SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4on1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		3 / 3 TRP A 387
ALA A 359
VAL A 388
 None
 0.96A 1bdwA-4on1A:
undetectable
1bdwB-4on1A:
undetectable		 1bdwA-4on1A:
3.28
1bdwB-4on1A:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 5 SER A 383
ASN A 386
ALA A 359
GLU A 360
 None
 1.44A 1lqtA-4on1A:
3.4
1lqtB-4on1A:
3.4		 1lqtA-4on1A:
20.68
1lqtB-4on1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 5 SER A 383
ASN A 386
ALA A 359
GLU A 360
 None
 1.44A 1lquA-4on1A:
3.0
1lquB-4on1A:
3.2		 1lquA-4on1A:
20.68
1lquB-4on1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 9 GLY A 312
GLY A 307
GLY A 271
GLY A 270
ASP A 274
 None
 1.12A 1mxdA-4on1A:
undetectable		 1mxdA-4on1A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 10 THR A 314
THR A 348
HIS A 351
HIS A 355
HIS A 361
 None
None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.2A)
ZN  A 400 (-3.1A)
 0.39A 1r55A-4on1A:
14.6		 1r55A-4on1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 11 HIS A 355
THR A 371
HIS A 351
SER A 383
VAL A 362
 ZN  A 400 (-3.2A)
None
ZN  A 400 (-3.2A)
None
None
 1.25A 1uofA-4on1A:
undetectable		 1uofA-4on1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 8 ASP A 236
TYR A 126
TYR A 138
TYR A 139
 None
 1.47A 2ha2A-4on1A:
undetectable		 2ha2A-4on1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 8 ASP A 236
TYR A 126
TYR A 138
TYR A 139
 None
 1.45A 2ha2B-4on1A:
undetectable		 2ha2B-4on1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 8 THR A 348
HIS A 351
HIS A 355
HIS A 361
 None
ZN  A 400 (-3.2A)
ZN  A 400 (-3.2A)
ZN  A 400 (-3.1A)
 0.11A 2jihB-4on1A:
14.8		 2jihB-4on1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 12 LEU A  48
LEU A  40
ILE A  62
THR A  73
ILE A 104
 None
 1.13A 2jn3A-4on1A:
undetectable		 2jn3A-4on1A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 12 LEU A  48
LEU A  40
ILE A  62
THR A  73
LEU A 105
 None
 1.14A 2jn3A-4on1A:
undetectable		 2jn3A-4on1A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		3 / 3 HIS A 351
HIS A 355
HIS A 361
 ZN  A 400 (-3.2A)
ZN  A 400 (-3.2A)
ZN  A 400 (-3.1A)
 0.28A 2ozrF-4on1A:
8.1		 2ozrF-4on1A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 7 SER A 247
VAL A 259
TYR A 261
ILE A 353
 None
 1.11A 2x45B-4on1A:
undetectable		 2x45B-4on1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 7 SER A 247
VAL A 259
TYR A 261
ILE A 353
 None
 1.09A 2x45C-4on1A:
undetectable		 2x45C-4on1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 8 GLN A 242
ASP A 122
SER A 239
TYR A 109
 None
 1.09A 2xz5A-4on1A:
undetectable
2xz5C-4on1A:
undetectable		 2xz5A-4on1A:
20.26
2xz5C-4on1A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 12 ASN A  57
GLY A  80
ILE A  83
LYS A 260
THR A 258
 None
 1.44A 3a25A-4on1A:
undetectable		 3a25A-4on1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 12 LEU A  92
PHE A 222
LEU A 224
ILE A 237
TYR A 109
 None
 1.13A 3cd2A-4on1A:
undetectable		 3cd2A-4on1A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 7 LEU A 326
LEU A 349
LEU A 357
LEU A  92
 None
 0.84A 3g8iA-4on1A:
undetectable		 3g8iA-4on1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 10 GLY A 354
PHE A 222
LEU A 356
LEU A 357
ILE A 324
 None
 1.31A 3kvrA-4on1A:
undetectable		 3kvrA-4on1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		3 / 3 ARG A 174
ARG A  41
ILE A 121
 None
 0.81A 4b7qC-4on1A:
undetectable		 4b7qC-4on1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		4 / 6 ILE A 177
TYR A 138
TYR A 143
TYR A 139
 None
 0.96A 4g10A-4on1A:
undetectable		 4g10A-4on1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4on1 PUTATIVE
METALLOPROTEASE II
(Bacteroides
fragilis) 		5 / 12 LEU A 304
ILE A 302
ILE A 257
LEU A 248
ILE A 241
 None
 1.23A 5y2tB-4on1A:
undetectable		 5y2tB-4on1A:
undetectable