SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4om8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		5 / 10 ILE A   2
ILE A 164
VAL A 150
LEU A  21
ARG A  20
 None
 1.09A 3elzC-4om8A:
undetectable		 3elzC-4om8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 7 PRO A  60
ILE A 171
LEU A 173
ILE A  57
 None
 0.89A 3p50A-4om8A:
undetectable		 3p50A-4om8A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 7 PRO A  60
ILE A 171
LEU A 173
ILE A  57
 None
 0.89A 3p50B-4om8A:
undetectable		 3p50B-4om8A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 7 PRO A  60
ILE A 171
LEU A 173
ILE A  57
 None
 0.89A 3p50C-4om8A:
undetectable		 3p50C-4om8A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 7 PRO A  60
ILE A 171
LEU A 173
ILE A  57
 None
 0.90A 3p50D-4om8A:
undetectable		 3p50D-4om8A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 7 PRO A  60
ILE A 171
LEU A 173
ILE A  57
 None
 0.89A 3p50E-4om8A:
undetectable		 3p50E-4om8A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		3 / 3 ILE A  84
MET A 133
ARG A 132
 None
 0.87A 4lnwA-4om8A:
undetectable		 4lnwA-4om8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		3 / 3 ILE A  84
MET A 133
ARG A 132
 None
 0.84A 4lnxA-4om8A:
undetectable		 4lnxA-4om8A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		3 / 3 LEU A  10
ILE A  38
ARG A  42
 None
 0.62A 4mk4B-4om8A:
3.7		 4mk4B-4om8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 4 LEU A 104
ILE A 101
GLY A  74
ILE A   8
 None
None
None
NAD  A 402 (-4.6A)
 0.86A 5dzk3-4om8A:
undetectable
5dzkm-4om8A:
undetectable		 5dzk3-4om8A:
1.03
5dzkm-4om8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 5 ILE A 101
GLY A  74
ILE A   8
LEU A 104
 None
None
NAD  A 402 (-4.6A)
None
 0.87A 5dzkB-4om8A:
2.2
5dzkI-4om8A:
undetectable
5dzkW-4om8A:
undetectable		 5dzkB-4om8A:
23.45
5dzkI-4om8A:
20.19
5dzkW-4om8A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 5 ILE A 101
GLY A  74
ILE A   8
LEU A 104
 None
None
NAD  A 402 (-4.6A)
None
 0.83A 5dzkd-4om8A:
undetectable
5dzkk-4om8A:
undetectable
5dzky-4om8A:
undetectable		 5dzkd-4om8A:
23.45
5dzkk-4om8A:
20.19
5dzky-4om8A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 4 ILE A 101
GLY A  74
ILE A   8
LEU A 104
 None
None
NAD  A 402 (-4.6A)
None
 0.81A 5dzkl-4om8A:
undetectable
5dzkz-4om8A:
undetectable		 5dzkl-4om8A:
20.19
5dzkz-4om8A:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4om8 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE
(Mesorhizobium
japonicum) 		4 / 6 ILE A 148
ALA A 112
MET A 133
ASP A 181
 None
 1.06A 6hu9m-4om8A:
undetectable
6hu9q-4om8A:
undetectable		 6hu9m-4om8A:
20.33
6hu9q-4om8A:
19.65