLY A 26 ALA A 29	ZN A 101 (-2.2A) None ZN A 101 (-2.3A) None None	1.21A	3ucjB-4olnA: undetectable	3ucjB-4olnA: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DBY_A_ACTA610_0 (SERUM ALBUMIN)	4oln	ANCSR1 (synthetic construct)	3 / 3	TYR A 19 LYS A 32 LYS A 28	None	0.71A	5dbyA-4olnA: undetectable	5dbyA-4olnA: 10.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1EKJ_A_ACTA3001_0","BETA-CARBONIC ANHYDRASE","4oln","ANCSR1","synthetic construct",4,"CYH A  10;ASP A  12;CYH A  24;GLY A  26"," ZN A 101 (-2.2A);None; ZN A 101 (-2.3A);None","0.81A","1ekjA-4olnA:undetectable;1ekjB-4olnA:undetectable","1ekjA-4olnA:15.60;1ekjB-4olnA:15.60"],["1EKJ_G_ACTG3002_0","BETA-CARBONIC ANHYDRASE","4oln","ANCSR1","synthetic construct",4,"CYH A  10;ASP A  12;CYH A  24;GLY A  26"," ZN A 101 (-2.2A);None; ZN A 101 (-2.3A);None","0.80A","1ekjG-4olnA:undetectable;1ekjH-4olnA:undetectable","1ekjG-4olnA:15.60;1ekjH-4olnA:15.60"],["1PWY_E_AC2E290_1","PURINE NUCLEOSIDE PHOSPHORYLASE","4oln","ANCSR1","synthetic construct",5,"GLY A  71;PHE A  31;VAL A  21;GLY A  20;VAL A  70","None","1.22A","1pwyE-4olnA:undetectable","1pwyE-4olnA:14.76"],["3UCJ_A_AZMA229_1","CARBONIC ANHYDRASE","4oln","ANCSR1","synthetic construct",5,"CYH A  10;ASP A  12;CYH A  24;GLY A  26;ALA A  29"," ZN A 101 (-2.2A);None; ZN A 101 (-2.3A);None;None","1.20A","3ucjA-4olnA:undetectable","3ucjA-4olnA:21.43"],["3UCJ_B_AZMB229_2","CARBONIC ANHYDRASE","4oln","ANCSR1","synthetic construct",5,"CYH A  10;ASP A  12;CYH A  24;GLY A  26;ALA A  29"," ZN A 101 (-2.2A);None; ZN A 101 (-2.3A);None;None","1.21A","3ucjB-4olnA:undetectable","3ucjB-4olnA:21.43"],["5DBY_A_ACTA610_0","SERUM ALBUMIN","4oln","ANCSR1","synthetic construct",3,"TYR A  19;LYS A  32;LYS A  28","None","0.71A","5dbyA-4olnA:undetectable","5dbyA-4olnA:10.74"]]