SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4omg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE
(Streptomyces
melanosporofacie
ns) 		4 / 7 GLN A 125
ALA A  63
PHE A 122
ASN A  59
 None
 1.32A 1t9wA-4omgA:
2.9		 1t9wA-4omgA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE
(Streptomyces
melanosporofacie
ns) 		4 / 6 ARG A  27
PHE A  29
PHE A 253
PHE A 222
 None
 1.40A 3af3A-4omgA:
undetectable		 3af3A-4omgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE
(Streptomyces
melanosporofacie
ns) 		4 / 8 TYR A 194
ALA A 208
THR A 212
LEU A 281
 None
 0.96A 3khmA-4omgA:
undetectable		 3khmA-4omgA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE
(Streptomyces
melanosporofacie
ns) 		4 / 8 SER A 190
LEU A 281
ALA A 209
ALA A 208
 None
 0.82A 3ns1L-4omgA:
undetectable		 3ns1L-4omgA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE
(Streptomyces
melanosporofacie
ns) 		5 / 12 ASP A 258
ASP A 259
PHE A 174
ILE A 218
PHE A 252
 None
 1.33A 4wh5A-4omgA:
undetectable		 4wh5A-4omgA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE
(Streptomyces
melanosporofacie
ns) 		5 / 12 THR A  47
GLU A  50
ALA A  60
PHE A  96
MET A 189
 None
 1.44A 5iwuA-4omgA:
undetectable		 5iwuA-4omgA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE
(Streptomyces
melanosporofacie
ns) 		3 / 3 PHE A 185
ASP A 184
LYS A 188
 None
 0.86A 6awtD-4omgA:
undetectable		 6awtD-4omgA:
19.34