SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4on9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 ILE A 475
ILE A 474
GLU A 556
ALA A 558
ASN A 608
 None
 1.20A 1jtxA-4on9A:
undetectable		 1jtxA-4on9A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 VAL A 293
ILE A 370
LEU A 368
ILE A 406
PHE A 310
 None
 1.13A 2gj5A-4on9A:
undetectable		 2gj5A-4on9A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 ILE A 713
ILE A 617
LEU A 711
ASN A 710
ILE A 629
 None
 1.06A 2nnhA-4on9A:
undetectable		 2nnhA-4on9A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 LEU A 430
ILE A 261
LEU A 434
ASP A 435
PHE A 776
 None
 0.88A 3ko0K-4on9A:
undetectable
3ko0L-4on9A:
undetectable
3ko0S-4on9A:
undetectable
3ko0T-4on9A:
undetectable		 3ko0K-4on9A:
10.86
3ko0L-4on9A:
10.86
3ko0S-4on9A:
10.86
3ko0T-4on9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 LEU A 430
ILE A 261
LEU A 434
ASP A 435
PHE A 776
 None
 0.92A 3ko0M-4on9A:
undetectable
3ko0N-4on9A:
undetectable
3ko0O-4on9A:
undetectable
3ko0P-4on9A:
undetectable		 3ko0M-4on9A:
10.86
3ko0N-4on9A:
10.86
3ko0O-4on9A:
10.86
3ko0P-4on9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 PHE A 776
LEU A 434
ASP A 435
LEU A 430
ILE A 261
 None
 0.97A 3ko0M-4on9A:
undetectable
3ko0N-4on9A:
undetectable
3ko0O-4on9A:
undetectable
3ko0P-4on9A:
undetectable		 3ko0M-4on9A:
10.86
3ko0N-4on9A:
10.86
3ko0O-4on9A:
10.86
3ko0P-4on9A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 LEU A 430
ALA A 436
MET A 387
THR A 377
 None
 1.38A 3vasB-4on9A:
undetectable		 3vasB-4on9A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 8 GLN A 306
PHE A 295
ILE A 343
VAL A 293
 None
 0.90A 4dx7B-4on9A:
undetectable		 4dx7B-4on9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		3 / 3 ASP A 550
ARG A 546
ASP A 641
 None
 0.80A 4fp9C-4on9A:
2.8		 4fp9C-4on9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		3 / 3 ASP A 550
ARG A 546
ASP A 641
 None
 0.83A 4fp9F-4on9A:
2.4		 4fp9F-4on9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 8 THR A 377
LEU A 434
VAL A 405
VAL A 294
 None
 1.04A 4l4bA-4on9A:
undetectable		 4l4bA-4on9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 9 ALA A 642
ILE A 660
GLY A 659
ILE A 693
THR A 697
 None
 1.07A 4nptA-4on9A:
undetectable		 4nptA-4on9A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.30A 4olaA-4on9A:
undetectable		 4olaA-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		3 / 3 ASP A 392
LEU A 391
PHE A 388
 None
 0.75A 4pthA-4on9A:
undetectable		 4pthA-4on9A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 6 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.27A 4z4cA-4on9A:
2.1		 4z4cA-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.25A 4z4dA-4on9A:
undetectable		 4z4dA-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.20A 4z4hA-4on9A:
undetectable		 4z4hA-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 7 ILE A 277
LEU A 368
GLY A 257
LYS A 256
 None
 0.78A 4z69A-4on9A:
3.0		 4z69A-4on9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 7 ILE A 406
LEU A 368
GLY A 257
LYS A 256
 None
 0.77A 4z69A-4on9A:
3.0		 4z69A-4on9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 11 LEU A 639
LEU A 614
LEU A 611
ARG A 466
LEU A 632
 None
 1.29A 4zn7B-4on9A:
undetectable		 4zn7B-4on9A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 12 GLY A 415
MET A 761
CYH A 263
THR A 409
LEU A 430
 None
 1.45A 5fhzD-4on9A:
undetectable		 5fhzD-4on9A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.28A 5js1A-4on9A:
2.0		 5js1A-4on9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		5 / 10 HIS A 444
ALA A 254
GLY A 407
ILE A 406
ALA A 251
 None
 1.35A 5vyhA-4on9A:
undetectable		 5vyhA-4on9A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 4on9 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58
(Homo
sapiens) 		4 / 5 LYS A 610
LEU A 741
GLU A 716
TYR A 715
 None
 1.23A 6cbdA-4on9A:
2.2		 6cbdA-4on9A:
20.98