SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4omb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 VAL A 214
SER A 211
ARG A 181
THR A 187
 None
None
PO4  A 401 (-2.8A)
PO4  A 401 (-3.5A)
 1.18A 2f78B-4ombA:
13.7		 2f78B-4ombA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 123
ASP A 253
ASP A 304
 None
 0.70A 2igtA-4ombA:
undetectable		 2igtA-4ombA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 123
ASP A 253
ASP A 304
 None
 0.74A 2igtB-4ombA:
undetectable		 2igtB-4ombA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 306
ILE A 230
GLY A 229
PHE A 128
 None
 0.93A 2vctD-4ombA:
undetectable		 2vctD-4ombA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 271
SER A 294
THR A 296
VAL A 301
ALA A 121
 None
 1.17A 2x2iA-4ombA:
undetectable		 2x2iA-4ombA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 271
SER A 294
THR A 296
VAL A 301
ALA A 121
 None
 1.14A 2x2iC-4ombA:
undetectable		 2x2iC-4ombA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 11 THR A 139
ILE A 146
LEU A 165
ILE A 135
VAL A 218
 None
 1.20A 3a51A-4ombA:
undetectable		 3a51A-4ombA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 THR A 139
ILE A 146
LEU A 165
ILE A 135
VAL A 218
 None
 1.19A 3a51D-4ombA:
undetectable		 3a51D-4ombA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 225
ILE A 230
LEU A 178
PHE A 179
 None
 0.75A 3adxA-4ombA:
undetectable		 3adxA-4ombA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ASN A  53
GLY A  47
THR A  80
ILE A  73
THR A  56
 None
 1.25A 3iv6A-4ombA:
undetectable		 3iv6A-4ombA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 SER A 185
GLY A 186
THR A 187
 PO4  A 401 (-2.5A)
PO4  A 401 (-3.4A)
PO4  A 401 (-3.5A)
 0.12A 3k9wA-4ombA:
undetectable		 3k9wA-4ombA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 THR A  50
LEU A 269
ARG A 267
ASN A 182
 PO4  A 401 (-3.4A)
None
PO4  A 401 ( 4.9A)
None
 1.01A 3kp2A-4ombA:
undetectable
3kp2B-4ombA:
undetectable		 3kp2A-4ombA:
18.93
3kp2B-4ombA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 321
GLY A 322
PHE A 288
TYR A  62
LEU A 293
 None
 1.33A 5czyA-4ombA:
undetectable		 5czyA-4ombA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  76
PRO A  83
GLY A  93
SER A  78
TYR A 272
 None
None
None
PO4  A 401 (-2.5A)
None
 1.35A 5hfjG-4ombA:
undetectable		 5hfjG-4ombA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 223
VAL A 176
GLY A 226
SER A 228
ARG A 181
 None
None
None
None
PO4  A 401 (-2.8A)
 1.32A 5lsaA-4ombA:
undetectable		 5lsaA-4ombA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 133
GLY A 163
ILE A 135
VAL A 176
ILE A 225
 None
 0.97A 6ectA-4ombA:
undetectable		 6ectA-4ombA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		4 / 8 LYS A 100
ARG A  97
VAL A 271
ARG A 181
 None
None
None
PO4  A 401 (-2.8A)
 1.27A 6fbvD-4ombA:
undetectable		 6fbvD-4ombA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4omb PHOSPHATE BINDING
PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 VAL A  46
ALA A  84
GLN A  74
 None
 0.67A 6gb9A-4ombA:
undetectable		 6gb9A-4ombA:
22.83