SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4on3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 4on3 SORTING NEXIN-10
(Homo
sapiens) 		3 / 3 GLN A  21
ILE A  30
TYR A  29
 NO3  A 304 (-2.8A)
None
None
 0.74A 1vifA-4on3A:
undetectable		 1vifA-4on3A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 4on3 SORTING NEXIN-10
(Homo
sapiens) 		5 / 9 GLU A   9
LEU A 121
LEU A 106
ALA A 109
ALA A  42
 None
NA  A 315 (-4.5A)
None
None
None
 1.19A 2bxcB-4on3A:
undetectable		 2bxcB-4on3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4on3 SORTING NEXIN-10
(Homo
sapiens) 		4 / 4 ILE A  30
HIS A  90
MET A  85
ARG A  88
 None
NO3  A 302 (-4.4A)
None
None
 1.45A 4acbB-4on3A:
0.0
4acbC-4on3A:
0.0		 4acbB-4on3A:
17.94
4acbC-4on3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4on3 SORTING NEXIN-10
(Homo
sapiens) 		4 / 5 TYR A  32
GLY A  97
ASP A 100
VAL A  11
 None
 1.14A 4nkvD-4on3A:
undetectable		 4nkvD-4on3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4on3 SORTING NEXIN-10
(Homo
sapiens) 		4 / 6 LEU A  98
LEU A 102
GLU A  99
ILE A  34
 None
None
None
NA  A 315 (-4.7A)
 0.81A 4ww7A-4on3A:
undetectable		 4ww7A-4on3A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4on3 SORTING NEXIN-10
(Homo
sapiens) 		3 / 3 ASN A  67
SER A 116
SER A 115
 None
 0.64A 5gsnA-4on3A:
undetectable		 5gsnA-4on3A:
18.94